6hft - Revision history

OCA at 06:51, 17 April 2019

OCA — Wed, 17 Apr 2019 06:51:54 GMT

←Older revision		Revision as of 06:51, 17 April 2019
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	<StructureSection load='6hft' size='340' side='right'caption='[[6hft]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6hft' size='340' side='right'caption='[[6hft]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hft]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HFT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hfm\|6hfm]], [[6hfo\|6hfo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hfm\|6hfm]], [[6hfo\|6hfo]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CNS1, YBR155W, YBR1205 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hft OCA], [http://pdbe.org/6hft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hft RCSB], [http://www.ebi.ac.uk/pdbsum/6hft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hft ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hft OCA], [http://pdbe.org/6hft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hft RCSB], [http://www.ebi.ac.uk/pdbsum/6hft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hft ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Groll, M]]		[[Category: Groll, M]]

OCA at 06:38, 27 March 2019

OCA — Wed, 27 Mar 2019 06:38:22 GMT

←Older revision		Revision as of 06:38, 27 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6hft is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae (delta69)==
		+	<StructureSection load='6hft' size='340' side='right'caption='[[6hft]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hft]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HFT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hfm\|6hfm]], [[6hfo\|6hfo]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hft OCA], [http://pdbe.org/6hft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hft RCSB], [http://www.ebi.ac.uk/pdbsum/6hft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hft ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CNS1_YEAST CNS1_YEAST]] Co-chaperone that binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. Involved in only a subset of Hsp90 functions.<ref>PMID:12788914</ref> <ref>PMID:15044454</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast, but its structure and function remained unknown. Here, we report the X-ray structure of the Cns1 fold and NMR studies on the partly disordered, essential segment of the protein. We demonstrate that Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90. The in vivo folding and solubility of eEF2 depend on the presence of these proteins. Chaperoning of eEF2 by Cns1 is essential for yeast viability and requires a defined subset of the Hsp90 machinery as well as the identified eEF2 recruiting factor Hgh1.

-	~~Authors~~:	+	The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.,Schopf FH, Huber EM, Dodt C, Lopez A, Biebl MM, Rutz DA, Muhlhofer M, Richter G, Madl T, Sattler M, Groll M, Buchner J Mol Cell. 2019 Mar 8. pii: S1097-2765(19)30101-7. doi:, 10.1016/j.molcel.2019.02.011. PMID:30876805<ref>PMID:30876805</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6hft" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Groll, M]]
		+	[[Category: Huber, E M]]
		+	[[Category: Chaperone]]
		+	[[Category: Hsp90 co-chaperone]]
		+	[[Category: Tpr domain]]
		+	[[Category: Two-domain fold]]
		+	[[Category: Wheel domain]]

OCA at 08:43, 5 September 2018

OCA — Wed, 05 Sep 2018 08:43:50 GMT

←Older revision		Revision as of 08:43, 5 September 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6hft is ON HOLD	+	The entry 6hft is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6hft" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2018 05:59:56 GMT

Protected "6hft" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:59, 29 August 2018

OCA: New page: '''Unreleased structure''' The entry 6hft is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Aug 2018 05:59:55 GMT

New page: '''Unreleased structure''' The entry 6hft is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6hft is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]