6itp - Revision history

OCA at 09:52, 22 November 2023

OCA — Wed, 22 Nov 2023 09:52:54 GMT

←Older revision		Revision as of 09:52, 22 November 2023
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	<StructureSection load='6itp' size='340' side='right'caption='[[6itp]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='6itp' size='340' side='right'caption='[[6itp]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6itp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ITP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6itp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_bactrianus Camelus bactrianus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ITP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HCY:(11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE'>HCY</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.572Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6itp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6itp OCA], [~~http~~://pdbe.org/6itp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6itp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6itp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6itp ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HCY:(11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE'>HCY</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6itp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6itp OCA], [https://pdbe.org/6itp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6itp RCSB], [https://www.ebi.ac.uk/pdbsum/6itp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6itp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6itp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6itp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Camelus bactrianus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ding~~, L L~~]]	+	[[Category: Ding LL]]
-	[[Category: Ding, Y]]	+	[[Category: Ding Y]]
-	[[Category: Wang~~, Z Y~~]]	+	[[Category: Wang ZY]]
-	[[Category: Zhong~~, P Y]]~~	+	[[Category: Zhong PY]]
-	~~[[Category: Camelid antibody]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Cortisol]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Nanobody~~]]	+

OCA at 06:12, 24 July 2019

OCA — Wed, 24 Jul 2019 06:12:16 GMT

←Older revision		Revision as of 06:12, 24 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6itp is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of cortisol complexed with its nanobody at pH 3.5==
		+	<StructureSection load='6itp' size='340' side='right'caption='[[6itp]], [[Resolution\|resolution]] 1.57Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6itp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ITP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HCY:(11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE'>HCY</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6itp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6itp OCA], [http://pdbe.org/6itp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6itp RCSB], [http://www.ebi.ac.uk/pdbsum/6itp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6itp ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To date, few structural models of VHH antibody binding to low molecular weight haptens have been reported. Here, we report the crystal structure of cortisol binding to its VHH antibody NbCor at pH 3.5 and 10.5. Cortisol binds to NbCor mainly by burying itself under the tunnel formed by the complementarity determining region 1 (CDR1) of NbCor. The affinity of NbCor binding to cortisol and similar compounds was also verified by a microscale thermophoresis assay. Combining our findings with several previously reported structures of hapten-VHH antibody complexes, we propose that VHH antibodies exhibit a special mechanism of binding small haptens by encapsulating them in a tunnel formed by CDR1. Our findings provide useful structural information for the further development and optimization of hapten-specific VHH antibodies.

-	~~Authors: Ding, Y~~., Ding, L~~.L.~~, Wang, Z.Y., ~~Zhong~~, P.Y.	+	Structural insights into the mechanism of single domain VHH antibody binding to cortisol.,Ding L, Wang Z, Zhong P, Jiang H, Zhao Z, Zhang Y, Ren Z, Ding Y FEBS Lett. 2019 Jun;593(11):1248-1256. doi: 10.1002/1873-3468.13398. Epub 2019, May 20. PMID:31049949<ref>PMID:31049949</ref>

-	~~Description: Crystal structure~~ of ~~cortisol complexed with its nanobody at pH 3~~.5	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Zhong~~, ~~P.Y~~]]	+	<div class="pdbe-citations 6itp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ding, L L]]
	[[Category: Ding, Y]]		[[Category: Ding, Y]]
-	[[Category: ~~Ding~~, ~~L.L~~]]	+	[[Category: Wang, Z Y]]
-	[[Category: ~~Wang~~, Z.Y]]	+	[[Category: Zhong, P Y]]
		+	[[Category: Camelid antibody]]
		+	[[Category: Complex]]
		+	[[Category: Cortisol]]
		+	[[Category: Immune system]]
		+	[[Category: Nanobody]]

OCA at 05:10, 12 December 2018

OCA — Wed, 12 Dec 2018 05:10:14 GMT

←Older revision		Revision as of 05:10, 12 December 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6itp is ON HOLD	+	The entry 6itp is ON HOLD until Paper Publication

	Authors: Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y.		Authors: Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y.

OCA: Protected "6itp" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2018 05:09:48 GMT

Protected "6itp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:09, 5 December 2018

OCA: New page: '''Unreleased structure''' The entry 6itp is ON HOLD Authors: Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y. Description: Crystal structure of cortisol complexed with its nanobody at pH...

OCA — Wed, 05 Dec 2018 05:09:46 GMT

New page: '''Unreleased structure''' The entry 6itp is ON HOLD Authors: Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y. Description: Crystal structure of cortisol complexed with its nanobody at pH...

New page

'''Unreleased structure'''

The entry 6itp is ON HOLD

Authors: Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y.

Description: Crystal structure of cortisol complexed with its nanobody at pH 3.5
[[Category: Unreleased Structures]]
[[Category: Zhong, P.Y]]
[[Category: Ding, Y]]
[[Category: Ding, L.L]]
[[Category: Wang, Z.Y]]