6hjn - Revision history

OCA at 01:25, 11 April 2020

OCA — Sat, 11 Apr 2020 01:25:18 GMT

←Older revision		Revision as of 01:25, 11 April 2020
Line 3:		Line 3:
	<SX load='6hjn' size='340' side='right' viewer='molstar' caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>		<SX load='6hjn' size='340' side='right' viewer='molstar' caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I76a4 I76a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6HJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I76a4 I76a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6HJN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPL:UNKNOWN+BRANCHED+FRAGMENT+OF+PHOSPHOLIPID'>UPL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPL:UNKNOWN+BRANCHED+FRAGMENT+OF+PHOSPHOLIPID'>UPL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjn OCA], [http://pdbe.org/6hjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hjn RCSB], [http://www.ebi.ac.uk/pdbsum/6hjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6hjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjn OCA], [http://pdbe.org/6hjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hjn RCSB], [http://www.ebi.ac.uk/pdbsum/6hjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:52, 6 March 2020

OCA — Fri, 06 Mar 2020 21:52:56 GMT

←Older revision		Revision as of 21:52, 6 March 2020
Line 1:		Line 1:

	==Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76)==		==Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76)==
-	<~~StructureSection~~ load='6hjn' size='340' side='right'caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<SX load='6hjn' size='340' side='right' viewer='molstar' caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I76a4 I76a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJN FirstGlance]. <br>		<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I76a4 I76a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJN FirstGlance]. <br>
Line 24:		Line 24:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: I76a4]]		[[Category: I76a4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 18:28, 11 December 2019

OCA — Wed, 11 Dec 2019 18:28:10 GMT

←Older revision		Revision as of 18:28, 11 December 2019
Line 1:		Line 1:

	==Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76)==		==Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76)==
-	<StructureSection load='6hjn' size='340' side='right' caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='6hjn' size='340' side='right'caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I76a4 I76a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJN FirstGlance]. <br>		<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I76a4 I76a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJN FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6hjn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6hjn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: I76a4]]		[[Category: I76a4]]
		+	[[Category: Large Structures]]
	[[Category: Benton, D J]]		[[Category: Benton, D J]]
	[[Category: Rosenthal, P B]]		[[Category: Rosenthal, P B]]

OCA at 08:41, 10 October 2018

OCA — Wed, 10 Oct 2018 08:41:39 GMT

←Older revision		Revision as of 08:41, 10 October 2018
Line 3:		Line 3:
	<StructureSection load='6hjn' size='340' side='right' caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6hjn' size='340' side='right' caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus_(strain_a/duck/alberta/35/1976_h1n1) Influenza a virus (strain a/duck/alberta/35/1976 h1n1)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I76a4 I76a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPL:UNKNOWN+BRANCHED+FRAGMENT+OF+PHOSPHOLIPID'>UPL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPL:UNKNOWN+BRANCHED+FRAGMENT+OF+PHOSPHOLIPID'>UPL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjn OCA], [http://pdbe.org/6hjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hjn RCSB], [http://www.ebi.ac.uk/pdbsum/6hjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjn OCA], [http://pdbe.org/6hjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hjn RCSB], [http://www.ebi.ac.uk/pdbsum/6hjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjn ProSAT]</span></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: I76a4]]
	[[Category: Benton, D J]]		[[Category: Benton, D J]]
	[[Category: Rosenthal, P B]]		[[Category: Rosenthal, P B]]

OCA at 08:21, 26 September 2018

OCA — Wed, 26 Sep 2018 08:21:45 GMT

←Older revision		Revision as of 08:21, 26 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6hjn is ~~ON HOLD~~	+	==Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76)==
		+	<StructureSection load='6hjn' size='340' side='right' caption='[[6hjn]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hjn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(strain_a/duck/alberta/35/1976_h1n1) Influenza a virus (strain a/duck/alberta/35/1976 h1n1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPL:UNKNOWN+BRANCHED+FRAGMENT+OF+PHOSPHOLIPID'>UPL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjn OCA], [http://pdbe.org/6hjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hjn RCSB], [http://www.ebi.ac.uk/pdbsum/6hjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjn ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9WCE0_I76A4 Q9WCE0_I76A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643] [[http://www.uniprot.org/uniprot/HEMA_I76A4 HEMA_I76A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies. The soluble ectodomain fragments used in these studies lacked the "membrane anchor" portion of the molecule. Since this region has a role in membrane fusion, we have determined its structure by analyzing the intact, full-length molecule in a detergent micelle, using cryo-EM. We have also compared the structures of full-length HA-detergent micelles with full-length HA-Fab complex detergent micelles, to describe an infectivity-neutralizing monoclonal Fab that binds near the ectodomain membrane anchor junction. We determine a high-resolution HA structure which compares favorably in detail with the structure of the ectodomain seen by X-ray crystallography; we detect, clearly, all five carbohydrate side chains of HA; and we find that the ectodomain is joined to the membrane anchor by flexible, eight-residue-long, linkers. The linkers extend into the detergent micelle to join a central triple-helical structure that is a major component of the membrane anchor.

-	~~Authors:~~ Benton, D.J., Rosenthal, P.B.	+	Influenza hemagglutinin membrane anchor.,Benton DJ, Nans A, Calder LJ, Turner J, Neu U, Lin YP, Ketelaars E, Kallewaard NL, Corti D, Lanzavecchia A, Gamblin SJ, Rosenthal PB, Skehel JJ Proc Natl Acad Sci U S A. 2018 Sep 17. pii: 1810927115. doi:, 10.1073/pnas.1810927115. PMID:30224494<ref>PMID:30224494</ref>

-	~~Description: Structure~~ of ~~Influenza Hemagglutinin ectodomain (A~~/~~duck~~/~~Alberta~~/35/~~76)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Rosenthal, P.B]]	+	<div class="pdbe-citations 6hjn" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Benton, D.J~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Benton, D J]]
		+	[[Category: Rosenthal, P B]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Influenza virus]]
		+	[[Category: Membrane fusion]]
		+	[[Category: Membrane protein]]
		+	[[Category: Viral protein]]

OCA: Protected "6hjn" [edit=sysop:move=sysop]

OCA — Wed, 12 Sep 2018 06:04:26 GMT

Protected "6hjn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:04, 12 September 2018

OCA: New page: '''Unreleased structure''' The entry 6hjn is ON HOLD Authors: Benton, D.J., Rosenthal, P.B. Description: Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76) [[Catego...

OCA — Wed, 12 Sep 2018 06:04:24 GMT

New page: '''Unreleased structure''' The entry 6hjn is ON HOLD Authors: Benton, D.J., Rosenthal, P.B. Description: Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76) [[Catego...

New page

'''Unreleased structure'''

The entry 6hjn is ON HOLD

Authors: Benton, D.J., Rosenthal, P.B.

Description: Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76)
[[Category: Unreleased Structures]]
[[Category: Rosenthal, P.B]]
[[Category: Benton, D.J]]