OCA at 12:35, 16 January 2019

OCA — Wed, 16 Jan 2019 12:35:18 GMT

←Older revision		Revision as of 12:35, 16 January 2019
Line 3:		Line 3:
	<StructureSection load='6h7u' size='340' side='right' caption='[[6h7u]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6h7u' size='340' side='right' caption='[[6h7u]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6h7u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H7U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6h7u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27844 Atcc 27844]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H7U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FVT:5-azanyl-4-oxidanylidene-pentanoic+acid'>FVT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FVT:5-azanyl-4-oxidanylidene-pentanoic+acid'>FVT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6gz9\|6gz9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6gz9\|6gz9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BL313_09825 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1290 ATCC 27844])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h7u OCA], [http://pdbe.org/6h7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h7u RCSB], [http://www.ebi.ac.uk/pdbsum/6h7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h7u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h7u OCA], [http://pdbe.org/6h7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h7u RCSB], [http://www.ebi.ac.uk/pdbsum/6h7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h7u ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A major challenge in drug development is the optimization of intestinal absorption and cellular uptake. A successful strategy has been to develop prodrug molecules, which hijack solute carrier (SLC) transporters for active transport into the body. The proton-coupled oligopeptide transporters, PepT1 and PepT2, have been successfully targeted using this approach. Peptide transporters display a remarkable capacity to recognize a diverse library of di- and tripeptides, making them extremely promiscuous and major contributors to the pharmacokinetic profile of several important drug classes, including beta-lactam antibiotics and antiviral and antineoplastic agents. Of particular interest has been their ability to recognize amino acid and peptide-based prodrug molecules, thereby providing a rational approach to improving drug transport into the body. However, the structural basis for prodrug recognition has remained elusive. Here we present crystal structures of a prokaryotic homolog of the mammalian transporters in complex with the antiviral prodrug valacyclovir and the peptide-based photodynamic therapy agent, 5-aminolevulinic acid. The valacyclovir structure reveals that prodrug recognition is mediated through both the amino acid scaffold and the ester bond, which is commonly used to link drug molecules to the carrier's physiological ligand, whereas 5-aminolevulinic acid makes far fewer interactions compared with physiological peptides. These structures provide a unique insight into how peptide transporters interact with xenobiotic molecules and provide a template for further prodrug development.
		+
		+	Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters.,Minhas GS, Newstead S Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):804-809. doi:, 10.1073/pnas.1813715116. Epub 2019 Jan 2. PMID:30602453<ref>PMID:30602453</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6h7u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 27844]]
	[[Category: Minhas, G S]]		[[Category: Minhas, G S]]
	[[Category: Newstead, S]]		[[Category: Newstead, S]]

OCA at 08:20, 26 December 2018

OCA — Wed, 26 Dec 2018 08:20:43 GMT

←Older revision		Revision as of 08:20, 26 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6h7u is ~~ON HOLD~~	+	==Crystal structure of a POT family transporter in complex with 5-aminolevulinic acid==
-		+	<StructureSection load='6h7u' size='340' side='right' caption='[[6h7u]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6h7u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H7U FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FVT:5-azanyl-4-oxidanylidene-pentanoic+acid'>FVT</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6gz9\|6gz9]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h7u OCA], [http://pdbe.org/6h7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h7u RCSB], [http://www.ebi.ac.uk/pdbsum/6h7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h7u ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Minhas, G S]]
		+	[[Category: Newstead, S]]
		+	[[Category: Major facilitator superfamily]]
		+	[[Category: Membrane protein]]
		+	[[Category: Peptide complex]]
		+	[[Category: Pot family transporter]]

OCA: Protected "6h7u" [edit=sysop:move=sysop]

OCA — Thu, 09 Aug 2018 20:08:37 GMT

Protected "6h7u" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:08, 9 August 2018

OCA: New page: '''Unreleased structure''' The entry 6h7u is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 09 Aug 2018 20:08:35 GMT

New page: '''Unreleased structure''' The entry 6h7u is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6h7u is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6h7u - Revision history

OCA at 12:35, 16 January 2019

OCA at 08:20, 26 December 2018

OCA: Protected "6h7u" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6h7u is ON HOLD Authors: Description: Category: Unreleased Structures