6iej - Revision history

OCA at 09:39, 22 November 2023

OCA — Wed, 22 Nov 2023 09:39:44 GMT

←Older revision		Revision as of 09:39, 22 November 2023
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	<StructureSection load='6iej' size='340' side='right'caption='[[6iej]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='6iej' size='340' side='right'caption='[[6iej]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6iej]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IEJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6iej]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IEJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HXG:1~~,2~~-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>HXG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.206Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PLA2G4A, CPLA2, PLA2G4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9031 CHICK])</td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HXG:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>HXG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iej OCA], [https://pdbe.org/6iej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iej RCSB], [https://www.ebi.ac.uk/pdbsum/6iej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iej ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iej OCA], [https://pdbe.org/6iej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iej RCSB], [https://www.ebi.ac.uk/pdbsum/6iej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iej ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PA24A_CHICK PA24A_CHICK]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brown~~, R E~~]]	+	[[Category: Brown RE]]
-	[[Category: Chalfant~~, C E~~]]	+	[[Category: Chalfant CE]]
-	[[Category: Gao~~, Y G~~]]	+	[[Category: Gao YG]]
-	[[Category: Hirano, Y]]	+	[[Category: Hirano Y]]
-	[[Category: Malinina, L]]	+	[[Category: Malinina L]]
-	[[Category: Patel~~, D J~~]]	+	[[Category: Patel DJ]]
-	[[Category: Stephenson~~, D J~~]]	+	[[Category: Stephenson DJ]]
-	[[Category: Vu~~, N T]]~~	+	[[Category: Vu NT]]
-	~~[[Category: C2 domain]]~~	+
-	~~[[Category: Calcium binding]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lipid binding]]~~	+
-	~~[[Category: Phospholipase~~]]	+

OCA at 11:42, 23 March 2022

OCA — Wed, 23 Mar 2022 11:42:10 GMT

←Older revision		Revision as of 11:42, 23 March 2022
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	<StructureSection load='6iej' size='340' side='right'caption='[[6iej]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='6iej' size='340' side='right'caption='[[6iej]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6iej]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IEJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6iej]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IEJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HXG:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>HXG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HXG:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>HXG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G4A, CPLA2, PLA2G4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6iej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iej OCA], [~~http~~://pdbe.org/6iej PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6iej RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6iej PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6iej ProSAT]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iej OCA], [https://pdbe.org/6iej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iej RCSB], [https://www.ebi.ac.uk/pdbsum/6iej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iej ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6iej" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6iej" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chick]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brown, R E]]		[[Category: Brown, R E]]

OCA at 06:49, 23 May 2019

OCA — Thu, 23 May 2019 06:49:25 GMT

←Older revision		Revision as of 06:49, 23 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6iej is ~~ON HOLD until Paper~~ Publication	+	==The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine==
		+	<StructureSection load='6iej' size='340' side='right'caption='[[6iej]], [[Resolution\|resolution]] 2.21Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6iej]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IEJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HXG:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>HXG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iej OCA], [http://pdbe.org/6iej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iej RCSB], [http://www.ebi.ac.uk/pdbsum/6iej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iej ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ca(2+)-stimulated translocation of cytosolic phospholipase A2alpha (cPLA2alpha) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA2alpha preference for phosphatidylcholine (PC)-enriched membranes have remained elusive. Here, we report cPLA2alpha C2-domain structure (2.2A resolution) containing bound 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) and Ca(2+) ions. Two Ca(2+) are complexed at locations previously reported for lipid-free C2-domain. One of these Ca(2+) along with a third Ca(2+) bridge the C2-domain to the DHPC phosphate group, which also interacts with Asn65. Tyr96 plays a key role in lipid headgroup recognition via cation-pi interaction with the PC trimethylammonium group. Mutagenesis analyses confirm Tyr96 and Asn65 function in PC binding selectivity by C2-domain and regulation of cPLA2alpha activity. The differing DHPC-binding mode of cPLA2alpha C2-domain, compared to phosphatidylserine or phosphatidylinositol 4,5-bisphosphate binding by other C2-domains, expands and deepens knowledge of lipid-binding mechanisms mediated by C2-domains.

-	~~Authors~~:	+	Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha.,Hirano Y, Gao YG, Stephenson DJ, Vu NT, Malinina L, Simanshu DK, Chalfant CE, Patel DJ, Brown RE Elife. 2019 May 3;8. pii: 44760. doi: 10.7554/eLife.44760. PMID:31050338<ref>PMID:31050338</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6iej" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Brown, R E]]
		+	[[Category: Chalfant, C E]]
		+	[[Category: Gao, Y G]]
		+	[[Category: Hirano, Y]]
		+	[[Category: Malinina, L]]
		+	[[Category: Patel, D J]]
		+	[[Category: Stephenson, D J]]
		+	[[Category: Vu, N T]]
		+	[[Category: C2 domain]]
		+	[[Category: Calcium binding]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lipid binding]]
		+	[[Category: Phospholipase]]

OCA at 06:19, 3 October 2018

OCA — Wed, 03 Oct 2018 06:19:35 GMT

←Older revision		Revision as of 06:19, 3 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6iej is ON HOLD	+	The entry 6iej is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6iej" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2018 18:20:53 GMT

Protected "6iej" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:20, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6iej is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Sep 2018 18:20:52 GMT

New page: '''Unreleased structure''' The entry 6iej is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6iej is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]