6h5l - Revision history

OCA at 06:50, 17 April 2019

OCA — Wed, 17 Apr 2019 06:50:18 GMT

←Older revision		Revision as of 06:50, 17 April 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h5l OCA], [http://pdbe.org/6h5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h5l RCSB], [http://www.ebi.ac.uk/pdbsum/6h5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h5l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h5l OCA], [http://pdbe.org/6h5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h5l RCSB], [http://www.ebi.ac.uk/pdbsum/6h5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h5l ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The hydroxylamine oxidoreductase/hydrazine dehydrogenase (HAO/HDH) protein family constitutes an important group of octaheme cytochromes c (OCCs). The majority of these proteins form homotrimers, with their subunits being covalently attached to each other via a rare cross-link between the catalytic heme moiety and a conserved tyrosine residue in an adjacent subunit. This covalent cross-link has been proposed to modulate the active-site heme towards oxidative catalysis by distorting the heme plane. In this study, the crystal structure of a stable complex of an HAO homologue (KsHAOr) with its diheme cytochrome c redox partner (KsDH) from the anammox bacterium Kuenenia stuttgartiensis was determined. KsHAOr lacks the tyrosine cross-link and is therefore tuned to reductive catalysis. The molecular model of the KsHAOr-KsDH complex at 2.6 A resolution shows a heterododecameric (alpha6beta6) assembly, which was also shown to be the oligomeric state in solution by analytical ultracentrifugation and multi-angle static light scattering. The 60-heme-containing protein complex reveals a unique extended electron transfer pathway and provides deeper insights into catalysis and electron transfer in reductive OCCs.
		+
		+	A 60-heme reductase complex from an anammox bacterium shows an extended electron transfer pathway.,Dietl A, Maalcke WJ, Ferousi C, Jetten MSM, Kartal B, Barends TRM Acta Crystallogr D Struct Biol. 2019 Mar 1;75(Pt 3):333-341. doi:, 10.1107/S2059798318017473. Epub 2019 Feb 28. PMID:30950404<ref>PMID:30950404</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6h5l" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:19, 10 April 2019

OCA — Wed, 10 Apr 2019 07:19:09 GMT

←Older revision		Revision as of 07:19, 10 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6h5l is ~~ON HOLD until Paper Publication~~	+	==Kuenenia stuttgartiensis reducing HAO-like protein complex Kustc0457/Kustc0458==
-		+	<StructureSection load='6h5l' size='340' side='right'caption='[[6h5l]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~: ~~Dietl~~, A., ~~Maalcke~~, W., ~~Barends~~, T.R.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6h5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Kuenenia_stuttgartiensis Kuenenia stuttgartiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H5L FirstGlance]. <br>
-	~~Description~~: Kuenenia stuttgartiensis ~~reducing HAO-like protein complex Kustc0457/Kustc0458~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxylamine_dehydrogenase Hydroxylamine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.2.6 1.7.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h5l OCA], [http://pdbe.org/6h5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h5l RCSB], [http://www.ebi.ac.uk/pdbsum/6h5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h5l ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hydroxylamine dehydrogenase]]
		+	[[Category: Kuenenia stuttgartiensis]]
		+	[[Category: Large Structures]]
		+	[[Category: Barends, T R.M]]
		+	[[Category: Dietl, A]]
	[[Category: Maalcke, W]]		[[Category: Maalcke, W]]
-	[[Category: ~~Dietl, A~~]]	+	[[Category: Anammox]]
-	[[Category: ~~Barends, T.R.M~~]]	+	[[Category: Oxidoreductase]]
		+	[[Category: Reductase]]

OCA: Protected "6h5l" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2018 17:17:52 GMT

Protected "6h5l" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:17, 1 August 2018

OCA: New page: '''Unreleased structure''' The entry 6h5l is ON HOLD until Paper Publication Authors: Dietl, A., Maalcke, W., Barends, T.R.M. Description: Kuenenia stuttgartiensis reducing HAO-like pr...

OCA — Wed, 01 Aug 2018 17:17:51 GMT

New page: '''Unreleased structure''' The entry 6h5l is ON HOLD until Paper Publication Authors: Dietl, A., Maalcke, W., Barends, T.R.M. Description: Kuenenia stuttgartiensis reducing HAO-like pr...

New page

'''Unreleased structure'''

The entry 6h5l is ON HOLD until Paper Publication

Authors: Dietl, A., Maalcke, W., Barends, T.R.M.

Description: Kuenenia stuttgartiensis reducing HAO-like protein complex Kustc0457/Kustc0458
[[Category: Unreleased Structures]]
[[Category: Maalcke, W]]
[[Category: Dietl, A]]
[[Category: Barends, T.R.M]]