6i48 - Revision history

OCA at 11:46, 24 January 2024

OCA — Wed, 24 Jan 2024 11:46:06 GMT

←Older revision		Revision as of 11:46, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6i48' size='340' side='right'caption='[[6i48]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6i48' size='340' side='right'caption='[[6i48]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i48]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Psea8 Psea8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I48 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6I48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i48]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_LESB58 Pseudomonas aeruginosa LESB58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I48 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H2H:(2~{R})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-pyrrolo[1,2-c]imidazol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide'>H2H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.196Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxC, PLES_47851 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=557722 PSEA8])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H2H:(2~{R})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-pyrrolo[1,2-c]imidazol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide'>H2H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-acyl-N-acetylglucosamine_deacetylase UDP-3-O-acyl-N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.108 3.5.1.108] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i48 OCA], [https://pdbe.org/6i48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i48 RCSB], [https://www.ebi.ac.uk/pdbsum/6i48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i48 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6i48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i48 OCA], [~~http~~://pdbe.org/6i48 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6i48 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6i48 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6i48 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LPXC_PSEA8 LPXC_PSEA8]] Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.	+	[https://www.uniprot.org/uniprot/LPXC_PSEA8 LPXC_PSEA8] Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6i48" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6i48" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Psea8]]~~	+	[[Category: Pseudomonas aeruginosa LESB58]]
-	~~[[Category: UDP-3-O-acyl-N-acetylglucosamine deacetylase~~]]	+	[[Category: Blumstein A-C]]
-	[[Category: Blumstein, A C]]	+	[[Category: Bur D]]
-	[[Category: Bur, D]]	+	[[Category: Diethelm S]]
-	[[Category: Diethelm, S]]	+	[[Category: Enderlin-Paput M]]
-	[[Category: Enderlin-Paput, M]]	+	[[Category: Gauvin J-C]]
-	[[Category: Gauvin, J C]]	+	[[Category: Gnerre C]]
-	[[Category: Gnerre, C]]	+	[[Category: Hermann C]]
-	[[Category: Hermann, C]]	+	[[Category: Hubschwerlen C]]
-	[[Category: Hubschwerlen, C]]	+	[[Category: Jacob L]]
-	[[Category: Jacob, L]]	+	[[Category: Lange R]]
-	[[Category: Lange, R]]	+	[[Category: Locher HH]]
-	[[Category: Locher~~, H H~~]]	+	[[Category: Mac Sweeney A]]
-	[[Category: Masse, F]]	+	[[Category: Masse F]]
-	[[Category: Mathieu, G]]	+	[[Category: Mathieu G]]
-	[[Category: Mirre, A]]	+	[[Category: Mirre A]]
-	[[Category: Panchaud, P]]	+	[[Category: Panchaud P]]
-	[[Category: Ritz, D]]	+	[[Category: Ritz D]]
-	[[Category: Rueedi, G]]	+	[[Category: Rueedi G]]
-	[[Category: Schmitt, C]]	+	[[Category: Schmitt C]]
-	[[Category: Seeland, S]]	+	[[Category: Seeland S]]
-	[[Category: Seiler, P]]	+	[[Category: Seiler P]]
-	[[Category: Specklin, J L]]	+	[[Category: Specklin J-L]]
-	[[Category: Surivet, J P]]	+	[[Category: Surivet J-P]]
-	~~[[Category: Sweeney, A Mac~~]]	+	[[Category: Tidten-Luksch N]]
-	[[Category: Tidten-Luksch, N]]	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 16:32, 22 January 2020

OCA — Wed, 22 Jan 2020 16:32:46 GMT

←Older revision		Revision as of 16:32, 22 January 2020
Line 3:		Line 3:
	<StructureSection load='6i48' size='340' side='right'caption='[[6i48]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6i48' size='340' side='right'caption='[[6i48]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i48]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i48]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Psea8 Psea8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I48 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H2H:(2~{R})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-pyrrolo[1,2-c]imidazol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide'>H2H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H2H:(2~{R})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-pyrrolo[1,2-c]imidazol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide'>H2H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxC, PLES_47851 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=557722 PSEA8])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-acyl-N-acetylglucosamine_deacetylase UDP-3-O-acyl-N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.108 3.5.1.108] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-acyl-N-acetylglucosamine_deacetylase UDP-3-O-acyl-N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.108 3.5.1.108] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i48 OCA], [http://pdbe.org/6i48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i48 RCSB], [http://www.ebi.ac.uk/pdbsum/6i48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i48 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i48 OCA], [http://pdbe.org/6i48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i48 RCSB], [http://www.ebi.ac.uk/pdbsum/6i48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i48 ProSAT]</span></td></tr>
Line 24:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Psea8]]
	[[Category: UDP-3-O-acyl-N-acetylglucosamine deacetylase]]		[[Category: UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
	[[Category: Blumstein, A C]]		[[Category: Blumstein, A C]]

