OCA at 08:24, 26 December 2018

OCA — Wed, 26 Dec 2018 08:24:12 GMT

←Older revision		Revision as of 08:24, 26 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6hx5 is ~~ON HOLD~~	+	==Selenols: a new class of Carbonic Anhydrase inhibitors==
		+	<StructureSection load='6hx5' size='340' side='right' caption='[[6hx5]], [[Resolution\|resolution]] 1.44Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hx5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HX5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GXE:benzeneselenol'>GXE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hx5 OCA], [http://pdbe.org/6hx5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hx5 RCSB], [http://www.ebi.ac.uk/pdbsum/6hx5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hx5 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.

-	~~Authors~~: Angeli, A., ~~Ferraroni~~, M.	+	Selenols: a new class of carbonic anhydrase inhibitors.,Angeli A, Tanini D, Nocentini A, Capperucci A, Ferraroni M, Gratteri P, Supuran CT Chem Commun (Camb). 2018 Dec 18. doi: 10.1039/c8cc08562e. PMID:30560259<ref>PMID:30560259</ref>

-	~~Description: Selenols:~~ a ~~new class~~ of ~~Carbonic Anhydrase inhibitors~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Ferraroni, M~~]]	+	<div class="pdbe-citations 6hx5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carbonate dehydratase]]
	[[Category: Angeli, A]]		[[Category: Angeli, A]]
		+	[[Category: Ferraroni, M]]
		+	[[Category: Carbonic anhydrase]]
		+	[[Category: Inhibitor]]
		+	[[Category: Protein binding]]

OCA: Protected "6hx5" [edit=sysop:move=sysop]

OCA — Wed, 24 Oct 2018 04:13:45 GMT

Protected "6hx5" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:13, 24 October 2018

OCA: New page: '''Unreleased structure''' The entry 6hx5 is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Selenols: a new class of Carbonic Anhydrase inhibitors [[Category: Unreleased Struc...

OCA — Wed, 24 Oct 2018 04:13:43 GMT

New page: '''Unreleased structure''' The entry 6hx5 is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Selenols: a new class of Carbonic Anhydrase inhibitors [[Category: Unreleased Struc...

New page

'''Unreleased structure'''

The entry 6hx5 is ON HOLD

Authors: Angeli, A., Ferraroni, M.

Description: Selenols: a new class of Carbonic Anhydrase inhibitors
[[Category: Unreleased Structures]]
[[Category: Ferraroni, M]]
[[Category: Angeli, A]]

6hx5 - Revision history

OCA at 08:24, 26 December 2018

OCA: Protected "6hx5" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6hx5 is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Selenols: a new class of Carbonic Anhydrase inhibitors [[Category: Unreleased Struc...