OCA at 15:25, 28 August 2019

OCA — Wed, 28 Aug 2019 15:25:51 GMT

←Older revision		Revision as of 15:25, 28 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~6hxw~~ is ~~ON HOLD~~	+	==structure of human CD73 in complex with antibody IPH53==
		+	<StructureSection load='6hxw' size='340' side='right'caption='[[6hxw]], [[Resolution\|resolution]] 2.78Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hxw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HXW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxw OCA], [http://pdbe.org/6hxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxw RCSB], [http://www.ebi.ac.uk/pdbsum/6hxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxw ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/5NTD_HUMAN 5NTD_HUMAN]] Hereditary arterial and articular multiple calcification syndrome. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/5NTD_HUMAN 5NTD_HUMAN]] Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.<ref>PMID:21933152</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Immune checkpoint inhibitors have revolutionized cancer treatment. However, many cancers are resistant to ICIs, and the targeting of additional inhibitory signals is crucial for limiting tumor evasion. The production of adenosine via the sequential activity of CD39 and CD73 ectoenzymes participates to the generation of an immunosuppressive tumor microenvironment. In order to disrupt the adenosine pathway, we generated two antibodies, IPH5201 and IPH5301, targeting human membrane-associated and soluble forms of CD39 and CD73, respectively, and efficiently blocking the hydrolysis of immunogenic ATP into immunosuppressive adenosine. These antibodies promoted antitumor immunity by stimulating dendritic cells and macrophages and by restoring the activation of T cells isolated from cancer patients. In a human CD39 knockin mouse preclinical model, IPH5201 increased the anti-tumor activity of the ATP-inducing chemotherapeutic drug oxaliplatin. These results support the use of anti-CD39 and anti-CD73 monoclonal antibodies and their combination with immune checkpoint inhibitors and chemotherapies in cancer.

-	~~Authors: Roussel~~, A., ~~Amigues~~, B.	+	Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.,Perrot I, Michaud HA, Giraudon-Paoli M, Augier S, Docquier A, Gros L, Courtois R, Dejou C, Jecko D, Becquart O, Rispaud-Blanc H, Gauthier L, Rossi B, Chanteux S, Gourdin N, Amigues B, Roussel A, Bensussan A, Eliaou JF, Bastid J, Romagne F, Morel Y, Narni-Mancinelli E, Vivier E, Paturel C, Bonnefoy N Cell Rep. 2019 May 21;27(8):2411-2425.e9. doi: 10.1016/j.celrep.2019.04.091. PMID:31116985<ref>PMID:31116985</ref>

-	~~Description: structure~~ of ~~human CD73 in complex with antibody IPH53~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Roussel, A~~]]	+	<div class="pdbe-citations 6hxw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 5'-nucleotidase]]
		+	[[Category: Large Structures]]
	[[Category: Amigues, B]]		[[Category: Amigues, B]]
		+	[[Category: Roussel, A]]
		+	[[Category: Immune system]]
		+	[[Category: Inhibitor antibody]]

OCA: Protected "6hxw" [edit=sysop:move=sysop]

OCA — Wed, 24 Oct 2018 04:17:00 GMT

Protected "6hxw" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:17, 24 October 2018

OCA: New page: '''Unreleased structure''' The entry 6hxw is ON HOLD Authors: Roussel, A., Amigues, B. Description: structure of human CD73 in complex with antibody IPH53 [[Category: Unreleased Struct...

OCA — Wed, 24 Oct 2018 04:16:58 GMT

New page: '''Unreleased structure''' The entry 6hxw is ON HOLD Authors: Roussel, A., Amigues, B. Description: structure of human CD73 in complex with antibody IPH53 [[Category: Unreleased Struct...

New page

'''Unreleased structure'''

The entry 6hxw is ON HOLD

Authors: Roussel, A., Amigues, B.

Description: structure of human CD73 in complex with antibody IPH53
[[Category: Unreleased Structures]]
[[Category: Roussel, A]]
[[Category: Amigues, B]]

6hxw - Revision history

OCA at 15:25, 28 August 2019

OCA: Protected "6hxw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6hxw is ON HOLD Authors: Roussel, A., Amigues, B. Description: structure of human CD73 in complex with antibody IPH53 [[Category: Unreleased Struct...