6h6p - Revision history

OCA at 09:13, 1 May 2019

OCA — Wed, 01 May 2019 09:13:28 GMT

←Older revision		Revision as of 09:13, 1 May 2019
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	==UbiJ-SCP2 Ubiquinone synthesis protein==		==UbiJ-SCP2 Ubiquinone synthesis protein==
-	<StructureSection load='6h6p' size='340' side='right' caption='[[6h6p]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='6h6p' size='340' side='right'caption='[[6h6p]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6h6p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6h6p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H6P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ubiJ, yigP, b3834, JW3811 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h6p OCA], [http://pdbe.org/6h6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h6p RCSB], [http://www.ebi.ac.uk/pdbsum/6h6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h6p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h6p OCA], [http://pdbe.org/6h6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h6p RCSB], [http://www.ebi.ac.uk/pdbsum/6h6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h6p ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Ciccone, L]]		[[Category: Ciccone, L]]
	[[Category: Fontecave, M]]		[[Category: Fontecave, M]]

OCA at 09:30, 13 February 2019

OCA — Wed, 13 Feb 2019 09:30:14 GMT

←Older revision		Revision as of 09:30, 13 February 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6h6p is ~~ON HOLD~~	+	==UbiJ-SCP2 Ubiquinone synthesis protein==
		+	<StructureSection load='6h6p' size='340' side='right' caption='[[6h6p]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6h6p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H6P FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h6p OCA], [http://pdbe.org/6h6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h6p RCSB], [http://www.ebi.ac.uk/pdbsum/6h6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h6p ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UBIJ_ECOLI UBIJ_ECOLI]] Required for ubiquinone (coenzyme Q) biosynthesis under aerobic conditions.<ref>PMID:24142253</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ubiquinone (UQ) is a polyprenylated lipid that is conserved from bacteria to humans and is crucial to cellular respiration. How the cell orchestrates the efficient synthesis of UQ, which involves the modification of extremely hydrophobic substrates by multiple sequential enzymes, remains an unresolved issue. Here, we demonstrate that seven Ubi proteins form the Ubi complex, a stable metabolon that catalyzes the last six reactions of the UQ biosynthetic pathway in Escherichia coli. The SCP2 domain of UbiJ forms an extended hydrophobic cavity that binds UQ intermediates inside the 1-MDa Ubi complex. We purify the Ubi complex from cytoplasmic extracts and demonstrate that UQ biosynthesis occurs in this fraction, challenging the current thinking of a membrane-associated biosynthetic process. Collectively, our results document a rare case of stable metabolon and highlight how the supramolecular organization of soluble enzymes allows the modification of hydrophobic substrates in a hydrophilic environment.

-	~~Authors~~:	+	A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone.,Hajj Chehade M, Pelosi L, Fyfe CD, Loiseau L, Rascalou B, Brugiere S, Kazemzadeh K, Vo CD, Ciccone L, Aussel L, Coute Y, Fontecave M, Barras F, Lombard M, Pierrel F Cell Chem Biol. 2018 Dec 17. pii: S2451-9456(18)30439-2. doi:, 10.1016/j.chembiol.2018.12.001. PMID:30686758<ref>PMID:30686758</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6h6p" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ciccone, L]]
		+	[[Category: Fontecave, M]]
		+	[[Category: Fyfe, C D]]
		+	[[Category: Legrand, P]]
		+	[[Category: Lombard, M]]
		+	[[Category: Pecqueur, L]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Scp2 lipid binding protein ubiquinone synthesis protein]]

OCA: Protected "6h6p" [edit=sysop:move=sysop]

OCA — Thu, 09 Aug 2018 20:04:48 GMT

Protected "6h6p" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:04, 9 August 2018

OCA: New page: '''Unreleased structure''' The entry 6h6p is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 09 Aug 2018 20:04:47 GMT

New page: '''Unreleased structure''' The entry 6h6p is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6h6p is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]