6hc0 - Revision history

OCA at 07:52, 6 November 2019

OCA — Wed, 06 Nov 2019 07:52:52 GMT

←Older revision		Revision as of 07:52, 6 November 2019
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	<StructureSection load='6hc0' size='340' side='right'caption='[[6hc0]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='6hc0' size='340' side='right'caption='[[6hc0]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hc0]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HC0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hc0]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdeba Bdeba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hbz\|6hbz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hbz\|6hbz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bd0742 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264462 BDEBA])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hc0 OCA], [http://pdbe.org/6hc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6hc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hc0 OCA], [http://pdbe.org/6hc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6hc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hc0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial second messenger cyclic-di-GMP is a widespread, prominent effector of lifestyle change. An example of this occurs in the predatory bacterium Bdellovibrio bacteriovorus, which cycles between free-living and intraperiplasmic phases after entering (and killing) another bacterium. The initiation of prey invasion is governed by DgcB (GGDEF enzyme) that produces cyclic-di-GMP in response to an unknown stimulus. Here, we report the structure of DgcB, and demonstrate that the GGDEF and sensory forkhead-associated (FHA) domains form an asymmetric dimer. Our structures indicate that the FHA domain is a consensus phosphopeptide sensor, and that the ligand for activation is surprisingly derived from the N-terminal region of DgcB itself. We confirm this hypothesis by determining the structure of a FHA:phosphopeptide complex, from which we design a constitutively-active mutant (confirmed via enzyme assays). Our results provide an understanding of the stimulus driving DgcB-mediated prey invasion and detail a unique mechanism of GGDEF enzyme regulation.
		+
		+	Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio.,Meek RW, Cadby IT, Moynihan PJ, Lovering AL Nat Commun. 2019 Sep 9;10(1):4086. doi: 10.1038/s41467-019-12051-6. PMID:31501441<ref>PMID:31501441</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6hc0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bdeba]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lovering, A L]]		[[Category: Lovering, A L]]

OCA at 15:21, 28 August 2019

OCA — Wed, 28 Aug 2019 15:21:45 GMT

←Older revision		Revision as of 15:21, 28 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6hc0 is ~~ON HOLD~~	+	==Bdellovibrio bacteriovorus DgcB FHA domain, tail complex==
-		+	<StructureSection load='6hc0' size='340' side='right'caption='[[6hc0]], [[Resolution\|resolution]] 1.87Å' scene=''>
-	~~Authors~~: ~~Lovering~~, A.L., ~~Meek~~, R.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6hc0]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HC0 FirstGlance]. <br>
-	~~Description~~: ~~Bdellovibrio bacteriovorus DgcB FHA domain~~, ~~tail complex~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hbz\|6hbz]]</td></tr>
-	[[Category: Lovering, A.L]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hc0 OCA], [http://pdbe.org/6hc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6hc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hc0 ProSAT]</span></td></tr>
-	[[Category: Meek, R.W]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lovering, A L]]
		+	[[Category: Meek, R W]]
		+	[[Category: C-di-gmp]]
		+	[[Category: Diguanylate cyclase]]
		+	[[Category: Fha]]
		+	[[Category: Ggdef]]
		+	[[Category: Signaling protein]]

OCA: Protected "6hc0" [edit=sysop:move=sysop]

OCA — Wed, 22 Aug 2018 04:55:37 GMT

Protected "6hc0" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 22 August 2018

OCA: New page: '''Unreleased structure''' The entry 6hc0 is ON HOLD Authors: Lovering, A.L., Meek, R.W. Description: Bdellovibrio bacteriovorus DgcB FHA domain, tail complex [[Category: Unreleased St...

OCA — Wed, 22 Aug 2018 04:55:36 GMT

New page: '''Unreleased structure''' The entry 6hc0 is ON HOLD Authors: Lovering, A.L., Meek, R.W. Description: Bdellovibrio bacteriovorus DgcB FHA domain, tail complex [[Category: Unreleased St...

New page

'''Unreleased structure'''

The entry 6hc0 is ON HOLD

Authors: Lovering, A.L., Meek, R.W.

Description: Bdellovibrio bacteriovorus DgcB FHA domain, tail complex
[[Category: Unreleased Structures]]
[[Category: Lovering, A.L]]
[[Category: Meek, R.W]]