6hpz - Revision history

OCA at 11:36, 24 January 2024

OCA — Wed, 24 Jan 2024 11:36:55 GMT

←Older revision		Revision as of 11:36, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6hpz' size='340' side='right'caption='[[6hpz]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6hpz' size='340' side='right'caption='[[6hpz]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hpz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6HPZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HPZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=ALY:N(6)~~-~~ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6hpw\|6hpw]], [[6hpx\|6hpx]], [[6hpy\|6hpy]], [[6hq0\|6hq0]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MLLT1, ENL, LTG19, YEATS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpz OCA], [https://pdbe.org/6hpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hpz RCSB], [https://www.ebi.ac.uk/pdbsum/6hpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpz OCA], [~~http~~://pdbe.org/6hpz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6hpz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6hpz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.	+	[https://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>	+	[https://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Chaikuad, A]]	+	[[Category: Chaikuad A]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: Heidenreich, D]]	+	[[Category: Heidenreich D]]
-	[[Category: Knapp, S]]	+	[[Category: Knapp S]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Yeats domain~~]]	+

OCA at 07:58, 24 April 2019

OCA — Wed, 24 Apr 2019 07:58:31 GMT

←Older revision		Revision as of 07:58, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of ENL (MLLT1) in complex with acetyllysine==		==Crystal structure of ENL (MLLT1) in complex with acetyllysine==
-	<StructureSection load='6hpz' size='340' side='right' caption='[[6hpz]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='6hpz' size='340' side='right'caption='[[6hpz]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6hpz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HPZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6hpz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HPZ FirstGlance]. <br>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 20:34, 2 December 2018

OCA — Sun, 02 Dec 2018 20:34:04 GMT

←Older revision		Revision as of 20:34, 2 December 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6hpz is ~~ON HOLD~~	+	==Crystal structure of ENL (MLLT1) in complex with acetyllysine==
		+	<StructureSection load='6hpz' size='340' side='right' caption='[[6hpz]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hpz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HPZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hpw\|6hpw]], [[6hpx\|6hpx]], [[6hpy\|6hpy]], [[6hq0\|6hq0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLLT1, ENL, LTG19, YEATS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpz OCA], [http://pdbe.org/6hpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hpz RCSB], [http://www.ebi.ac.uk/pdbsum/6hpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpz ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lysine acetylation is an epigenetic mark that is principally recognized by bromodomains, and recently structurally diverse YEATS domains also emerged as readers of lysine acetyl/acylations. Here we present a crystallography-based strategy and the discovery of fragments binding to the ENL YEATS domain, a potential drug target. Crystal structures combined with synthetic efforts led to the identification of a submicromolar binder, providing first starting points for the development of chemical probes for this reader domain family.

-	~~Authors:~~ Heidenreich, D., ~~Chaikuad~~, A., ~~Arrowsmith~~, ~~C.H.~~, ~~Edwards~~, A~~.M., Bountra, C.~~, Knapp, S.~~, Structural Genomics Consortium (SGC)~~	+	Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).,Heidenreich D, Moustakim M, Schmidt J, Merk D, Brennan PE, Fedorov O, Chaikuad A, Knapp S J Med Chem. 2018 Nov 26. doi: 10.1021/acs.jmedchem.8b01457. PMID:30407816<ref>PMID:30407816</ref>

-	~~Description: Crystal structure~~ of ~~ENL (MLLT1) in complex with acetyllysine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6hpz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
	[[Category: Chaikuad, A]]		[[Category: Chaikuad, A]]
		+	[[Category: Edwards, A M]]
	[[Category: Heidenreich, D]]		[[Category: Heidenreich, D]]
	[[Category: Knapp, S]]		[[Category: Knapp, S]]
-	[[Category: ~~Edwards, A.M~~]]	+	[[Category: Structural genomic]]
-	[[Category: ~~Arrowsmith, C.H~~]]	+	[[Category: Inhibitor complex]]
-	[[Category: ~~Structural Genomics Consortium (~~Sgc)]]	+	[[Category: Sgc]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Transcription]]
		+	[[Category: Yeats domain]]

OCA: Protected "6hpz" [edit=sysop:move=sysop]

OCA — Wed, 03 Oct 2018 06:14:05 GMT

Protected "6hpz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:14, 3 October 2018

OCA: New page: '''Unreleased structure''' The entry 6hpz is ON HOLD Authors: Heidenreich, D., Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC...

OCA — Wed, 03 Oct 2018 06:14:04 GMT

New page: '''Unreleased structure''' The entry 6hpz is ON HOLD Authors: Heidenreich, D., Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC...

New page

'''Unreleased structure'''

The entry 6hpz is ON HOLD

Authors: Heidenreich, D., Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal structure of ENL (MLLT1) in complex with acetyllysine
[[Category: Unreleased Structures]]
[[Category: Chaikuad, A]]
[[Category: Heidenreich, D]]
[[Category: Knapp, S]]
[[Category: Edwards, A.M]]
[[Category: Arrowsmith, C.H]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Bountra, C]]