6hox - Revision history

OCA at 11:35, 24 January 2024

OCA — Wed, 24 Jan 2024 11:35:31 GMT

←Older revision		Revision as of 11:35, 24 January 2024
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	<StructureSection load='6hox' size='340' side='right'caption='[[6hox]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='6hox' size='340' side='right'caption='[[6hox]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hox]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HOX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6HOX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paraclostridium_bifermentans Paraclostridium bifermentans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HOX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hox OCA], [~~http~~://pdbe.org/6hox PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6hox RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6hox PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6hox ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hox OCA], [https://pdbe.org/6hox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hox RCSB], [https://www.ebi.ac.uk/pdbsum/6hox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hox ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A5P3XKQ1_PARBF A0A5P3XKQ1_PARBF]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Masuyer, G~~]]	+	[[Category: Paraclostridium bifermentans]]
-	[[Category: ~~Stenmark, P~~]]	+	[[Category: Masuyer G]]
-	[[Category: ~~Anophele]]~~	+	[[Category: Stenmark P]]
-	~~[[Category: Botulinum]]~~	+
-	~~[[Category: Neurotoxin]]~~	+
-	~~[[Category: Paraclostridium bifermentan]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 05:43, 10 July 2019

OCA — Wed, 10 Jul 2019 05:43:45 GMT

←Older revision		Revision as of 05:43, 10 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6hox is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the binding domain of Paraclostridial Mosquitocidal Protein 1==
		+	<StructureSection load='6hox' size='340' side='right'caption='[[6hox]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hox]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HOX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hox OCA], [http://pdbe.org/6hox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hox RCSB], [http://www.ebi.ac.uk/pdbsum/6hox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hox ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution of clostridial neurotoxins and provides the basis for the use of P. bifermentans strains and PMP1 as innovative, environmentally friendly approaches to reduce malaria through anopheline control.

-	~~Authors~~:	+	A neurotoxin that specifically targets Anopheles mosquitoes.,Contreras E, Masuyer G, Qureshi N, Chawla S, Dhillon HS, Lee HL, Chen J, Stenmark P, Gill SS Nat Commun. 2019 Jun 28;10(1):2869. doi: 10.1038/s41467-019-10732-w. PMID:31253776<ref>PMID:31253776</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6hox" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Masuyer, G]]
		+	[[Category: Stenmark, P]]
		+	[[Category: Anophele]]
		+	[[Category: Botulinum]]
		+	[[Category: Neurotoxin]]
		+	[[Category: Paraclostridium bifermentan]]
		+	[[Category: Toxin]]

OCA at 06:10, 10 October 2018

OCA — Wed, 10 Oct 2018 06:10:55 GMT

←Older revision		Revision as of 06:10, 10 October 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6hox is ON HOLD	+	The entry 6hox is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6hox" [edit=sysop:move=sysop]

OCA — Wed, 26 Sep 2018 06:16:26 GMT

Protected "6hox" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:16, 26 September 2018

OCA: New page: '''Unreleased structure''' The entry 6hox is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Sep 2018 06:16:25 GMT

New page: '''Unreleased structure''' The entry 6hox is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6hox is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]