6hww - Revision history

OCA at 01:33, 11 April 2020

OCA — Sat, 11 Apr 2020 01:33:32 GMT

←Older revision		Revision as of 01:33, 11 April 2020
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	<SX load='6hww' size='340' side='right' viewer='molstar' caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>		<SX load='6hww' size='340' side='right' viewer='molstar' caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mlv Mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6HWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mlv Mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6HWW FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11786 MLV])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11786 MLV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hww OCA], [http://pdbe.org/6hww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hww RCSB], [http://www.ebi.ac.uk/pdbsum/6hww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hww ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hww OCA], [http://pdbe.org/6hww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hww RCSB], [http://www.ebi.ac.uk/pdbsum/6hww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hww ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:57, 6 March 2020

OCA — Fri, 06 Mar 2020 21:57:32 GMT

←Older revision		Revision as of 21:57, 6 March 2020
Line 1:		Line 1:

	==Immature MLV capsid hexamer structure in intact virus particles==		==Immature MLV capsid hexamer structure in intact virus particles==
-	<~~StructureSection~~ load='6hww' size='340' side='right'caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>	+	<SX load='6hww' size='340' side='right' viewer='molstar' caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mlv Mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HWW FirstGlance]. <br>		<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mlv Mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HWW FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mlv]]		[[Category: Mlv]]

OCA at 08:17, 3 April 2019

OCA — Wed, 03 Apr 2019 08:17:12 GMT

←Older revision		Revision as of 08:17, 3 April 2019
Line 1:		Line 1:

	==Immature MLV capsid hexamer structure in intact virus particles==		==Immature MLV capsid hexamer structure in intact virus particles==
-	<StructureSection load='6hww' size='340' side='right' caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>	+	<StructureSection load='6hww' size='340' side='right'caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mlv Mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HWW FirstGlance]. <br>		<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mlv Mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HWW FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mlv]]		[[Category: Mlv]]
	[[Category: Briggs, J A.G]]		[[Category: Briggs, J A.G]]

OCA at 09:02, 19 December 2018

OCA — Wed, 19 Dec 2018 09:02:16 GMT

←Older revision		Revision as of 09:02, 19 December 2018
Line 3:		Line 3:
	<StructureSection load='6hww' size='340' side='right' caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>		<StructureSection load='6hww' size='340' side='right' caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mlv Mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HWW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hww OCA], [http://pdbe.org/6hww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hww RCSB], [http://www.ebi.ac.uk/pdbsum/6hww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hww ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11786 MLV])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hww OCA], [http://pdbe.org/6hww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hww RCSB], [http://www.ebi.ac.uk/pdbsum/6hww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hww ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Mlv]]
	[[Category: Briggs, J A.G]]		[[Category: Briggs, J A.G]]
	[[Category: Dolezal, M]]		[[Category: Dolezal, M]]
Line 30:		Line 32:
	[[Category: Capsid]]		[[Category: Capsid]]
	[[Category: Hexamer]]		[[Category: Hexamer]]
-	[[Category: Mlv]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 06:47, 5 December 2018

OCA — Wed, 05 Dec 2018 06:47:26 GMT

←Older revision		Revision as of 06:47, 5 December 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6hww is ~~ON HOLD~~	+	==Immature MLV capsid hexamer structure in intact virus particles==
		+	<StructureSection load='6hww' size='340' side='right' caption='[[6hww]], [[Resolution\|resolution]] 6.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hww]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HWW FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hww OCA], [http://pdbe.org/6hww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hww RCSB], [http://www.ebi.ac.uk/pdbsum/6hww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hww ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Retroviruses assemble and bud from infected cells in an immature form and require proteolytic maturation for infectivity. The CA (capsid) domains of the Gag polyproteins assemble a protein lattice as a truncated sphere in the immature virion. Proteolytic cleavage of Gag induces dramatic structural rearrangements; a subset of cleaved CA subsequently assembles into the mature core, whose architecture varies among retroviruses. Murine leukemia virus (MLV) is the prototypical gamma-retrovirus and serves as the basis of retroviral vectors, but the structure of the MLV CA layer is unknown. Here we have combined X-ray crystallography with cryoelectron tomography to determine the structures of immature and mature MLV CA layers within authentic viral particles. This reveals the structural changes associated with maturation, and, by comparison with HIV-1, uncovers conserved and variable features. In contrast to HIV-1, most MLV CA is used for assembly of the mature core, which adopts variable, multilayered morphologies and does not form a closed structure. Unlike in HIV-1, there is similarity between protein-protein interfaces in the immature MLV CA layer and those in the mature CA layer, and structural maturation of MLV could be achieved through domain rotations that largely maintain hexameric interactions. Nevertheless, the dramatic architectural change on maturation indicates that extensive disassembly and reassembly are required for mature core growth. The core morphology suggests that wrapping of the genome in CA sheets may be sufficient to protect the MLV ribonucleoprotein during cell entry.

-	~~Authors~~:	+	Structure and architecture of immature and mature murine leukemia virus capsids.,Qu K, Glass B, Dolezal M, Schur FKM, Murciano B, Rein A, Rumlova M, Ruml T, Krausslich HG, Briggs JAG Proc Natl Acad Sci U S A. 2018 Nov 26. pii: 1811580115. doi:, 10.1073/pnas.1811580115. PMID:30478053<ref>PMID:30478053</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6hww" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Briggs, J A.G]]
		+	[[Category: Dolezal, M]]
		+	[[Category: Glass, B]]
		+	[[Category: Kraeusslich, H G]]
		+	[[Category: Qu, K]]
		+	[[Category: Rein, A]]
		+	[[Category: Ruml, T]]
		+	[[Category: Rumlova, M]]
		+	[[Category: Schur, F K.M]]
		+	[[Category: Capsid]]
		+	[[Category: Hexamer]]
		+	[[Category: Mlv]]
		+	[[Category: Viral protein]]

OCA: Protected "6hww" [edit=sysop:move=sysop]

OCA — Wed, 24 Oct 2018 04:12:48 GMT

Protected "6hww" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:12, 24 October 2018

OCA: New page: '''Unreleased structure''' The entry 6hww is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Oct 2018 04:12:46 GMT

New page: '''Unreleased structure''' The entry 6hww is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6hww is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]