OCA at 05:33, 12 June 2019

OCA — Wed, 12 Jun 2019 05:33:13 GMT

←Older revision		Revision as of 05:33, 12 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6h9a is ~~ON HOLD~~	+	==Crystal structure of anaerobic ergothioneine biosynthesis enzyme from Chlorobium limicola in complex with natural substrate trimethyl histidine.==
		+	<StructureSection load='6h9a' size='340' side='right'caption='[[6h9a]], [[Resolution\|resolution]] 2.83Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6h9a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H9A FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVJ:N,N,N-TRIMETHYL-HISTIDINE'>AVJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h9a OCA], [http://pdbe.org/6h9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h9a RCSB], [http://www.ebi.ac.uk/pdbsum/6h9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h9a ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ergothioneine is an emergent factor in cellular redox biochemistry in humans and pathogenic bacteria. Broad consensus has formed around the idea that ergothioneine protects cells against reactive oxygen species. The recent discovery that anaerobic microorganisms make the same metabolite using oxygen-independent chemistry indicates that ergothioneine also plays physiological roles under anoxic conditions. In this report, we describe the crystal structure of the anaerobic ergothioneine biosynthetic enzyme EanB from green sulfur bacterium Chlorobium limicola. This enzyme catalyzes the oxidative sulfurization of N-alpha-trimethyl histidine. On the basis of structural and kinetic evidence, we describe the catalytic mechanism of this unusual C-S bond-forming reaction. Significant active-site conservation among distant EanB homologues suggests that the oxidative sulfurization of heterocyclic substrates may occur in a broad range of bacteria.

-	~~Authors~~:	+	Structural and Mechanistic Basis for Anaerobic Ergothioneine Biosynthesis.,Leisinger F, Burn R, Meury M, Lukat P, Seebeck FP J Am Chem Soc. 2019 May 1;141(17):6906-6914. doi: 10.1021/jacs.8b12596. Epub 2019, Apr 23. PMID:30943021<ref>PMID:30943021</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6h9a" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Burn, R]]
		+	[[Category: Leisinger, F]]
		+	[[Category: Lukat, P]]
		+	[[Category: Meury, M]]
		+	[[Category: Seebeck, F P]]
		+	[[Category: Metabolic role: anaerobic ergothioneine biosynthesis chemical activity: sulfur transfer]]
		+	[[Category: Transferase]]

OCA: Protected "6h9a" [edit=sysop:move=sysop]

OCA — Thu, 09 Aug 2018 20:12:05 GMT

Protected "6h9a" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:12, 9 August 2018

OCA: New page: '''Unreleased structure''' The entry 6h9a is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 09 Aug 2018 20:12:04 GMT

New page: '''Unreleased structure''' The entry 6h9a is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6h9a is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6h9a - Revision history

OCA at 05:33, 12 June 2019

OCA: Protected "6h9a" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6h9a is ON HOLD Authors: Description: Category: Unreleased Structures