6hcj - Revision history

OCA at 01:19, 11 April 2020

OCA — Sat, 11 Apr 2020 01:19:22 GMT

←Older revision		Revision as of 01:19, 11 April 2020
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	<SX load='6hcj' size='340' side='right' viewer='molstar' caption='[[6hcj]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6hcj' size='340' side='right' viewer='molstar' caption='[[6hcj]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hcj]] is a 85 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6HCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hcj]] is a 85 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6HCJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcj OCA], [http://pdbe.org/6hcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcj RCSB], [http://www.ebi.ac.uk/pdbsum/6hcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6hcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcj OCA], [http://pdbe.org/6hcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcj RCSB], [http://www.ebi.ac.uk/pdbsum/6hcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:40, 6 March 2020

OCA — Fri, 06 Mar 2020 21:40:01 GMT

←Older revision		Revision as of 21:40, 6 March 2020
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs==		==Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs==
-	<~~StructureSection~~ load='6hcj' size='340' side='right' caption='[[6hcj]], [[Resolution\|resolution]] 3.80Å' scene=''>	+	<SX load='6hcj' size='340' side='right' viewer='molstar' caption='[[6hcj]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6hcj]] is a 85 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6hcj]] is a 85 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCJ FirstGlance]. <br>
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcj OCA], [http://pdbe.org/6hcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcj RCSB], [http://www.ebi.ac.uk/pdbsum/6hcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcj OCA], [http://pdbe.org/6hcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcj RCSB], [http://www.ebi.ac.uk/pdbsum/6hcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcj ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]		[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
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	</div>		</div>
	<div class="pdbe-citations 6hcj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6hcj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Chandrasekaran, V]]		[[Category: Chandrasekaran, V]]

OCA at 08:12, 17 October 2018

OCA — Wed, 17 Oct 2018 08:12:09 GMT

←Older revision		Revision as of 08:12, 17 October 2018
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	{{Large structure}}
		+	==Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs==
		+	<StructureSection load='6hcj' size='340' side='right' caption='[[6hcj]], [[Resolution\|resolution]] 3.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hcj]] is a 85 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcj OCA], [http://pdbe.org/6hcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcj RCSB], [http://www.ebi.ac.uk/pdbsum/6hcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcj ProSAT]</span></td></tr>
		+	</table>
		+	{{Large structure}}
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and ubiquitinates stalled ribosomes selectively is unclear. Here, we find that the minimal unit engaged by ZNF598 is the collided di-ribosome, a molecular species that arises when a trailing ribosome encounters a slower leading ribosome. The collided di-ribosome structure reveals an extensive 40S-40S interface in which the ubiquitination targets of ZNF598 reside. The paucity of 60S interactions allows for different ribosome rotation states, explaining why ZNF598 recognition is indifferent to how the leading ribosome has stalled. The use of ribosome collisions as a proxy for stalling allows the degree of tolerable slowdown to be tuned by the initiation rate on that mRNA; hence, the threshold for triggering quality control is substrate specific. These findings illustrate how higher-order ribosome architecture can be exploited by cellular factors to monitor translation status.

-	~~The entry 6hcj is ON HOLD~~	+	ZNF598 Is a Quality Control Sensor of Collided Ribosomes.,Juszkiewicz S, Chandrasekaran V, Lin Z, Kraatz S, Ramakrishnan V, Hegde RS Mol Cell. 2018 Oct 1. pii: S1097-2765(18)30697-X. doi:, 10.1016/j.molcel.2018.08.037. PMID:30293783<ref>PMID:30293783</ref>

-	~~Authors: Juszkiewicz~~, S.~~, Chandrasekaran, V., Lin, Z., Kraatz,~~ S.~~, Ramakrishnan, V., Hegde, R.S~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A~~/~~P and P~~/~~E tRNAs~~	+	<div class="pdbe-citations 6hcj" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Chandrasekaran, V]]
		+	[[Category: Hegde, R S]]
	[[Category: Juszkiewicz, S]]		[[Category: Juszkiewicz, S]]
		+	[[Category: Kraatz, S]]
	[[Category: Lin, Z]]		[[Category: Lin, Z]]
-	[[Category: Chandrasekaran, V]]
-	[[Category: Hegde, R.S]]
-	[[Category: Kraatz, S]]
	[[Category: Ramakrishnan, V]]		[[Category: Ramakrishnan, V]]
		+	[[Category: Quality control]]
		+	[[Category: Ribosome]]
		+	[[Category: Translation]]

OCA: Protected "6hcj" [edit=sysop:move=sysop]

OCA — Wed, 22 Aug 2018 04:57:09 GMT

Protected "6hcj" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 22 August 2018

OCA: New page: '''Unreleased structure''' The entry 6hcj is ON HOLD Authors: Juszkiewicz, S., Chandrasekaran, V., Lin, Z., Kraatz, S., Ramakrishnan, V., Hegde, R.S. Description: Structure of the rabb...

OCA — Wed, 22 Aug 2018 04:57:07 GMT

New page: '''Unreleased structure''' The entry 6hcj is ON HOLD Authors: Juszkiewicz, S., Chandrasekaran, V., Lin, Z., Kraatz, S., Ramakrishnan, V., Hegde, R.S. Description: Structure of the rabb...

New page

'''Unreleased structure'''

The entry 6hcj is ON HOLD

Authors: Juszkiewicz, S., Chandrasekaran, V., Lin, Z., Kraatz, S., Ramakrishnan, V., Hegde, R.S.

Description: Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs
[[Category: Unreleased Structures]]
[[Category: Juszkiewicz, S]]
[[Category: Lin, Z]]
[[Category: Chandrasekaran, V]]
[[Category: Hegde, R.S]]
[[Category: Kraatz, S]]
[[Category: Ramakrishnan, V]]