6hag - Revision history

OCA at 16:07, 29 January 2020

OCA — Wed, 29 Jan 2020 16:07:08 GMT

←Older revision		Revision as of 16:07, 29 January 2020
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	</div>		</div>
	<div class="pdbe-citations 6hag" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6hag" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Riboswitch 3D structures\|Riboswitch 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:23, 20 March 2019

OCA — Wed, 20 Mar 2019 08:23:41 GMT

←Older revision		Revision as of 08:23, 20 March 2019
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	==The structure of the SAM/SAH-binding riboswitch.==		==The structure of the SAM/SAH-binding riboswitch.==
-	<StructureSection load='6hag' size='340' side='right' caption='[[6hag]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='6hag' size='340' side='right'caption='[[6hag]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6hag]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HAG FirstGlance]. <br>		<table><tr><td colspan='2'>[[6hag]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HAG FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Weickhmann, A K]]		[[Category: Weickhmann, A K]]
	[[Category: Pseudoknot]]		[[Category: Pseudoknot]]

OCA at 06:36, 9 January 2019

OCA — Wed, 09 Jan 2019 06:36:36 GMT

←Older revision		Revision as of 06:36, 9 January 2019
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-	'''Unreleased structure'''

-	The ~~entry~~ 6hag is ~~ON HOLD until Paper~~ Publication	+	==The structure of the SAM/SAH-binding riboswitch.==
		+	<StructureSection load='6hag' size='340' side='right' caption='[[6hag]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hag]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HAG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hag OCA], [http://pdbe.org/6hag PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hag RCSB], [http://www.ebi.ac.uk/pdbsum/6hag PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hag ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S-adenosylmethionine (SAM) is a central metabolite since it is used as a methyl group donor in many different biochemical reactions. Many bacteria control intracellular SAM concentrations using riboswitch-based mechanisms. A number of structurally different riboswitch families specifically bind to SAM and mainly regulate the transcription or the translation of SAM-biosynthetic enzymes. In addition, a highly specific riboswitch class recognizes S-adenosylhomocysteine (SAH)-the product of SAM-dependent methyl group transfer reactions-and regulates enzymes responsible for SAH hydrolysis. High-resolution structures are available for many of these riboswitch classes and illustrate how they discriminate between the two structurally similar ligands SAM and SAH. The so-called SAM/SAH riboswitch class binds both ligands with similar affinities and is structurally not yet characterized. Here, we present a high-resolution nuclear magnetic resonance structure of a member of the SAM/SAH-riboswitch class in complex with SAH. Ligand binding induces pseudoknot formation and sequestration of the ribosome binding site. Thus, the SAM/SAH-riboswitches are translational 'OFF'-switches. Our results establish a structural basis for the unusual bispecificity of this riboswitch class. In conjunction with genomic data our structure suggests that the SAM/SAH-riboswitches might be an evolutionary late invention and not a remnant of a primordial RNA-world as suggested for other riboswitches.

-	~~Authors:~~ Weickhmann, A.K.	+	The structure of the SAM/SAH-binding riboswitch.,Weickhmann AK, Keller H, Wurm JP, Strebitzer E, Juen MA, Kremser J, Weinberg Z, Kreutz C, Duchardt-Ferner E, Wohnert J Nucleic Acids Res. 2018 Dec 27. pii: 5264287. doi: 10.1093/nar/gky1283. PMID:30590743<ref>PMID:30590743</ref>

-	~~Description: The structure~~ of the ~~SAM~~/~~SAH~~-~~binding riboswitch.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Weickhmann, A.K~~]]	+	<div class="pdbe-citations 6hag" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Weickhmann, A K]]
		+	[[Category: Pseudoknot]]
		+	[[Category: Riboswitch]]
		+	[[Category: Rna]]
		+	[[Category: Sah]]
		+	[[Category: Sam]]

OCA: Protected "6hag" [edit=sysop:move=sysop]

OCA — Wed, 15 Aug 2018 15:02:51 GMT

Protected "6hag" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:02, 15 August 2018

OCA: New page: '''Unreleased structure''' The entry 6hag is ON HOLD until Paper Publication Authors: Weickhmann, A.K. Description: The structure of the SAM/SAH-binding riboswitch. [[Category: Unrelea...

OCA — Wed, 15 Aug 2018 15:02:49 GMT

New page: '''Unreleased structure''' The entry 6hag is ON HOLD until Paper Publication Authors: Weickhmann, A.K. Description: The structure of the SAM/SAH-binding riboswitch. [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 6hag is ON HOLD until Paper Publication

Authors: Weickhmann, A.K.

Description: The structure of the SAM/SAH-binding riboswitch.
[[Category: Unreleased Structures]]
[[Category: Weickhmann, A.K]]