6h60 - Revision history

OCA at 01:14, 11 April 2020

OCA — Sat, 11 Apr 2020 01:14:45 GMT

←Older revision		Revision as of 01:14, 11 April 2020
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	<SX load='6h60' size='340' side='right' viewer='molstar' caption='[[6h60]], [[Resolution\|resolution]] 6.00Å' scene=''>		<SX load='6h60' size='340' side='right' viewer='molstar' caption='[[6h60]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6h60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H60 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6H60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6h60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H60 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6H60 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDHX, PDX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDHX, PDX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6h60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h60 OCA], [http://pdbe.org/6h60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h60 RCSB], [http://www.ebi.ac.uk/pdbsum/6h60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h60 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6h60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h60 OCA], [http://pdbe.org/6h60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h60 RCSB], [http://www.ebi.ac.uk/pdbsum/6h60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h60 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 21:37, 6 March 2020

OCA — Fri, 06 Mar 2020 21:37:10 GMT

←Older revision		Revision as of 21:37, 6 March 2020
Line 1:		Line 1:

	==pseudo-atomic structural model of the E3BP component of the human pyruvate dehydrogenase multienzyme complex==		==pseudo-atomic structural model of the E3BP component of the human pyruvate dehydrogenase multienzyme complex==
-	<~~StructureSection~~ load='6h60' size='340' side='right'caption='[[6h60]], [[Resolution\|resolution]] 6.00Å' scene=''>	+	<SX load='6h60' size='340' side='right' viewer='molstar' caption='[[6h60]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6h60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H60 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6h60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H60 FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 18:25, 11 December 2019

OCA — Wed, 11 Dec 2019 18:25:09 GMT

←Older revision		Revision as of 18:25, 11 December 2019
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	</div>		</div>
	<div class="pdbe-citations 6h60" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6h60" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pyruvate dehydrogenase 3D structures\|Pyruvate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:22, 10 July 2019

OCA — Wed, 10 Jul 2019 06:22:04 GMT

←Older revision		Revision as of 06:22, 10 July 2019
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	<StructureSection load='6h60' size='340' side='right'caption='[[6h60]], [[Resolution\|resolution]] 6.00Å' scene=''>		<StructureSection load='6h60' size='340' side='right'caption='[[6h60]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6h60]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6h60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H60 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h60 OCA], [http://pdbe.org/6h60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h60 RCSB], [http://www.ebi.ac.uk/pdbsum/6h60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h60 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDHX, PDX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h60 OCA], [http://pdbe.org/6h60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h60 RCSB], [http://www.ebi.ac.uk/pdbsum/6h60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h60 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Haselbach, D]]		[[Category: Haselbach, D]]
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	[[Category: Stark, H]]		[[Category: Stark, H]]
	[[Category: Tittmann, K]]		[[Category: Tittmann, K]]
-	[[Category: Human]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Pyruvate dehydrogenase]]		[[Category: Pyruvate dehydrogenase]]

OCA at 22:44, 5 June 2019

OCA — Wed, 05 Jun 2019 22:44:50 GMT

←Older revision		Revision as of 22:44, 5 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6h60 is ~~ON HOLD~~	+	==pseudo-atomic structural model of the E3BP component of the human pyruvate dehydrogenase multienzyme complex==
		+	<StructureSection load='6h60' size='340' side='right'caption='[[6h60]], [[Resolution\|resolution]] 6.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6h60]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H60 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h60 OCA], [http://pdbe.org/6h60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h60 RCSB], [http://www.ebi.ac.uk/pdbsum/6h60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h60 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ODPX_HUMAN ODPX_HUMAN]] Defects in PDHX are the cause of pyruvate dehydrogenase E3-binding protein deficiency (PDHXD) [MIM:[http://omim.org/entry/245349 245349]].<ref>PMID:9399911</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ODPX_HUMAN ODPX_HUMAN]] Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The pseudo-atomic structural model of human pyruvate dehydrogenase complex (PDHc) core composed of full-length E2 and E3BP components, calculated from our cryoelectron microscopy-derived density maps at 6-A resolution, is similar to those of prokaryotic E2 structures. The spatial organization of human PDHc components as evidenced by negative-staining electron microscopy and native mass spectrometry is not homogeneous, and entails the unanticipated formation of local clusters of E1:E2 and E3BP:E3 complexes. Such uneven, clustered organization translates into specific duties for E1-E2 clusters (oxidative decarboxylation and acetyl transfer) and E3BP-E3 clusters (regeneration of reduced lipoamide) corresponding to half-reactions of the PDHc catalytic cycle. The addition of substrate coenzyme A modulates the conformational landscape of PDHc, in particular of the lipoyl domains, extending the postulated multiple random coupling mechanism. The conformational and associated chemical landscapes of PDHc are thus not determined entirely stochastically, but are restrained and channeled through an asymmetric architecture and further modulated by substrate binding.

-	~~Authors~~:	+	Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.,Prajapati S, Haselbach D, Wittig S, Patel MS, Chari A, Schmidt C, Stark H, Tittmann K Structure. 2019 Apr 26. pii: S0969-2126(19)30131-5. doi:, 10.1016/j.str.2019.04.009. PMID:31130485<ref>PMID:31130485</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6h60" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Haselbach, D]]
		+	[[Category: Prajapati, S]]
		+	[[Category: Stark, H]]
		+	[[Category: Tittmann, K]]
		+	[[Category: Human]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pyruvate dehydrogenase]]

OCA: Protected "6h60" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2018 17:19:14 GMT

Protected "6h60" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:19, 1 August 2018

OCA: New page: '''Unreleased structure''' The entry 6h60 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Aug 2018 17:19:12 GMT

New page: '''Unreleased structure''' The entry 6h60 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6h60 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]