OCA at 15:25, 28 August 2019

OCA — Wed, 28 Aug 2019 15:25:03 GMT

←Older revision		Revision as of 15:25, 28 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6hey ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative ATNK002==
-		+	<StructureSection load='6hey' size='340' side='right'caption='[[6hey]], [[Resolution\|resolution]] 1.37Å' scene=''>
-	~~Authors~~: ~~Kudlinzki, D~~., ~~Troester~~, A., ~~Witt~~, K., ~~Linhard~~, V.L., ~~Gande~~, S.L., ~~Saxena~~, K., ~~Schwalbe~~, H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6hey]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HEY FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure~~ of ~~Ephrin A2~~ (~~EphA2~~) ~~Receptor Protein Kinase with~~ the ~~NVP~~-~~BHG712 derivative ATNK002~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FZW:3-[(4,6-dipyridin-3-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide'>FZW</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	[[Category: ~~Linhard~~, V.L]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hey OCA], [http://pdbe.org/6hey PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hey RCSB], [http://www.ebi.ac.uk/pdbsum/6hey PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hey ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[http://omim.org/entry/613020 613020]]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.<ref>PMID:19573808</ref> <ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[http://omim.org/entry/116600 116600]]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:19573808</ref> <ref>PMID:19005574</ref> <ref>PMID:19306328</ref> <ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.<ref>PMID:19573808</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.<ref>PMID:10655584</ref> <ref>PMID:16236711</ref> <ref>PMID:18339848</ref> <ref>PMID:19573808</ref> <ref>PMID:20679435</ref> <ref>PMID:20861311</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Receptor protein-tyrosine kinase]]
		+	[[Category: Gande, S L]]
	[[Category: Kudlinzki, D]]		[[Category: Kudlinzki, D]]
		+	[[Category: Linhard, V L]]
	[[Category: Saxena, K]]		[[Category: Saxena, K]]
-	[[Category: Witt, K]]
-	[[Category: Gande, S.L]]
	[[Category: Schwalbe, H]]		[[Category: Schwalbe, H]]
	[[Category: Troester, A]]		[[Category: Troester, A]]
		+	[[Category: Witt, K]]
		+	[[Category: Complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Protein tyrosine kinase]]
		+	[[Category: Transferase]]

OCA: Protected "6hey" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2018 05:54:45 GMT

Protected "6hey" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:54, 29 August 2018

OCA: New page: '''Unreleased structure''' The entry 6hey is ON HOLD until Paper Publication Authors: Kudlinzki, D., Troester, A., Witt, K., Linhard, V.L., Gande, S.L., Saxena, K., Schwalbe, H. Descri...

OCA — Wed, 29 Aug 2018 05:54:44 GMT

New page: '''Unreleased structure''' The entry 6hey is ON HOLD until Paper Publication Authors: Kudlinzki, D., Troester, A., Witt, K., Linhard, V.L., Gande, S.L., Saxena, K., Schwalbe, H. Descri...

New page

'''Unreleased structure'''

The entry 6hey is ON HOLD until Paper Publication

Authors: Kudlinzki, D., Troester, A., Witt, K., Linhard, V.L., Gande, S.L., Saxena, K., Schwalbe, H.

Description: Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative ATNK002
[[Category: Unreleased Structures]]
[[Category: Linhard, V.L]]
[[Category: Kudlinzki, D]]
[[Category: Saxena, K]]
[[Category: Witt, K]]
[[Category: Gande, S.L]]
[[Category: Schwalbe, H]]
[[Category: Troester, A]]

6hey - Revision history

OCA at 15:25, 28 August 2019

OCA: Protected "6hey" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6hey is ON HOLD until Paper Publication Authors: Kudlinzki, D., Troester, A., Witt, K., Linhard, V.L., Gande, S.L., Saxena, K., Schwalbe, H. Descri...