OCA at 06:56, 3 April 2019

OCA — Wed, 03 Apr 2019 06:56:51 GMT

←Older revision		Revision as of 06:56, 3 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6h9v is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of deaminated P domain from norovirus strain Saga GII-4 in complex with Fuc==
		+	<StructureSection load='6h9v' size='340' side='right'caption='[[6h9v]], [[Resolution\|resolution]] 1.52Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6h9v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H9V FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFU:ALPHA-L-METHYL-FUCOSE'>MFU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IAS:BETA-L-ASPARTIC+ACID'>IAS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oo6\|4oo6]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h9v OCA], [http://pdbe.org/6h9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h9v RCSB], [http://www.ebi.ac.uk/pdbsum/6h9v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h9v ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for infection, but how this binding event promotes the infection of host cells is unknown. Here, we employ protein NMR experiments supported by mass spectrometry and crystallography to study HBGA binding to the P-domain of a prevalent virus strain (GII.4). We report a highly selective transformation of asparagine 373, located in an antigenic loop adjoining the HBGA binding site, into an iso-aspartate residue. This spontaneous post-translational modification (PTM) proceeds with an estimated half-life of a few days at physiological temperatures, independent of the presence of HBGAs but dramatically affecting HBGA recognition. Sequence conservation and the surface-exposed position of this PTM suggest an important role in infection and immune recognition for many norovirus strains.

-	~~Authors~~:	+	A post-translational modification of human Norovirus capsid protein attenuates glycan binding.,Mallagaray A, Creutznacher R, Dulfer J, Mayer PHO, Grimm LL, Orduna JM, Trabjerg E, Stehle T, Rand KD, Blaum BS, Uetrecht C, Peters T Nat Commun. 2019 Mar 21;10(1):1320. doi: 10.1038/s41467-019-09251-5. PMID:30899001<ref>PMID:30899001</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6h9v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Blaum, B S]]
		+	[[Category: Meyer, P H.O]]
		+	[[Category: Fucose]]
		+	[[Category: Glycan]]
		+	[[Category: Isoaspartate]]
		+	[[Category: Isopeptide]]
		+	[[Category: Protruding domain]]
		+	[[Category: Receptor]]
		+	[[Category: Viral capsid protein]]
		+	[[Category: Viral protein]]

OCA at 06:01, 12 September 2018

OCA — Wed, 12 Sep 2018 06:01:02 GMT

←Older revision		Revision as of 06:01, 12 September 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6h9v is ON HOLD	+	The entry 6h9v is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6h9v" [edit=sysop:move=sysop]

OCA — Wed, 15 Aug 2018 15:00:47 GMT

Protected "6h9v" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:00, 15 August 2018

OCA: New page: '''Unreleased structure''' The entry 6h9v is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Aug 2018 15:00:45 GMT

New page: '''Unreleased structure''' The entry 6h9v is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6h9v is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6h9v - Revision history

OCA at 06:56, 3 April 2019

OCA at 06:01, 12 September 2018

OCA: Protected "6h9v" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6h9v is ON HOLD Authors: Description: Category: Unreleased Structures