6i7e - Revision history

OCA at 11:48, 24 January 2024

OCA — Wed, 24 Jan 2024 11:48:29 GMT

←Older revision		Revision as of 11:48, 24 January 2024
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	<StructureSection load='6i7e' size='340' side='right'caption='[[6i7e]], [[Resolution\|resolution]] 3.49Å' scene=''>		<StructureSection load='6i7e' size='340' side='right'caption='[[6i7e]], [[Resolution\|resolution]] 3.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i7e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I7E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6I7E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I7E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=~~VO4~~:~~VANADATE+ION~~'>~~VO4~~</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.492Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~SEP~~:~~PHOSPHOSERINE~~'>~~SEP~~</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6i7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i7e OCA], [~~http~~://pdbe.org/6i7e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6i7e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6i7e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6i7e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i7e OCA], [https://pdbe.org/6i7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i7e RCSB], [https://www.ebi.ac.uk/pdbsum/6i7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i7e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYOA_PLAF7 MYOA_PLAF7]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).	+	[https://www.uniprot.org/uniprot/MYOA_PLAF7 MYOA_PLAF7] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6i7e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6i7e" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Auguin, D]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Baum, J]]	+	[[Category: Auguin D]]
-	[[Category: Houdusse, A]]	+	[[Category: Baum J]]
-	[[Category: Jousset, G]]	+	[[Category: Houdusse A]]
-	[[Category: Moussaoui, D]]	+	[[Category: Jousset G]]
-	[[Category: Robert-Paganin, J]]	+	[[Category: Moussaoui D]]
-	[[Category: Trybus~~, K M]]~~	+	[[Category: Robert-Paganin J]]
-	~~[[Category: Motor protein]]~~	+	[[Category: Trybus KM]]
-	~~[[Category: Myosin some]]~~	+
-	~~[[Category: Plasmodium falciparum]]~~	+
-	~~[[Category: Tunable mechanism~~]]	+

OCA at 05:49, 7 August 2019

OCA — Wed, 07 Aug 2019 05:49:20 GMT

←Older revision		Revision as of 05:49, 7 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6i7e is ~~ON HOLD~~	+	==Plasmodium falciparum Myosin A, Pre-powerstroke==
		+	<StructureSection load='6i7e' size='340' side='right'caption='[[6i7e]], [[Resolution\|resolution]] 3.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6i7e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I7E FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i7e OCA], [http://pdbe.org/6i7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i7e RCSB], [http://www.ebi.ac.uk/pdbsum/6i7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i7e ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYOA_PLAF7 MYOA_PLAF7]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium parasites are obligate intracellular protozoa and causative agents of malaria, responsible for half a million deaths each year. The lifecycle progression of the parasite is reliant on cell motility, a process driven by myosin A, an unconventional single-headed class XIV molecular motor. Here we demonstrate that myosin A from Plasmodium falciparum (PfMyoA) is critical for red blood cell invasion. Further, using a combination of X-ray crystallography, kinetics, and in vitro motility assays, we elucidate the non-canonical interactions that drive this motor's function. We show that PfMyoA motor properties are tuned by heavy chain phosphorylation (Ser19), with unphosphorylated PfMyoA exhibiting enhanced ensemble force generation at the expense of speed. Regulated phosphorylation may therefore optimize PfMyoA for enhanced force generation during parasite invasion or for fast motility during dissemination. The three PfMyoA crystallographic structures presented here provide a blueprint for discovery of specific inhibitors designed to prevent parasite infection.

-	~~Authors:~~ Robert-Paganin, J., ~~Auguin~~, D., ~~Moussaoui~~, D., ~~Jousset~~, G., Baum, J., Trybus~~, K.M.~~, Houdusse, A.	+	Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism.,Robert-Paganin J, Robblee JP, Auguin D, Blake TCA, Bookwalter CS, Krementsova EB, Moussaoui D, Previs MJ, Jousset G, Baum J, Trybus KM, Houdusse A Nat Commun. 2019 Jul 23;10(1):3286. doi: 10.1038/s41467-019-11120-0. PMID:31337750<ref>PMID:31337750</ref>

-	~~Description: Plasmodium falciparum Myosin A~~, ~~Pre~~-~~powerstroke~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6i7e" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Auguin, D]]		[[Category: Auguin, D]]
-	[[Category: Trybus, K.M]]
-	[[Category: Moussaoui, D]]
-	[[Category: Houdusse, A]]
-	[[Category: Robert-Paganin, J]]
	[[Category: Baum, J]]		[[Category: Baum, J]]
		+	[[Category: Houdusse, A]]
	[[Category: Jousset, G]]		[[Category: Jousset, G]]
		+	[[Category: Moussaoui, D]]
		+	[[Category: Robert-Paganin, J]]
		+	[[Category: Trybus, K M]]
		+	[[Category: Motor protein]]
		+	[[Category: Myosin some]]
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Tunable mechanism]]

OCA: Protected "6i7e" [edit=sysop:move=sysop]

OCA — Sun, 02 Dec 2018 18:41:27 GMT

Protected "6i7e" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:41, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6i7e is ON HOLD Authors: Robert-Paganin, J., Auguin, D., Moussaoui, D., Jousset, G., Baum, J., Trybus, K.M., Houdusse, A. Description: Plasmodium f...

OCA — Sun, 02 Dec 2018 18:41:26 GMT

New page: '''Unreleased structure''' The entry 6i7e is ON HOLD Authors: Robert-Paganin, J., Auguin, D., Moussaoui, D., Jousset, G., Baum, J., Trybus, K.M., Houdusse, A. Description: Plasmodium f...

New page

'''Unreleased structure'''

The entry 6i7e is ON HOLD

Authors: Robert-Paganin, J., Auguin, D., Moussaoui, D., Jousset, G., Baum, J., Trybus, K.M., Houdusse, A.

Description: Plasmodium falciparum Myosin A, Pre-powerstroke
[[Category: Unreleased Structures]]
[[Category: Auguin, D]]
[[Category: Trybus, K.M]]
[[Category: Moussaoui, D]]
[[Category: Houdusse, A]]
[[Category: Robert-Paganin, J]]
[[Category: Baum, J]]
[[Category: Jousset, G]]