6ivk - Revision history

OCA at 19:26, 29 May 2024

OCA — Wed, 29 May 2024 19:26:41 GMT

←Older revision		Revision as of 19:26, 29 May 2024
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	<StructureSection load='6ivk' size='340' side='right'caption='[[6ivk]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6ivk' size='340' side='right'caption='[[6ivk]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ivk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus~~ pneumoniae~~" (schroeter 1886) flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ivk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yneE, AGG09_26735, B1727_16705, B4U21_14105, B4U25_16730, B4U27_02655, B4U30_16350, B4U35_20780, BB785_13310, BN49_2925, C3483_12335, C7V41_19985, CPT10_17935, CWN54_25435, CWQ24_13475, DM060_34770, DM071_16710, DM078_14870, DM083_28480, DMR37_19630, DXF97_13395, NCTC11679_02573, NCTC13465_00112, NCTC5052_01714, NCTC8849_03195, NCTC9637_03467, NCTC9645_05950, NCTC9661_03571, SAMEA104305404_11875, SAMEA23986918_00256, SAMEA24002668_02597, SAMEA24012418_00268, SAMEA3649709_04169, SAMEA3673019_02937, SAMEA3727643_02313, SAMEA4394730_00268 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivk OCA], [https://pdbe.org/6ivk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivk RCSB], [https://www.ebi.ac.uk/pdbsum/6ivk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivk OCA], [https://pdbe.org/6ivk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivk RCSB], [https://www.ebi.ac.uk/pdbsum/6ivk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/W9BH30_KLEPN W9BH30_KLEPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6ivk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ivk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bestrophin 3D structures\|Bestrophin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fukuda, F]]	+	[[Category: Fukuda F]]
-	[[Category: Kittredge, A]]	+	[[Category: Kittredge A]]
-	[[Category: Yang, T]]	+	[[Category: Yang T]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Membrane protein~~]]	+

OCA at 11:42, 23 March 2022

OCA — Wed, 23 Mar 2022 11:42:19 GMT

←Older revision		Revision as of 11:42, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='6ivk' size='340' side='right'caption='[[6ivk]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6ivk' size='340' side='right'caption='[[6ivk]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ivk]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IVK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ivk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=6ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivk OCA], [~~http~~://pdbe.org/6ivk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ivk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ivk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivk ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yneE, AGG09_26735, B1727_16705, B4U21_14105, B4U25_16730, B4U27_02655, B4U30_16350, B4U35_20780, BB785_13310, BN49_2925, C3483_12335, C7V41_19985, CPT10_17935, CWN54_25435, CWQ24_13475, DM060_34770, DM071_16710, DM078_14870, DM083_28480, DMR37_19630, DXF97_13395, NCTC11679_02573, NCTC13465_00112, NCTC5052_01714, NCTC8849_03195, NCTC9637_03467, NCTC9645_05950, NCTC9661_03571, SAMEA104305404_11875, SAMEA23986918_00256, SAMEA24002668_02597, SAMEA24012418_00268, SAMEA3649709_04169, SAMEA3673019_02937, SAMEA3727643_02313, SAMEA4394730_00268 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivk OCA], [https://pdbe.org/6ivk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivk RCSB], [https://www.ebi.ac.uk/pdbsum/6ivk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:37, 6 November 2019

OCA — Wed, 06 Nov 2019 06:37:05 GMT

←Older revision		Revision as of 06:37, 6 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ivk is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of a membrane protein G175A==
		+	<StructureSection load='6ivk' size='340' side='right'caption='[[6ivk]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ivk]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IVK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivk OCA], [http://pdbe.org/6ivk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ivk RCSB], [http://www.ebi.ac.uk/pdbsum/6ivk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivk ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mutations of human BEST1, encoding a Ca(2+)-activated Cl(-) channel (hBest1), cause macular degenerative disorders. Best1 homolog structures reveal an evolutionarily conserved channel architecture highlighted by two landmark restrictions (named the "neck" and "aperture", respectively) in the ion conducting pathway, suggesting a unique dual-switch gating mechanism, which, however, has not been characterized well. Using patch clamp and crystallography, we demonstrate that both the neck and aperture in hBest1 are Ca(2+)-dependent gates essential for preventing channel leakage resulting from Ca(2+)-independent, spontaneous gate opening. Importantly, three patient-derived mutations (D203A, I205T and Y236C) lead to Ca(2+)-independent leakage and elevated Ca(2+)-dependent anion currents due to enhanced opening of the gates. Moreover, we identify a network of residues critically involved in gate operation. Together, our results suggest an indispensable role of the neck and aperture of hBest1 for channel gating, and uncover disease-causing mechanisms of hBest1 gain-of-function mutations.

-	~~Authors:~~ Kittredge, A., ~~Fukuda~~, F., ~~Zhang~~, Y., Yang, T.	+	Dual Ca(2+)-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.,Ji C, Kittredge A, Hopiavuori A, Ward N, Chen S, Fukuda Y, Zhang Y, Yang T Commun Biol. 2019 Jun 24;2:240. doi: 10.1038/s42003-019-0433-3. eCollection 2019. PMID:31263784<ref>PMID:31263784</ref>

-	~~Description: Crystal structure of~~ a ~~membrane protein G175A~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Kittredge, A~~]]	+	<div class="pdbe-citations 6ivk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Fukuda, F]]		[[Category: Fukuda, F]]
-	[[Category: ~~Zhang~~, Y]]	+	[[Category: Kittredge, A]]
	[[Category: Yang, T]]		[[Category: Yang, T]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Membrane protein]]

OCA at 09:55, 13 March 2019

OCA — Wed, 13 Mar 2019 09:55:31 GMT

←Older revision		Revision as of 09:55, 13 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ivk is ON HOLD	+	The entry 6ivk is ON HOLD until Paper Publication

	Authors: Kittredge, A., Fukuda, F., Zhang, Y., Yang, T.		Authors: Kittredge, A., Fukuda, F., Zhang, Y., Yang, T.
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	Description: Crystal structure of a membrane protein G175A		Description: Crystal structure of a membrane protein G175A
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Zhang, Y]]
	[[Category: Kittredge, A]]		[[Category: Kittredge, A]]
	[[Category: Fukuda, F]]		[[Category: Fukuda, F]]
		+	[[Category: Zhang, Y]]
	[[Category: Yang, T]]		[[Category: Yang, T]]

OCA: Protected "6ivk" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2018 05:12:49 GMT

Protected "6ivk" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:12, 12 December 2018

OCA: New page: '''Unreleased structure''' The entry 6ivk is ON HOLD Authors: Kittredge, A., Fukuda, F., Zhang, Y., Yang, T. Description: Crystal structure of a membrane protein G175A [[Category: Unre...

OCA — Wed, 12 Dec 2018 05:12:48 GMT

New page: '''Unreleased structure''' The entry 6ivk is ON HOLD Authors: Kittredge, A., Fukuda, F., Zhang, Y., Yang, T. Description: Crystal structure of a membrane protein G175A [[Category: Unre...

New page

'''Unreleased structure'''

The entry 6ivk is ON HOLD

Authors: Kittredge, A., Fukuda, F., Zhang, Y., Yang, T.

Description: Crystal structure of a membrane protein G175A
[[Category: Unreleased Structures]]
[[Category: Zhang, Y]]
[[Category: Kittredge, A]]
[[Category: Fukuda, F]]
[[Category: Yang, T]]