6hku - Revision history

OCA at 07:32, 23 May 2019

OCA — Thu, 23 May 2019 07:32:20 GMT

←Older revision		Revision as of 07:32, 23 May 2019
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	<StructureSection load='6hku' size='340' side='right'caption='[[6hku]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='6hku' size='340' side='right'caption='[[6hku]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hku]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hku]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Tspyv Tspyv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=862909 TSPyV])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hku OCA], [http://pdbe.org/6hku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hku RCSB], [http://www.ebi.ac.uk/pdbsum/6hku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hku ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hku OCA], [http://pdbe.org/6hku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hku RCSB], [http://www.ebi.ac.uk/pdbsum/6hku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hku ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Tspyv]]
	[[Category: Rustmeier, N H]]		[[Category: Rustmeier, N H]]
	[[Category: Stehle, T]]		[[Category: Stehle, T]]
	[[Category: Sialic acid derivative]]		[[Category: Sialic acid derivative]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 06:38, 27 March 2019

OCA — Wed, 27 Mar 2019 06:38:42 GMT

←Older revision		Revision as of 06:38, 27 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6hku is ~~ON HOLD until Paper~~ Publication	+	==Trichodysplasia spinulosa-associated polyomavirus (TSPyV) VP1 in complex with sialylated precision glycooligomers==
		+	<StructureSection load='6hku' size='340' side='right'caption='[[6hku]], [[Resolution\|resolution]] 1.98Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hku]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hku OCA], [http://pdbe.org/6hku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hku RCSB], [http://www.ebi.ac.uk/pdbsum/6hku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hku ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Divalent precision glycooligomers terminating in N-acetylneuraminic acid (Neu5Ac) or 3'-sialyllactose (3'-SL) with varying linkers between scaffold and the glycan portions are synthesized via solid phase synthesis for co-crystallization studies with the sialic acid-binding major capsid protein VP1 of human Trichodysplasia spinulosa-associated Polyomavirus. High-resolution crystal structures of complexes demonstrate that the compounds bind to VP1 depending on the favorable combination of carbohydrate ligand and linker. It is found that artificial linkers can replace portions of natural carbohydrate linkers as long as they meet certain requirements such as size or flexibility to optimize contact area between ligand and receptor binding sites. The obtained results will influence the design of future high affinity ligands based on the structures presented here, and they can serve as a blueprint to develop multivalent glycooligomers as inhibitors of viral adhesion.

-	~~Authors~~:	+	Divalent Sialylated Precision Glycooligomers Binding to Polyomaviruses and the Effect of Different Linkers.,Baier M, Rustmeier NH, Harr J, Cyrus N, Reiss GJ, Grafmuller A, Blaum BS, Stehle T, Hartmann L Macromol Biosci. 2019 Mar 18:e1800426. doi: 10.1002/mabi.201800426. PMID:30884172<ref>PMID:30884172</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6hku" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rustmeier, N H]]
		+	[[Category: Stehle, T]]
		+	[[Category: Sialic acid derivative]]
		+	[[Category: Viral protein]]

OCA at 05:59, 30 January 2019

OCA — Wed, 30 Jan 2019 05:59:34 GMT

←Older revision		Revision as of 05:59, 30 January 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6hku is ON HOLD	+	The entry 6hku is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6hku" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2018 18:09:42 GMT

Protected "6hku" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:09, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6hku is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Sep 2018 18:09:41 GMT

New page: '''Unreleased structure''' The entry 6hku is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6hku is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]