6i99 - Revision history

OCA at 11:49, 24 January 2024

OCA — Wed, 24 Jan 2024 11:49:45 GMT

←Older revision		Revision as of 11:49, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6i99' size='340' side='right'caption='[[6i99]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6i99' size='340' side='right'caption='[[6i99]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i99]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I99 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6I99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i99]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I99 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=H88:~{N}~~-[~~2-methyl-5-~~[~~8-[4-(methylsulfonylamino)phenyl~~]-2~~-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide'>H88</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.001Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>BMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H88:~{N}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide'>H88</scene></td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Non~~-~~specific_protein~~-~~tyrosine_kinase Non~~-~~specific protein~~-~~tyrosine kinase], with EC number~~ [~~http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.~~2] </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i99 OCA], [https://pdbe.org/6i99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i99 RCSB], [https://www.ebi.ac.uk/pdbsum/6i99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i99 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6i99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i99 OCA], [~~http~~://pdbe.org/6i99 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6i99 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6i99 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6i99 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BMX_HUMAN BMX_HUMAN]] Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.<ref>PMID:9520419</ref> <ref>PMID:10688651</ref> <ref>PMID:11331870</ref> <ref>PMID:12370298</ref> <ref>PMID:12832404</ref> <ref>PMID:15788485</ref> <ref>PMID:18292575</ref>	+	[https://www.uniprot.org/uniprot/BMX_HUMAN BMX_HUMAN] Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.<ref>PMID:9520419</ref> <ref>PMID:10688651</ref> <ref>PMID:11331870</ref> <ref>PMID:12370298</ref> <ref>PMID:12832404</ref> <ref>PMID:15788485</ref> <ref>PMID:18292575</ref>
		+
		+	==See Also==
		+	*[[Tyrosine kinase 3D structures\|Tyrosine kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific protein-tyrosine kinase]]~~	+	[[Category: Bernardes GJL]]
-	[[Category: Bernardes~~, G J.L~~]]	+	[[Category: Marques MC]]
-	[[Category: Marques~~, M C~~]]	+	[[Category: Matias PM]]
-	[[Category: Matias~~, P M~~]]	+	[[Category: Seixas JD]]
-	[[Category: Seixas~~, J D~~]]	+	[[Category: Sousa BB]]
-	[[Category: Sousa~~, B B]]~~	+
-	~~[[Category: Cytoplasmic tyrosine-kinase bmx]]~~	+
-	~~[[Category: Cytosolic protein]]~~	+
-	~~[[Category: Homo sapien~~]]	+

OCA at 07:29, 4 November 2020

OCA — Wed, 04 Nov 2020 07:29:23 GMT

←Older revision		Revision as of 07:29, 4 November 2020
Line 1:		Line 1:

	==Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24==		==Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24==
-	<StructureSection load='6i99' size='340' side='right'caption='[[6i99]]' scene=''>	+	<StructureSection load='6i99' size='340' side='right'caption='[[6i99]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I99 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6I99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i99]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I99 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6I99 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6i99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i99 OCA], [http://pdbe.org/6i99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i99 RCSB], [http://www.ebi.ac.uk/pdbsum/6i99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i99 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H88:~{N}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide'>H88</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6i99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i99 OCA], [http://pdbe.org/6i99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i99 RCSB], [http://www.ebi.ac.uk/pdbsum/6i99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i99 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BMX_HUMAN BMX_HUMAN]] Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.<ref>PMID:9520419</ref> <ref>PMID:10688651</ref> <ref>PMID:11331870</ref> <ref>PMID:12370298</ref> <ref>PMID:12832404</ref> <ref>PMID:15788485</ref> <ref>PMID:18292575</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bernardes ~~GJL~~]]	+	[[Category: Non-specific protein-tyrosine kinase]]
-	[[Category: Marques MC]]	+	[[Category: Bernardes, G J.L]]
-	[[Category: Matias PM]]	+	[[Category: Marques, M C]]
-	[[Category: Seixas JD]]	+	[[Category: Matias, P M]]
-	[[Category: Sousa BB]]	+	[[Category: Seixas, J D]]
		+	[[Category: Sousa, B B]]
		+	[[Category: Cytoplasmic tyrosine-kinase bmx]]
		+	[[Category: Cytosolic protein]]
		+	[[Category: Homo sapien]]

