OCA at 09:36, 22 November 2023

OCA — Wed, 22 Nov 2023 09:36:56 GMT

←Older revision		Revision as of 09:36, 22 November 2023
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	==Crystal structure of Hamster MIF==		==Crystal structure of Hamster MIF==
-	<StructureSection load='6ice' size='340' side='right'caption='[[6ice]]' scene=''>	+	<StructureSection load='6ice' size='340' side='right'caption='[[6ice]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ICE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ICE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ice]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ICE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ICE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ice FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ice OCA], [~~http~~://pdbe.org/6ice PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ice RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ice PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ice ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ice FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ice OCA], [https://pdbe.org/6ice PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ice RCSB], [https://www.ebi.ac.uk/pdbsum/6ice PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ice ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A140EDM8_MESAU A0A140EDM8_MESAU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that increasingly is being studied in cancers and inflammatory diseases. Though murine models have been instrumental in understanding the functional role of MIF in different pathological conditions, the information obtained from these models is biased towards a specific species. In experimental science, results obtained from multiple clinically relevant animal models always provide convincing data that might recapitulate in humans. Syrian golden hamster (Mesocricetus auratus), is a clinically relevant animal model for multiple human diseases. Hence, the major objectives of this study were to characterize the structure and function of Mesocricetus auratus MIF (MaMIF) and finally evaluate its effect on pancreatic tumor growth in vivo. Initially, the recombinant MaMIF was cloned, expressed and purified in a bacterial expression system. The MaMIF primary sequence, biochemical properties, and crystal structure analysis showed greater similarity with human MIF. The crystal structure of MaMIF illustrates that it forms a homotrimer as known in human and mouse. However, MaMIF exhibits some minor structural variations when compared to human and mouse MIF. The in vitro functional studies show that MaMIF has tautomerase activity and enhances activation and migration of hamster peripheral blood mononuclear cells (PBMCs). Interestingly, injection of MaMIF into HapT1 pancreatic tumor-bearing hamsters significantly enhanced the tumor growth and tumor-associated angiogenesis. Together, the current study shows a structural and functional similarity between the hamster and human MIF. Moreover, it has demonstrated that a high level of circulating MIF originating from non-tumor cells might also promote pancreatic tumor growth in vivo.
		+
		+	Macrophage migration inhibitory factor of Syrian golden hamster shares structural and functional similarity with human counterpart and promotes pancreatic cancer.,Suresh V, Sundaram R, Dash P, Sabat SC, Mohapatra D, Mohanty S, Vasudevan D, Senapati S Sci Rep. 2019 Oct 29;9(1):15507. doi: 10.1038/s41598-019-51947-7. PMID:31664114<ref>PMID:31664114</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ice" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]		*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mesocricetus auratus]]
	[[Category: Sundaram R]]		[[Category: Sundaram R]]
	[[Category: Vasudevan D]]		[[Category: Vasudevan D]]

OCA at 11:21, 23 September 2020

OCA — Wed, 23 Sep 2020 11:21:53 GMT

←Older revision		Revision as of 11:21, 23 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ice is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Hamster MIF==
		+	<StructureSection load='6ice' size='340' side='right'caption='[[6ice]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ICE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ICE FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ice FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ice OCA], [http://pdbe.org/6ice PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ice RCSB], [http://www.ebi.ac.uk/pdbsum/6ice PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ice ProSAT]</span></td></tr>
		+	</table>

-	~~Authors:~~	+	==See Also==
-		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
-	~~Description:~~	+	__TOC__
-	[[Category: ~~Unreleased~~ Structures]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Sundaram R]]
		+	[[Category: Vasudevan D]]

OCA at 18:16, 19 September 2018

OCA — Wed, 19 Sep 2018 18:16:31 GMT

←Older revision		Revision as of 18:16, 19 September 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ice is ON HOLD	+	The entry 6ice is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ice" [edit=sysop:move=sysop]

OCA — Wed, 12 Sep 2018 06:08:36 GMT

Protected "6ice" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:08, 12 September 2018

OCA: New page: '''Unreleased structure''' The entry 6ice is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Sep 2018 06:08:35 GMT

New page: '''Unreleased structure''' The entry 6ice is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ice is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6ice - Revision history

OCA at 09:36, 22 November 2023

OCA at 11:21, 23 September 2020

OCA at 18:16, 19 September 2018

OCA: Protected "6ice" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6ice is ON HOLD Authors: Description: Category: Unreleased Structures