6hkw - Revision history

OCA at 11:01, 30 March 2022

OCA — Wed, 30 Mar 2022 11:01:27 GMT

←Older revision		Revision as of 11:01, 30 March 2022
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	<StructureSection load='6hkw' size='340' side='right'caption='[[6hkw]], [[Resolution\|resolution]] 3.09Å' scene=''>		<StructureSection load='6hkw' size='340' side='right'caption='[[6hkw]], [[Resolution\|resolution]] 3.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hkw]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6HKW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hkw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HKW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP1R7, SDS22 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP1R7, SDS22 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkw OCA], [~~http~~://pdbe.org/6hkw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6hkw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6hkw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkw OCA], [https://pdbe.org/6hkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hkw RCSB], [https://www.ebi.ac.uk/pdbsum/6hkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PP1R7_HUMAN PP1R7_HUMAN]] Regulatory subunit of protein phosphatase 1.	+	[[https://www.uniprot.org/uniprot/PP1R7_HUMAN PP1R7_HUMAN]] Regulatory subunit of protein phosphatase 1.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6hkw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6hkw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:41, 13 March 2019

OCA — Wed, 13 Mar 2019 12:41:39 GMT

←Older revision		Revision as of 12:41, 13 March 2019
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	==Crystal structure of human SDS22==		==Crystal structure of human SDS22==
-	<StructureSection load='6hkw' size='340' side='right' caption='[[6hkw]], [[Resolution\|resolution]] 3.09Å' scene=''>	+	<StructureSection load='6hkw' size='340' side='right'caption='[[6hkw]], [[Resolution\|resolution]] 3.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hkw]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hkw]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP1R7, SDS22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkw OCA], [http://pdbe.org/6hkw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hkw RCSB], [http://www.ebi.ac.uk/pdbsum/6hkw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkw OCA], [http://pdbe.org/6hkw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hkw RCSB], [http://www.ebi.ac.uk/pdbsum/6hkw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkw ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bollen, M]]		[[Category: Bollen, M]]
	[[Category: Choy, M S]]		[[Category: Choy, M S]]

OCA at 08:27, 30 January 2019

OCA — Wed, 30 Jan 2019 08:27:09 GMT

←Older revision		Revision as of 08:27, 30 January 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6hkw is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human SDS22==
		+	<StructureSection load='6hkw' size='340' side='right' caption='[[6hkw]], [[Resolution\|resolution]] 3.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hkw]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkw OCA], [http://pdbe.org/6hkw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hkw RCSB], [http://www.ebi.ac.uk/pdbsum/6hkw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PP1R7_HUMAN PP1R7_HUMAN]] Regulatory subunit of protein phosphatase 1.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SDS22 is an ancient regulator of protein phosphatase-1 (PP1). Our crystal structure of SDS22 shows that its twelve leucine-rich repeats adopt a banana-shaped fold that is shielded from solvent by capping domains at its extremities. Subsequent modeling and biochemical studies revealed that the concave side of SDS22 likely interacts with PP1 helices alpha5 and alpha6, which are distal from the binding sites of many previously described PP1 interactors. Accordingly, we found that SDS22 acts as a "third" subunit of multiple PP1 holoenzymes. The crystal structure of SDS22 also revealed a large basic surface patch that enables binding of a phosphorylated form of splicing factor BCLAF1. Taken together, our data provide insights into the formation of PP1:SDS22 and the recruitment of additional interaction proteins, such as BCLAF1.

-	~~Authors~~:	+	Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.,Heroes E, Van der Hoeven G, Choy MS, Garcia JDP, Ferreira M, Nys M, Derua R, Beullens M, Ulens C, Peti W, Van Meervelt L, Page R, Bollen M Structure. 2018 Dec 17. pii: S0969-2126(18)30458-1. doi:, 10.1016/j.str.2018.12.002. PMID:30661852<ref>PMID:30661852</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6hkw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bollen, M]]
		+	[[Category: Choy, M S]]
		+	[[Category: Heroes, E]]
		+	[[Category: Meervelt, L Van]]
		+	[[Category: Nys, M]]
		+	[[Category: Page, R]]
		+	[[Category: Peti, W]]
		+	[[Category: Ulens, C]]
		+	[[Category: Lrr protein]]
		+	[[Category: Pp1 regulator]]
		+	[[Category: Signaling protein]]

OCA at 06:12, 17 October 2018

OCA — Wed, 17 Oct 2018 06:12:13 GMT

←Older revision		Revision as of 06:12, 17 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6hkw is ON HOLD	+	The entry 6hkw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6hkw" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2018 18:09:48 GMT

Protected "6hkw" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:09, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6hkw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Sep 2018 18:09:47 GMT

New page: '''Unreleased structure''' The entry 6hkw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6hkw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]