6i50 - Revision history

OCA at 11:47, 24 January 2024

OCA — Wed, 24 Jan 2024 11:47:08 GMT

←Older revision		Revision as of 11:47, 24 January 2024
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	<StructureSection load='6i50' size='340' side='right'caption='[[6i50]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='6i50' size='340' side='right'caption='[[6i50]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i50]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I50 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6I50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I50 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6i50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i50 OCA], [~~http~~://pdbe.org/6i50 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6i50 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6i50 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6i50 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.69Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i50 OCA], [https://pdbe.org/6i50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i50 RCSB], [https://www.ebi.ac.uk/pdbsum/6i50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i50 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2H1VTZ0_SPOFR A0A2H1VTZ0_SPOFR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Spodoptera frugiperda]]		[[Category: Spodoptera frugiperda]]
-	[[Category: Bertinelli, M]]	+	[[Category: Bertinelli M]]
-	[[Category: Grimes~~, J M~~]]	+	[[Category: Grimes JM]]
-	[[Category: Paesen~~, G C~~]]	+	[[Category: Paesen GC]]
-	[[Category: Renner, M]]	+	[[Category: Renner M]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Arthropod]]~~	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Tnf]]~~	+
-	~~[[Category: Tumour necrosis factor~~]]	+

OCA at 15:55, 28 August 2019

OCA — Wed, 28 Aug 2019 15:55:09 GMT

←Older revision		Revision as of 15:55, 28 August 2019
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i50 OCA], [http://pdbe.org/6i50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i50 RCSB], [http://www.ebi.ac.uk/pdbsum/6i50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i50 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i50 OCA], [http://pdbe.org/6i50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i50 RCSB], [http://www.ebi.ac.uk/pdbsum/6i50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i50 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The tumour necrosis factor alpha (TNFalpha) superfamily of proteins are critical in numerous biological processes, such as in development and immunity. Eiger is the sole TNFalpha member described in arthropods such as in the important model organism Drosophila. To date there are no structural data on any Eiger protein. Here we present the structure of the TNF domain of Eiger from the fall armyworm Spodoptera frugiperda (SfEiger) to 1.7 A from a serendipitously obtained crystal without prior knowledge of the protein sequence. Our structure confirms that canonical trimerization is conserved from ancestral TNFs and points towards a mode of receptor engagement. Furthermore, we observe numerous surface histidines on SfEiger, potentially acting as pH switches following internalization into endosomes. Our data contributes to the genome annotation of S. frugiperda, a voracious agricultural pest, and can serve as a basis for future structure-function investigations of the TNF system in related arthropods such as Drosophila.
		+
		+	High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes.,Bertinelli M, Paesen GC, Grimes JM, Renner M Commun Biol. 2019 Aug 6;2:293. doi: 10.1038/s42003-019-0541-0. eCollection 2019. PMID:31396573<ref>PMID:31396573</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6i50" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:31, 14 August 2019

OCA — Wed, 14 Aug 2019 16:31:10 GMT

←Older revision		Revision as of 16:31, 14 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6i50 is ~~ON HOLD~~	+	==Structure of Eiger TNF from S. frugiperda==
-		+	<StructureSection load='6i50' size='340' side='right'caption='[[6i50]], [[Resolution\|resolution]] 1.69Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6i50]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I50 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i50 OCA], [http://pdbe.org/6i50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i50 RCSB], [http://www.ebi.ac.uk/pdbsum/6i50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i50 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Spodoptera frugiperda]]
		+	[[Category: Bertinelli, M]]
		+	[[Category: Grimes, J M]]
		+	[[Category: Paesen, G C]]
		+	[[Category: Renner, M]]
		+	[[Category: Apoptosis]]
		+	[[Category: Arthropod]]
		+	[[Category: Cytokine]]
		+	[[Category: Tnf]]
		+	[[Category: Tumour necrosis factor]]

OCA: Protected "6i50" [edit=sysop:move=sysop]

OCA — Sun, 02 Dec 2018 18:34:05 GMT

Protected "6i50" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:34, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6i50 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Sun, 02 Dec 2018 18:34:04 GMT

New page: '''Unreleased structure''' The entry 6i50 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6i50 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]