OCA at 11:33, 24 January 2024

OCA — Wed, 24 Jan 2024 11:33:28 GMT

←Older revision		Revision as of 11:33, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6hn8' size='340' side='right'caption='[[6hn8]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6hn8' size='340' side='right'caption='[[6hn8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hn8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HN8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=6HN8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hn8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HN8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TDZ:(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE'>TDZ~~</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.997Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASX:ASP/ASN+AMBIGUOUS'>ASX~~</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASX:ASP/ASN+AMBIGUOUS'>ASX</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TDZ:(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE'>TDZ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hn8 OCA], [~~http~~://pdbe.org/6hn8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6hn8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6hn8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6hn8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hn8 OCA], [https://pdbe.org/6hn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hn8 RCSB], [https://www.ebi.ac.uk/pdbsum/6hn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hn8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CPXB_PRIM2 CPXB_PRIM2] Functions as a fatty acid monooxygenase (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Jeffreys, L~~]]	+	[[Category: Priestia megaterium]]
-	[[Category: ~~Leys, D~~]]	+	[[Category: Jeffreys L]]
-	[[Category: ~~Munro, A W.M~~]]	+	[[Category: Leys D]]
-	[[Category: ~~Antidiabetic]]~~	+	[[Category: Munro AWM]]
-	~~[[Category: Cytochrome p450]]~~	+
-	~~[[Category: Heme binding]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Troglitazone~~]]	+

OCA at 05:14, 10 October 2019

OCA — Thu, 10 Oct 2019 05:14:40 GMT

←Older revision		Revision as of 05:14, 10 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6hn8 ~~is ON HOLD~~	+	==Structure of BM3 heme domain in complex with troglitazone==
-		+	<StructureSection load='6hn8' size='340' side='right'caption='[[6hn8]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6hn8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HN8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TDZ:(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE'>TDZ</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASX:ASP/ASN+AMBIGUOUS'>ASX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hn8 OCA], [http://pdbe.org/6hn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hn8 RCSB], [http://www.ebi.ac.uk/pdbsum/6hn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hn8 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Jeffreys, L]]
		+	[[Category: Leys, D]]
		+	[[Category: Munro, A W.M]]
		+	[[Category: Antidiabetic]]
		+	[[Category: Cytochrome p450]]
		+	[[Category: Heme binding]]
		+	[[Category: Monooxygenase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Troglitazone]]

OCA: Protected "6hn8" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2018 18:16:26 GMT

Protected "6hn8" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:16, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6hn8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Sep 2018 18:16:24 GMT

New page: '''Unreleased structure''' The entry 6hn8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6hn8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6hn8 - Revision history

OCA at 11:33, 24 January 2024

OCA at 05:14, 10 October 2019

OCA: Protected "6hn8" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6hn8 is ON HOLD Authors: Description: Category: Unreleased Structures