6ig5 - Revision history

OCA at 09:40, 22 November 2023

OCA — Wed, 22 Nov 2023 09:40:54 GMT

←Older revision		Revision as of 09:40, 22 November 2023
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	<StructureSection load='6ig5' size='340' side='right'caption='[[6ig5]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='6ig5' size='340' side='right'caption='[[6ig5]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ig5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IG5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ig5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IG5 FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Argininosuccinate_lyase Argininosuccinate lyase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.~~2.~~1 4.3.2.1] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.078Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ig5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ig5 OCA], [https://pdbe.org/6ig5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ig5 RCSB], [https://www.ebi.ac.uk/pdbsum/6ig5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ig5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ig5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ig5 OCA], [https://pdbe.org/6ig5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ig5 RCSB], [https://www.ebi.ac.uk/pdbsum/6ig5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ig5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ARLY_MYCTU ARLY_MYCTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Argininosuccinate lyase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, X B~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: ~~Liu, X~~]]	+	[[Category: Chen XB]]
-	[[Category: ~~Fumarate]]~~	+	[[Category: Liu X]]
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Tetrameric structure~~]]	+

OCA at 10:28, 18 March 2021

OCA — Thu, 18 Mar 2021 10:28:03 GMT

←Older revision		Revision as of 10:28, 18 March 2021
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	==Crystal structure of argininosuccinate lyase from Mycobacterium tuberculosis==		==Crystal structure of argininosuccinate lyase from Mycobacterium tuberculosis==
-	<StructureSection load='6ig5' size='340' side='right' caption='[[6ig5]], [[Resolution\|resolution]] 2.08Å' scene=''>	+	<StructureSection load='6ig5' size='340' side='right'caption='[[6ig5]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ig5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IG5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IG5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ig5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IG5 FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Argininosuccinate_lyase Argininosuccinate lyase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.2.1 4.3.2.1] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Argininosuccinate_lyase Argininosuccinate lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.2.1 4.3.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ig5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ig5 OCA], [~~http~~://pdbe.org/6ig5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ig5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ig5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ig5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ig5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ig5 OCA], [https://pdbe.org/6ig5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ig5 RCSB], [https://www.ebi.ac.uk/pdbsum/6ig5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ig5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Argininosuccinate lyase]]		[[Category: Argininosuccinate lyase]]
		+	[[Category: Large Structures]]
	[[Category: Chen, X B]]		[[Category: Chen, X B]]
	[[Category: Liu, X]]		[[Category: Liu, X]]

OCA at 09:53, 13 February 2019

OCA — Wed, 13 Feb 2019 09:53:59 GMT

←Older revision		Revision as of 09:53, 13 February 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ig5 is ~~ON HOLD until Sep 24 2020~~	+	==Crystal structure of argininosuccinate lyase from Mycobacterium tuberculosis==
		+	<StructureSection load='6ig5' size='340' side='right' caption='[[6ig5]], [[Resolution\|resolution]] 2.08Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ig5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IG5 FirstGlance]. <br>
		+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Argininosuccinate_lyase Argininosuccinate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.2.1 4.3.2.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ig5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ig5 OCA], [http://pdbe.org/6ig5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ig5 RCSB], [http://www.ebi.ac.uk/pdbsum/6ig5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ig5 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Argininosuccinate lyase (ASL) participates in arginine synthesis through catalysing a reversible reaction in which argininosuccinate (AS) converts into arginine and fumarate. ASL from Mycobacterium tuberculosis is essential for its growth. In this work, the crystal structure of the apo form of MtbASL was determined and reveals a tetrameric structure that is essential for its activity since the active sites are formed by residues from three different monomers. Subsequently, we determined the crystal structure of MtbASL-sulfate complex, and the ligand mimics the negatively charged intermediate. The complex structure and mutagenesis studies indicate that residues S282 and H161 might act as a catalytic dyad. A major conformational change in the MtbASL-SO4 complex structure could be observed upon sulfate binding, and this movement facilitates the interaction between substrate and the residues involved in catalysis. A different conformational change in the C-terminal domain could be observed in the MtbASL-SO4 complex compared with that in other homologues. This difference may be responsible for the lower activity of MtbASL, which is related to the slow growth rate of M. tuberculosis. The C-terminal domain is a potential allosteric site upon inhibitor binding. The various conformational changes and the diversity of the sequence of the potential allosteric site across the homologues might provide clues for designing selective inhibitors against M. tuberculosis.

-	~~Authors~~:	+	Crystal structure and biochemical study on argininosuccinate lyase from Mycobacterium tuberculosis.,Chen X, Chen J, Zhang W, Wang H, Liu X, Zhou W, Yang H, Rao Z Biochem Biophys Res Commun. 2019 Feb 26;510(1):116-121. doi:, 10.1016/j.bbrc.2019.01.061. Epub 2019 Jan 18. PMID:30665717<ref>PMID:30665717</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6ig5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Argininosuccinate lyase]]
		+	[[Category: Chen, X B]]
		+	[[Category: Liu, X]]
		+	[[Category: Fumarate]]
		+	[[Category: Lyase]]
		+	[[Category: Tetrameric structure]]

OCA at 06:22, 17 October 2018

OCA — Wed, 17 Oct 2018 06:22:23 GMT

←Older revision		Revision as of 06:22, 17 October 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ig5 is ON HOLD	+	The entry 6ig5 is ON HOLD until Sep 24 2020

	Authors:		Authors:

OCA: Protected "6ig5" [edit=sysop:move=sysop]

OCA — Wed, 03 Oct 2018 06:20:19 GMT

Protected "6ig5" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:20, 3 October 2018

OCA: New page: '''Unreleased structure''' The entry 6ig5 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Oct 2018 06:20:18 GMT

New page: '''Unreleased structure''' The entry 6ig5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ig5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]