6hcx - Revision history

OCA at 10:36, 5 September 2018

OCA — Wed, 05 Sep 2018 10:36:05 GMT

←Older revision		Revision as of 10:36, 5 September 2018
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	<StructureSection load='6hcx' size='340' side='right' caption='[[6hcx]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='6hcx' size='340' side='right' caption='[[6hcx]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hcx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hcx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a5 I75a5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=384509 I75A5])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcx OCA], [http://pdbe.org/6hcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcx RCSB], [http://www.ebi.ac.uk/pdbsum/6hcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcx OCA], [http://pdbe.org/6hcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcx RCSB], [http://www.ebi.ac.uk/pdbsum/6hcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcx ProSAT]</span></td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: I75a5]]
	[[Category: Garman, E F]]		[[Category: Garman, E F]]
	[[Category: Hobbs, J R]]		[[Category: Hobbs, J R]]
	[[Category: Kuhn, P]]		[[Category: Kuhn, P]]
	[[Category: Laver, W G]]		[[Category: Laver, W G]]
-	[[Category: Murray, J M]]	+	[[Category: Murray, J W]]
	[[Category: Salinger, M T]]		[[Category: Salinger, M T]]
	[[Category: Complex]]		[[Category: Complex]]

OCA at 07:37, 29 August 2018

OCA — Wed, 29 Aug 2018 07:37:07 GMT

←Older revision		Revision as of 07:37, 29 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6hcx ~~is ON HOLD~~	+	==Influenza Virus N9 Neuraminidase A complex with Zanamivir molecule (Tern).==
-		+	<StructureSection load='6hcx' size='340' side='right' caption='[[6hcx]], [[Resolution\|resolution]] 1.30Å' scene=''>
-	~~Authors~~: ~~Salinger, M~~.T., ~~Hobbs~~, J.R., ~~Murray~~, J.M., ~~Laver~~, W.G.~~, Kuhn, P~~., ~~Garman~~, E.F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6hcx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCX FirstGlance]. <br>
-	~~Description~~: ~~Influenza Virus N9 Neuraminidase A complex~~ with ~~Zanamivir molecule (Tern)~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	[[Category: Garman, E.F]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcx OCA], [http://pdbe.org/6hcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcx RCSB], [http://www.ebi.ac.uk/pdbsum/6hcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcx ProSAT]</span></td></tr>
-	[[Category: Hobbs, J.R]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Exo-alpha-sialidase]]
		+	[[Category: Garman, E F]]
		+	[[Category: Hobbs, J R]]
	[[Category: Kuhn, P]]		[[Category: Kuhn, P]]
-	[[Category: Laver, W.G]]	+	[[Category: Laver, W G]]
-	[[Category: ~~Salinger~~, M.T]]	+	[[Category: Murray, J M]]
-	[[Category: ~~Murray~~, J.M]]	+	[[Category: Salinger, M T]]
		+	[[Category: Complex]]
		+	[[Category: Enzyme]]
		+	[[Category: Hydrolase]]
		+	[[Category: Influenza]]
		+	[[Category: Inhibitor]]
		+	[[Category: N9]]
		+	[[Category: Neuraminidase]]
		+	[[Category: Relenza]]
		+	[[Category: Virus]]
		+	[[Category: Zanamivir]]

OCA: Protected "6hcx" [edit=sysop:move=sysop]

OCA — Wed, 22 Aug 2018 04:58:04 GMT

Protected "6hcx" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 22 August 2018

OCA: New page: '''Unreleased structure''' The entry 6hcx is ON HOLD Authors: Salinger, M.T., Hobbs, J.R., Murray, J.M., Laver, W.G., Kuhn, P., Garman, E.F. Description: Influenza Virus N9 Neuraminida...

OCA — Wed, 22 Aug 2018 04:58:03 GMT

New page: '''Unreleased structure''' The entry 6hcx is ON HOLD Authors: Salinger, M.T., Hobbs, J.R., Murray, J.M., Laver, W.G., Kuhn, P., Garman, E.F. Description: Influenza Virus N9 Neuraminida...

New page

'''Unreleased structure'''

The entry 6hcx is ON HOLD

Authors: Salinger, M.T., Hobbs, J.R., Murray, J.M., Laver, W.G., Kuhn, P., Garman, E.F.

Description: Influenza Virus N9 Neuraminidase A complex with Zanamivir molecule (Tern).
[[Category: Unreleased Structures]]
[[Category: Garman, E.F]]
[[Category: Hobbs, J.R]]
[[Category: Kuhn, P]]
[[Category: Laver, W.G]]
[[Category: Salinger, M.T]]
[[Category: Murray, J.M]]