6ib7 - Revision history

OCA at 11:50, 24 January 2024

OCA — Wed, 24 Jan 2024 11:50:48 GMT

←Older revision		Revision as of 11:50, 24 January 2024
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	<StructureSection load='6ib7' size='340' side='right'caption='[[6ib7]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='6ib7' size='340' side='right'caption='[[6ib7]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ib7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IB7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6IB7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ib7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IB7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.245Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>suhB, ssyA, b2533, JW2517 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ib7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ib7 OCA], [https://pdbe.org/6ib7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ib7 RCSB], [https://www.ebi.ac.uk/pdbsum/6ib7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ib7 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ib7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ib7 OCA], [~~http~~://pdbe.org/6ib7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ib7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ib7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ib7 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SUHB_ECOLI SUHB_ECOLI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Inositol-phosphate phosphatase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang~~, Y H~~]]	+	[[Category: Huang YH]]
-	[[Category: Loll, B]]	+	[[Category: Loll B]]
-	[[Category: Wahl~~, M C]]~~	+	[[Category: Wahl MC]]
-	~~[[Category: Antitermiantion]]~~	+
-	~~[[Category: Suhb]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 06:56, 29 April 2020

OCA — Wed, 29 Apr 2020 06:56:37 GMT

←Older revision		Revision as of 06:56, 29 April 2020
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	<StructureSection load='6ib7' size='340' side='right'caption='[[6ib7]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='6ib7' size='340' side='right'caption='[[6ib7]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ib7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IB7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IB7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ib7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IB7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IB7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">suhB, ssyA, b2533, JW2517 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ib7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ib7 OCA], [http://pdbe.org/6ib7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ib7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ib7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ib7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ib7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ib7 OCA], [http://pdbe.org/6ib7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ib7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ib7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ib7 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ribosomal RNA synthesis in Escherichia coli involves a transcription complex, in which RNA polymerase is modified by a signal element on the transcript, Nus factors A, B, E and G, ribosomal protein S4 and inositol mono-phosphatase SuhB. This complex is resistant to rho-dependent termination and facilitates ribosomal RNA folding, maturation and subunit assembly. The functional contributions of SuhB and their structural bases are presently unclear. We show that SuhB directly binds the RNA signal element and the C-terminal AR2 domain of NusA, and we delineate the atomic basis of the latter interaction by macromolecular crystallography. SuhB recruitment to a ribosomal RNA transcription complex depends on the RNA signal element but not on the NusA AR2 domain. SuhB in turn is required for stable integration of the NusB/E dimer into the complex. In vitro transcription assays revealed that SuhB is crucial for delaying or suppressing rho-dependent termination, that SuhB also can reduce intrinsic termination, and that SuhB-AR2 contacts contribute to these effects. Together, our results reveal functions of SuhB during ribosomal RNA synthesis and delineate some of the underlying molecular interactions.
		+
		+	Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis.,Huang YH, Said N, Loll B, Wahl MC Nucleic Acids Res. 2019 Jul 9;47(12):6488-6503. doi: 10.1093/nar/gkz290. PMID:31020314<ref>PMID:31020314</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ib7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Inositol monophosphatase 3D structures\|Inositol monophosphatase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Inositol-phosphate phosphatase]]		[[Category: Inositol-phosphate phosphatase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 05:58, 17 April 2019

OCA — Wed, 17 Apr 2019 05:58:36 GMT

←Older revision		Revision as of 05:58, 17 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ib7 is ~~ON HOLD until Nov 29 2020~~	+	==Structure of wild type SuhB==
-		+	<StructureSection load='6ib7' size='340' side='right'caption='[[6ib7]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~Authors~~: ~~Huang~~, Y.H., ~~Loll~~, B., ~~Wahl~~, M.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ib7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IB7 FirstGlance]. <br>
-	~~Description~~: ~~Structure of wild type SuhB~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ib7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ib7 OCA], [http://pdbe.org/6ib7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ib7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ib7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ib7 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Inositol-phosphate phosphatase]]
		+	[[Category: Large Structures]]
		+	[[Category: Huang, Y H]]
	[[Category: Loll, B]]		[[Category: Loll, B]]
-	[[Category: ~~Huang~~, ~~Y.H~~]]	+	[[Category: Wahl, M C]]
-	[[Category: ~~Wahl, M.C~~]]	+	[[Category: Antitermiantion]]
		+	[[Category: Suhb]]
		+	[[Category: Transcription]]

OCA at 05:04, 12 December 2018

OCA — Wed, 12 Dec 2018 05:04:56 GMT

←Older revision		Revision as of 05:04, 12 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ib7 is ON HOLD	+	The entry 6ib7 is ON HOLD until Nov 29 2020

	Authors: Huang, Y.H., Loll, B., Wahl, M.C.		Authors: Huang, Y.H., Loll, B., Wahl, M.C.

-	Description: Structure of ~~a complex of~~ SuhB ~~and NusA AR2 domain~~	+	Description: Structure of wild type SuhB
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Loll, B]]		[[Category: Loll, B]]
	[[Category: Huang, Y.H]]		[[Category: Huang, Y.H]]
	[[Category: Wahl, M.C]]		[[Category: Wahl, M.C]]

OCA: Protected "6ib7" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2018 05:05:01 GMT

Protected "6ib7" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:05, 5 December 2018

OCA: New page: '''Unreleased structure''' The entry 6ib7 is ON HOLD Authors: Huang, Y.H., Loll, B., Wahl, M.C. Description: Structure of a complex of SuhB and NusA AR2 domain [[Category: Unreleased S...

OCA — Wed, 05 Dec 2018 05:04:59 GMT

New page: '''Unreleased structure''' The entry 6ib7 is ON HOLD Authors: Huang, Y.H., Loll, B., Wahl, M.C. Description: Structure of a complex of SuhB and NusA AR2 domain [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 6ib7 is ON HOLD

Authors: Huang, Y.H., Loll, B., Wahl, M.C.

Description: Structure of a complex of SuhB and NusA AR2 domain
[[Category: Unreleased Structures]]
[[Category: Loll, B]]
[[Category: Huang, Y.H]]
[[Category: Wahl, M.C]]