OCA at 07:37, 18 December 2019

OCA — Wed, 18 Dec 2019 07:37:58 GMT

←Older revision		Revision as of 07:37, 18 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6i48 is ~~ON HOLD until Paper~~ Publication	+	==Structure of P. aeruginosa LpxC with compound 12: (2R)-4-(6-(2-Fluoro-4-methoxyphenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide==
		+	<StructureSection load='6i48' size='340' side='right'caption='[[6i48]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6i48]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I48 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H2H:(2~{R})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-pyrrolo[1,2-c]imidazol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide'>H2H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-acyl-N-acetylglucosamine_deacetylase UDP-3-O-acyl-N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.108 3.5.1.108] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i48 OCA], [http://pdbe.org/6i48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i48 RCSB], [http://www.ebi.ac.uk/pdbsum/6i48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i48 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LPXC_PSEA8 LPXC_PSEA8]] Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	UDP-3-O-((R)-3-hydroxymyristoyl)-N-glucosamine deacetylase (LpxC) is as an attractive target for the discovery and development of novel antibacterial drugs to address the critical medical need created by multi-drug resistant Gram-negative bacteria. Using a scaffold hopping approach on a known family of methylsulfone hydroxamate LpxC inhibitors, several hit series eliciting potent antibacterial activities against Enterobacteriaceae and Pseudomonas aeruginosa were identified. Subsequent hit-to-lead optimization, using co-crystal structures of inhibitors bound to Pseudomonas aeruginosa LpxC as guides, resulted in the discovery of multiple chemical series based on i) isoindolin-1-ones, ii) 4,5-dihydro-6H-thieno[2,3-c]pyrrol-6-ones and iii) 1,2-dihydro-3H-pyrrolo[1,2-c]imidazole-3-ones. Synthetic methods, antibacterial activities and relative binding affinities, as well as physico-chemical properties that allowed compound prioritization are presented. Finally, in vivo properties of lead molecules which belong to the most promising pyrrolo-imidazolone series such as 18d, are discussed.

-	~~Authors: Surivet, J.~~-P., Panchaud, P., Specklin~~, J.-L.~~, Diethelm, S., Blumstein~~, A.-C.~~, Gauvin~~, J.-C.~~, Jacob, L., Masse, F., Mathieu, G., Mirre, A., Schmitt, C~~., Enderlin-Paput, M.~~, Lange, R~~., Bur, D.~~, Tidten-Luksch, N., Gnerre, C., Seeland, S~~., Hermann~~, C~~., Locher, H.H.~~, Seiler, P., Mac Sweeney, A., Hubschwerlen, C., Ritz, D., Rueedi, G.	+	Discovery of Novel Inhibitors of LpxC Displaying Potent In Vitro Activity against Gram-Negative Bacteria.,Surivet JP, Panchaud P, Specklin JL, Diethelm S, Blumstein AC, Gauvin JC, Jacob L, Masse F, Mathieu G, Mirre A, Schmitt C, Lange R, Tidten-Luksch N, Gnerre C, Seeland S, Herrmann C, Seiler P, Enderlin-Paput M, Mac Sweeney A, Wicki M, Hubschwerlen C, Ritz D, Rueedi G J Med Chem. 2019 Dec 5. doi: 10.1021/acs.jmedchem.9b01604. PMID:31804826<ref>PMID:31804826</ref>

-	~~Description: Structure~~ of P. ~~aeruginosa LpxC with compound 12: (2R)-4-(6-(2-Fluoro-4-methoxyphenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Gauvin, J.~~-~~C]]~~	+	<div class="pdbe-citations 6i48" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Hubschwerlen, C]]~~	+	== References ==
-	~~[[Category: Specklin, J.-L]]~~	+	<references/>
-	~~[[Category: Jacob, L]]~~	+	__TOC__
-	~~[[Category: Schmitt, C]]~~	+	</StructureSection>
-	~~[[Category: Rueedi, G]]~~	+	[[Category: Large Structures]]
-	[[Category: ~~Hermann, C~~]]	+	[[Category: UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
-	[[Category: ~~Enderlin~~-~~Paput, M~~]]	+	[[Category: Blumstein, A C]]
-	[[Category: ~~Surivet~~, ~~J.-P~~]]	+
	[[Category: Bur, D]]		[[Category: Bur, D]]
-	[[Category: Mirre, A]]
	[[Category: Diethelm, S]]		[[Category: Diethelm, S]]
-	[[Category: ~~Seiler~~, P]]	+	[[Category: Enderlin-Paput, M]]
-	[[Category: ~~Tidten-Luksch~~, N]]	+	[[Category: Gauvin, J C]]
-	[[Category: ~~Mac Sweeney~~, A]]	+	[[Category: Gnerre, C]]
-	[[Category: ~~Seeland~~, S]]	+	[[Category: Hermann, C]]
		+	[[Category: Hubschwerlen, C]]
		+	[[Category: Jacob, L]]
	[[Category: Lange, R]]		[[Category: Lange, R]]
-	~~[[Category: Ritz, D]]~~	+	[[Category: Locher, H H]]
-	~~[[Category: Mathieu, G]]~~	+
-	[[Category: Locher, H.H]]	+
	[[Category: Masse, F]]		[[Category: Masse, F]]
-	[[Category: ~~Blumstein~~, ~~A.-C~~]]	+	[[Category: Mathieu, G]]
-	[[Category: ~~Gnerre~~, C]]	+	[[Category: Mirre, A]]
	[[Category: Panchaud, P]]		[[Category: Panchaud, P]]
		+	[[Category: Ritz, D]]
		+	[[Category: Rueedi, G]]
		+	[[Category: Schmitt, C]]
		+	[[Category: Seeland, S]]
		+	[[Category: Seiler, P]]
		+	[[Category: Specklin, J L]]
		+	[[Category: Surivet, J P]]
		+	[[Category: Sweeney, A Mac]]
		+	[[Category: Tidten-Luksch, N]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]

