6hj7 - Revision history

OCA at 10:50, 14 June 2023

OCA — Wed, 14 Jun 2023 10:50:21 GMT

←Older revision		Revision as of 10:50, 14 June 2023
Line 1:		Line 1:

	==The NMR structure of NRADD death domain==		==The NMR structure of NRADD death domain==
-	<StructureSection load='6hj7' size='340' side='right'caption='[[6hj7~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6hj7' size='340' side='right'caption='[[6hj7]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hj7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6HJ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hj7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HJ7 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nradd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj7 OCA], [https://pdbe.org/6hj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hj7 RCSB], [https://www.ebi.ac.uk/pdbsum/6hj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj7 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj7 OCA], [~~http~~://pdbe.org/6hj7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6hj7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6hj7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NRADD_MOUSE NRADD_MOUSE]] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.<ref>PMID:12728256</ref> <ref>PMID:12843241</ref> <ref>PMID:19407813</ref>	+	[https://www.uniprot.org/uniprot/NRADD_MOUSE NRADD_MOUSE] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.<ref>PMID:12728256</ref> <ref>PMID:12843241</ref> <ref>PMID:19407813</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Arseniev~~, A S~~]]	+	[[Category: Arseniev AS]]
-	[[Category: Goncharuk~~, S A~~]]	+	[[Category: Goncharuk SA]]
-	[[Category: Mineev~~, K S~~]]	+	[[Category: Mineev KS]]
-	[[Category: Nadezhdin~~, K D]]~~	+	[[Category: Nadezhdin KD]]
-	~~[[Category: Bicelle]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Nraad]]~~	+
-	~~[[Category: P45]]~~	+
-	~~[[Category: P75 neurotrophin receptor~~]]	+

OCA at 17:20, 14 August 2019

OCA — Wed, 14 Aug 2019 17:20:05 GMT

←Older revision		Revision as of 17:20, 14 August 2019
Line 3:		Line 3:
	<StructureSection load='6hj7' size='340' side='right'caption='[[6hj7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6hj7' size='340' side='right'caption='[[6hj7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hj7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJ7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj7 OCA], [http://pdbe.org/6hj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hj7 RCSB], [http://www.ebi.ac.uk/pdbsum/6hj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj7 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nradd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj7 OCA], [http://pdbe.org/6hj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hj7 RCSB], [http://www.ebi.ac.uk/pdbsum/6hj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Arseniev, A S]]		[[Category: Arseniev, A S]]
	[[Category: Goncharuk, S A]]		[[Category: Goncharuk, S A]]

OCA at 11:18, 10 May 2019

OCA — Fri, 10 May 2019 11:18:27 GMT

←Older revision		Revision as of 11:18, 10 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6hj7 is ~~ON HOLD~~	+	==The NMR structure of NRADD death domain==
		+	<StructureSection load='6hj7' size='340' side='right'caption='[[6hj7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hj7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJ7 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj7 OCA], [http://pdbe.org/6hj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hj7 RCSB], [http://www.ebi.ac.uk/pdbsum/6hj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj7 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NRADD_MOUSE NRADD_MOUSE]] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.<ref>PMID:12728256</ref> <ref>PMID:12843241</ref> <ref>PMID:19407813</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structural study of any single-pass membrane protein is both an important and challenging task. In this report, we present the structure of a neurotrophin receptor-alike death-domain protein, NRADD. The structure and dynamics of the protein was investigated by conventional nuclear magnetic resonance techniques in the solution of phospholipid bicelles. The receptor contains two folded regions - alpha-helical transmembrane domain and globular C-terminal death domain with more than 50% of the rest of backbone being disordered. This is the first structure of a full-length single-pass membrane receptor-alike protein solved by the single method. This article is protected by copyright. All rights reserved.

-	~~Authors:~~ Nadezhdin, ~~K.D.~~, Mineev~~, K~~.S.~~, Goncharuk, S~~.A.~~, Arseniev, A.S~~.	+	NMR structure of a full-length single-pass membrane protein NRADD.,Nadezhdin KD, Goncharuk SA, Arseniev AS, Mineev KS Proteins. 2019 Apr 29. doi: 10.1002/prot.25703. PMID:31033000<ref>PMID:31033000</ref>

-	~~Description: The NMR structure~~ of ~~NRADD death domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Mineev~~, K.S]]	+	<div class="pdbe-citations 6hj7" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Arseniev~~, A.S]]	+	== References ==
-	[[Category: Nadezhdin, K.D]]	+	<references/>
-	[[Category: ~~Goncharuk, S.A~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arseniev, A S]]
		+	[[Category: Goncharuk, S A]]
		+	[[Category: Mineev, K S]]
		+	[[Category: Nadezhdin, K D]]
		+	[[Category: Bicelle]]
		+	[[Category: Membrane protein]]
		+	[[Category: Nraad]]
		+	[[Category: P45]]
		+	[[Category: P75 neurotrophin receptor]]

OCA: Protected "6hj7" [edit=sysop:move=sysop]

OCA — Wed, 12 Sep 2018 06:03:14 GMT

Protected "6hj7" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:03, 12 September 2018

OCA: New page: '''Unreleased structure''' The entry 6hj7 is ON HOLD Authors: Nadezhdin, K.D., Mineev, K.S., Goncharuk, S.A., Arseniev, A.S. Description: The NMR structure of NRADD death domain [[Cate...

OCA — Wed, 12 Sep 2018 06:03:13 GMT

New page: '''Unreleased structure''' The entry 6hj7 is ON HOLD Authors: Nadezhdin, K.D., Mineev, K.S., Goncharuk, S.A., Arseniev, A.S. Description: The NMR structure of NRADD death domain [[Cate...

New page

'''Unreleased structure'''

The entry 6hj7 is ON HOLD

Authors: Nadezhdin, K.D., Mineev, K.S., Goncharuk, S.A., Arseniev, A.S.

Description: The NMR structure of NRADD death domain
[[Category: Unreleased Structures]]
[[Category: Mineev, K.S]]
[[Category: Arseniev, A.S]]
[[Category: Nadezhdin, K.D]]
[[Category: Goncharuk, S.A]]