OCA at 06:51, 27 May 2020

OCA — Wed, 27 May 2020 06:51:43 GMT

←Older revision		Revision as of 06:51, 27 May 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6i99 ~~is ON HOLD until Paper Publication~~	+	==Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24==
-		+	<StructureSection load='6i99' size='340' side='right'caption='[[6i99]]' scene=''>
-	~~Authors~~: ~~Sousa, B~~.B.~~, Matias, P~~.M., ~~Marques, M~~.C., ~~Seixas~~, J.D., ~~Bernardes, G~~.J.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I99 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6I99 FirstGlance]. <br>
-	~~Description: Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6i99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i99 OCA], [http://pdbe.org/6i99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i99 RCSB], [http://www.ebi.ac.uk/pdbsum/6i99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i99 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Marques, M.C~~]]	+	__TOC__
-	[[Category: ~~Sousa, B.B~~]]	+	</StructureSection>
-	[[Category: ~~Bernardes, G.J.L~~]]	+	[[Category: Large Structures]]
-	[[Category: Seixas~~, J.D~~]]	+	[[Category: Bernardes GJL]]
-	[[Category: ~~Matias, P.M~~]]	+	[[Category: Marques MC]]
		+	[[Category: Matias PM]]
		+	[[Category: Seixas JD]]
		+	[[Category: Sousa BB]]

OCA at 05:04, 12 December 2018

OCA — Wed, 12 Dec 2018 05:04:25 GMT

←Older revision		Revision as of 05:04, 12 December 2018
Line 3:		Line 3:
	The entry 6i99 is ON HOLD until Paper Publication		The entry 6i99 is ON HOLD until Paper Publication

-	Authors: Sousa, B.B., Matias, P.M., Marques, M.C., Seixas, J.D., Bernardes, J.L.	+	Authors: Sousa, B.B., Matias, P.M., Marques, M.C., Seixas, J.D., Bernardes, G.J.L.

	Description: Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24		Description: Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Marques, M.C]]		[[Category: Marques, M.C]]
-	[[Category: Bernardes, J.L]]
	[[Category: Sousa, B.B]]		[[Category: Sousa, B.B]]
		+	[[Category: Bernardes, G.J.L]]
	[[Category: Seixas, J.D]]		[[Category: Seixas, J.D]]
	[[Category: Matias, P.M]]		[[Category: Matias, P.M]]

OCA at 04:58, 5 December 2018

OCA — Wed, 05 Dec 2018 04:58:51 GMT

←Older revision		Revision as of 04:58, 5 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6i99 is ON HOLD	+	The entry 6i99 is ON HOLD until Paper Publication

	Authors: Sousa, B.B., Matias, P.M., Marques, M.C., Seixas, J.D., Bernardes, J.L.		Authors: Sousa, B.B., Matias, P.M., Marques, M.C., Seixas, J.D., Bernardes, J.L.

OCA: Protected "6i99" [edit=sysop:move=sysop]

OCA — Sun, 02 Dec 2018 18:46:57 GMT

Protected "6i99" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:46, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6i99 is ON HOLD Authors: Sousa, B.B., Matias, P.M., Marques, M.C., Seixas, J.D., Bernardes, J.L. Description: Bone Marrow Tyrosine Kinase in Chromo...

OCA — Sun, 02 Dec 2018 18:46:55 GMT

New page: '''Unreleased structure''' The entry 6i99 is ON HOLD Authors: Sousa, B.B., Matias, P.M., Marques, M.C., Seixas, J.D., Bernardes, J.L. Description: Bone Marrow Tyrosine Kinase in Chromo...

New page

'''Unreleased structure'''

The entry 6i99 is ON HOLD

Authors: Sousa, B.B., Matias, P.M., Marques, M.C., Seixas, J.D., Bernardes, J.L.

Description: Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24
[[Category: Unreleased Structures]]
[[Category: Marques, M.C]]
[[Category: Bernardes, J.L]]
[[Category: Sousa, B.B]]
[[Category: Seixas, J.D]]
[[Category: Matias, P.M]]