OCA at 05:48, 7 August 2019

OCA — Wed, 07 Aug 2019 05:48:31 GMT

←Older revision		Revision as of 05:48, 7 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6hgw ~~is ON HOLD~~	+	==Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-N-(4-phenoxybenzyl)ethanamine==
-		+	<StructureSection load='6hgw' size='340' side='right'caption='[[6hgw]], [[Resolution\|resolution]] 2.41Å' scene=''>
-	~~Authors~~: ~~Kramer, J~~.S.~~, Pogoryelov, D~~.~~, Hiesinger, K~~.~~, Proschak, E~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6hgw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HGW FirstGlance]. <br>
-	~~Description~~: ~~Soluble epoxide hydrolase in complex with~~ 2-(4-fluorophenyl)-N-(4-~~phenoxybenzyl~~)ethanamine	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3W:2-(4-fluorophenyl)-~{N}-[(4-phenoxyphenyl)methyl]ethanamine'>G3W</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hgw OCA], [http://pdbe.org/6hgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hgw RCSB], [http://www.ebi.ac.uk/pdbsum/6hgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hgw ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Proschak~~, E]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hiesinger, K]]		[[Category: Hiesinger, K]]
		+	[[Category: Kramer, J S]]
	[[Category: Pogoryelov, D]]		[[Category: Pogoryelov, D]]
-	[[Category: ~~Kramer~~, ~~J.S~~]]	+	[[Category: Proschak, E]]
		+	[[Category: Complex]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]
		+	[[Category: Seh]]

OCA: Protected "6hgw" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2018 06:02:34 GMT

Protected "6hgw" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:02, 29 August 2018

OCA: New page: '''Unreleased structure''' The entry 6hgw is ON HOLD Authors: Kramer, J.S., Pogoryelov, D., Hiesinger, K., Proschak, E. Description: Soluble epoxide hydrolase in complex with 2-(4-fluo...

OCA — Wed, 29 Aug 2018 06:02:32 GMT

New page: '''Unreleased structure''' The entry 6hgw is ON HOLD Authors: Kramer, J.S., Pogoryelov, D., Hiesinger, K., Proschak, E. Description: Soluble epoxide hydrolase in complex with 2-(4-fluo...

New page

'''Unreleased structure'''

The entry 6hgw is ON HOLD

Authors: Kramer, J.S., Pogoryelov, D., Hiesinger, K., Proschak, E.

Description: Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-N-(4-phenoxybenzyl)ethanamine
[[Category: Unreleased Structures]]
[[Category: Proschak, E]]
[[Category: Hiesinger, K]]
[[Category: Pogoryelov, D]]
[[Category: Kramer, J.S]]

6hgw - Revision history

OCA at 05:48, 7 August 2019

OCA: Protected "6hgw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6hgw is ON HOLD Authors: Kramer, J.S., Pogoryelov, D., Hiesinger, K., Proschak, E. Description: Soluble epoxide hydrolase in complex with 2-(4-fluo...