6i0p - Revision history

OCA at 11:43, 24 January 2024

OCA — Wed, 24 Jan 2024 11:43:51 GMT

←Older revision		Revision as of 11:43, 24 January 2024
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	<StructureSection load='6i0p' size='340' side='right'caption='[[6i0p]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6i0p' size='340' side='right'caption='[[6i0p]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i0p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thema Thema~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6I0P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i0p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I0P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=QAS:6-mercaptopyridine-2,3-dicarboxylic+acid'>QAS</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6i0k\|6i0k]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=QAS:6-mercaptopyridine-2,3-dicarboxylic+acid'>QAS</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadA, TM_1644 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0p OCA], [https://pdbe.org/6i0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i0p RCSB], [https://www.ebi.ac.uk/pdbsum/6i0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0p ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Quinolinate_synthase Quinolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.72 2.5.1.72] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6i0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0p OCA], [~~http~~://pdbe.org/6i0p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6i0p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6i0p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0p ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NADA_THEMA NADA_THEMA]] Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity).	+	[https://www.uniprot.org/uniprot/NADA_THEMA NADA_THEMA] Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Quinolinate synthase]]~~	+	[[Category: Thermotoga maritima MSB8]]
-	~~[[Category: Thema~~]]	+	[[Category: Fontecilla-Camps JC]]
-	[[Category: Fontecilla-Camps~~, J C~~]]	+	[[Category: Volbeda A]]
-	[[Category: Volbeda, A]]	+
-	~~[[Category: Iron sulfur cluster]]~~	+
-	~~[[Category: Nad biosynthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:18, 3 April 2019

OCA — Wed, 03 Apr 2019 08:18:07 GMT

←Older revision		Revision as of 08:18, 3 April 2019
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	<StructureSection load='6i0p' size='340' side='right'caption='[[6i0p]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6i0p' size='340' side='right'caption='[[6i0p]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i0p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I0P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i0p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I0P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=QAS:6-mercaptopyridine-2,3-dicarboxylic+acid'>QAS</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=QAS:6-mercaptopyridine-2,3-dicarboxylic+acid'>QAS</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6i0k\|6i0k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6i0k\|6i0k]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadA, TM_1644 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Quinolinate_synthase Quinolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.72 2.5.1.72] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Quinolinate_synthase Quinolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.72 2.5.1.72] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0p OCA], [http://pdbe.org/6i0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i0p RCSB], [http://www.ebi.ac.uk/pdbsum/6i0p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0p OCA], [http://pdbe.org/6i0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i0p RCSB], [http://www.ebi.ac.uk/pdbsum/6i0p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0p ProSAT]</span></td></tr>
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Quinolinate synthase]]		[[Category: Quinolinate synthase]]
		+	[[Category: Thema]]
	[[Category: Fontecilla-Camps, J C]]		[[Category: Fontecilla-Camps, J C]]
	[[Category: Volbeda, A]]		[[Category: Volbeda, A]]

OCA at 07:57, 20 March 2019

OCA — Wed, 20 Mar 2019 07:57:10 GMT

←Older revision		Revision as of 07:57, 20 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6i0p is ~~ON HOLD until Paper~~ Publication	+	==Structure of quinolinate synthase in complex with 6-mercaptopyridine-2,3-dicarboxylic acid==
		+	<StructureSection load='6i0p' size='340' side='right'caption='[[6i0p]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6i0p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I0P FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=QAS:6-mercaptopyridine-2,3-dicarboxylic+acid'>QAS</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6i0k\|6i0k]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Quinolinate_synthase Quinolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.72 2.5.1.72] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0p OCA], [http://pdbe.org/6i0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i0p RCSB], [http://www.ebi.ac.uk/pdbsum/6i0p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0p ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NADA_THEMA NADA_THEMA]] Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.

-	~~Authors~~:	+	Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.,Saez Cabodevilla J, Volbeda A, Hamelin O, Latour JM, Gigarel O, Clemancey M, Darnault C, Reichmann D, Amara P, Fontecilla-Camps JC, Ollagnier de Choudens S Chem Commun (Camb). 2019 Mar 11. doi: 10.1039/c8cc09023h. PMID:30855610<ref>PMID:30855610</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6i0p" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Quinolinate synthase]]
		+	[[Category: Fontecilla-Camps, J C]]
		+	[[Category: Volbeda, A]]
		+	[[Category: Iron sulfur cluster]]
		+	[[Category: Nad biosynthesis]]
		+	[[Category: Transferase]]

OCA at 06:00, 30 January 2019

OCA — Wed, 30 Jan 2019 06:00:21 GMT

←Older revision		Revision as of 06:00, 30 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6i0p is ON HOLD	+	The entry 6i0p is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6i0p" [edit=sysop:move=sysop]

OCA — Wed, 07 Nov 2018 10:34:13 GMT

Protected "6i0p" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:34, 7 November 2018

OCA: New page: '''Unreleased structure''' The entry 6i0p is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Nov 2018 10:34:12 GMT

New page: '''Unreleased structure''' The entry 6i0p is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6i0p is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]