OCA at 18:32, 2 December 2018

OCA — Sun, 02 Dec 2018 18:32:08 GMT

←Older revision		Revision as of 18:32, 2 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6i48 is ON HOLD	+	The entry 6i48 is ON HOLD until Paper Publication

	Authors: Surivet, J.-P., Panchaud, P., Specklin, J.-L., Diethelm, S., Blumstein, A.-C., Gauvin, J.-C., Jacob, L., Masse, F., Mathieu, G., Mirre, A., Schmitt, C., Enderlin-Paput, M., Lange, R., Bur, D., Tidten-Luksch, N., Gnerre, C., Seeland, S., Hermann, C., Locher, H.H., Seiler, P., Mac Sweeney, A., Hubschwerlen, C., Ritz, D., Rueedi, G.		Authors: Surivet, J.-P., Panchaud, P., Specklin, J.-L., Diethelm, S., Blumstein, A.-C., Gauvin, J.-C., Jacob, L., Masse, F., Mathieu, G., Mirre, A., Schmitt, C., Enderlin-Paput, M., Lange, R., Bur, D., Tidten-Luksch, N., Gnerre, C., Seeland, S., Hermann, C., Locher, H.H., Seiler, P., Mac Sweeney, A., Hubschwerlen, C., Ritz, D., Rueedi, G.

OCA: Protected "6i48" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2018 06:25:11 GMT

Protected "6i48" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:25, 14 November 2018

OCA: New page: '''Unreleased structure''' The entry 6i48 is ON HOLD Authors: Surivet, J.-P., Panchaud, P., Specklin, J.-L., Diethelm, S., Blumstein, A.-C., Gauvin, J.-C., Jacob, L., Masse, F., Mathieu...

OCA — Wed, 14 Nov 2018 06:25:10 GMT

New page: '''Unreleased structure''' The entry 6i48 is ON HOLD Authors: Surivet, J.-P., Panchaud, P., Specklin, J.-L., Diethelm, S., Blumstein, A.-C., Gauvin, J.-C., Jacob, L., Masse, F., Mathieu...

New page

'''Unreleased structure'''

The entry 6i48 is ON HOLD

Authors: Surivet, J.-P., Panchaud, P., Specklin, J.-L., Diethelm, S., Blumstein, A.-C., Gauvin, J.-C., Jacob, L., Masse, F., Mathieu, G., Mirre, A., Schmitt, C., Enderlin-Paput, M., Lange, R., Bur, D., Tidten-Luksch, N., Gnerre, C., Seeland, S., Hermann, C., Locher, H.H., Seiler, P., Mac Sweeney, A., Hubschwerlen, C., Ritz, D., Rueedi, G.

Description: Structure of P. aeruginosa LpxC with compound 12: (2R)-4-(6-(2-Fluoro-4-methoxyphenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
[[Category: Unreleased Structures]]
[[Category: Gauvin, J.-C]]
[[Category: Hubschwerlen, C]]
[[Category: Specklin, J.-L]]
[[Category: Jacob, L]]
[[Category: Schmitt, C]]
[[Category: Rueedi, G]]
[[Category: Hermann, C]]
[[Category: Enderlin-Paput, M]]
[[Category: Surivet, J.-P]]
[[Category: Bur, D]]
[[Category: Mirre, A]]
[[Category: Diethelm, S]]
[[Category: Seiler, P]]
[[Category: Tidten-Luksch, N]]
[[Category: Mac Sweeney, A]]
[[Category: Seeland, S]]
[[Category: Lange, R]]
[[Category: Ritz, D]]
[[Category: Mathieu, G]]
[[Category: Locher, H.H]]
[[Category: Masse, F]]
[[Category: Blumstein, A.-C]]
[[Category: Gnerre, C]]
[[Category: Panchaud, P]]