6ieb - Revision history

OCA at 06:24, 10 July 2019

OCA — Wed, 10 Jul 2019 06:24:53 GMT

←Older revision		Revision as of 06:24, 10 July 2019
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	<StructureSection load='6ieb' size='340' side='right'caption='[[6ieb]], [[Resolution\|resolution]] 2.41Å' scene=''>		<StructureSection load='6ieb' size='340' side='right'caption='[[6ieb]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ieb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IEB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ieb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IEB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ieb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ieb OCA], [http://pdbe.org/6ieb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ieb RCSB], [http://www.ebi.ac.uk/pdbsum/6ieb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ieb ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ieb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ieb OCA], [http://pdbe.org/6ieb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ieb RCSB], [http://www.ebi.ac.uk/pdbsum/6ieb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ieb ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Rvfv]]
	[[Category: Gao, F]]		[[Category: Gao, F]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]
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	[[Category: Wu, Y]]		[[Category: Wu, Y]]
	[[Category: Antibody]]		[[Category: Antibody]]
-	[[Category: Rvfv]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
	[[Category: Structural protein-immune system complex]]		[[Category: Structural protein-immune system complex]]

OCA at 07:22, 10 April 2019

OCA — Wed, 10 Apr 2019 07:22:22 GMT

←Older revision		Revision as of 07:22, 10 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ieb is ~~ON HOLD~~	+	==Structure of RVFV Gn and human monoclonal antibody R15==
		+	<StructureSection load='6ieb' size='340' side='right'caption='[[6ieb]], [[Resolution\|resolution]] 2.41Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ieb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IEB FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ieb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ieb OCA], [http://pdbe.org/6ieb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ieb RCSB], [http://www.ebi.ac.uk/pdbsum/6ieb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ieb ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rift Valley fever virus (RVFV) is a mosquito-borne pathogen that causes substantial morbidity and mortality in livestock and humans. To date, there are no licensed human vaccines or therapeutics available. Here, we report the isolation of monoclonal antibodies from a convalescent patient, targeting the RVFV envelope proteins Gn and Gc. The Gn-specific monoclonal antibodies exhibited much higher neutralizing activities in vitro and protection efficacies in mice against RVFV infection, compared to the Gc-specific monoclonal antibodies. The Gn monoclonal antibodies were found to interfere with soluble Gn binding to cells and prevent infection by blocking the attachment of virions to host cells. Structural analysis of Gn complexed with four Gn-specific monoclonal antibodies resulted in the definition of three antigenic patches (A, B and C) on Gn domain I. Both patches A and B are major neutralizing epitopes. Our results highlight the potential of antibody-based therapeutics and provide a structure-based rationale for designing vaccines against RVFV.

-	~~Authors: Wang~~, Q~~.H.~~, Wu, Y., ~~Gao~~, F., Qi, J~~.X.~~, Gao, G.F.	+	Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.,Wang Q, Ma T, Wu Y, Chen Z, Zeng H, Tong Z, Gao F, Qi J, Zhao Z, Chai Y, Yang H, Wong G, Bi Y, Wu L, Shi R, Yang M, Song J, Jiang H, An Z, Wang J, Yilma TD, Shi Y, Liu WJ, Liang M, Qin C, Gao GF, Yan J Nat Microbiol. 2019 Apr 1. pii: 10.1038/s41564-019-0411-z. doi:, 10.1038/s41564-019-0411-z. PMID:30936489<ref>PMID:30936489</ref>

-	~~Description: Structure~~ of ~~RVFV Gn and human monoclonal antibody R15~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Qi, J.X]]~~	+	<div class="pdbe-citations 6ieb" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Gao, G.F~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gao, F]]		[[Category: Gao, F]]
-	[[Category: Wang, Q.H]]	+	[[Category: Gao, G F]]
		+	[[Category: Qi, J X]]
		+	[[Category: Wang, Q H]]
	[[Category: Wu, Y]]		[[Category: Wu, Y]]
		+	[[Category: Antibody]]
		+	[[Category: Rvfv]]
		+	[[Category: Structural protein]]
		+	[[Category: Structural protein-immune system complex]]

OCA: Protected "6ieb" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2018 18:20:22 GMT

Protected "6ieb" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:20, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6ieb is ON HOLD Authors: Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. Description: Structure of RVFV Gn and human monoclonal antibody R15 [[Cat...

OCA — Wed, 19 Sep 2018 18:20:21 GMT

New page: '''Unreleased structure''' The entry 6ieb is ON HOLD Authors: Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. Description: Structure of RVFV Gn and human monoclonal antibody R15 [[Cat...

New page

'''Unreleased structure'''

The entry 6ieb is ON HOLD

Authors: Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F.

Description: Structure of RVFV Gn and human monoclonal antibody R15
[[Category: Unreleased Structures]]
[[Category: Qi, J.X]]
[[Category: Gao, G.F]]
[[Category: Gao, F]]
[[Category: Wang, Q.H]]
[[Category: Wu, Y]]