6ivz - Revision history

OCA at 16:02, 27 February 2019

OCA — Wed, 27 Feb 2019 16:02:24 GMT

←Older revision		Revision as of 16:02, 27 February 2019
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	<StructureSection load='6ivz' size='340' side='right' caption='[[6ivz]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6ivz' size='340' side='right' caption='[[6ivz]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ivz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ivz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Flavivirus_febricis Flavivirus febricis] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IVZ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivz OCA], [http://pdbe.org/6ivz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ivz RCSB], [http://www.ebi.ac.uk/pdbsum/6ivz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivz ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivz OCA], [http://pdbe.org/6ivz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ivz RCSB], [http://www.ebi.ac.uk/pdbsum/6ivz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivz ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Flavivirus febricis]]
		+	[[Category: Human]]
	[[Category: Li, S H]]		[[Category: Li, S H]]
	[[Category: Lu, X S]]		[[Category: Lu, X S]]

OCA at 09:33, 13 February 2019

OCA — Wed, 13 Feb 2019 09:33:45 GMT

←Older revision		Revision as of 09:33, 13 February 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ivz is ~~ON HOLD~~	+	==Crystal structure of 5A ScFv complexed with YFV-China sE in postfusion state==
		+	<StructureSection load='6ivz' size='340' side='right' caption='[[6ivz]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ivz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IVZ FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivz OCA], [http://pdbe.org/6ivz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ivz RCSB], [http://www.ebi.ac.uk/pdbsum/6ivz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivz ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Yellow fever virus (YFV), a deadly human pathogen, is the prototype of the genus Flavivirus. Recently, YFV re-emerged in Africa and Brazil, leading to hundreds of deaths, with some cases imported to China. Prophylactic or therapeutic countermeasures are urgently needed. Previously, several human monoclonal antibodies against YFV were screened out by phage display. Here, we find that one of them, 5A, exhibits high neutralizing potency and good protection. Crystallographic analysis of the YFV envelope (E) protein in its pre- and post-fusion states shows conformations similar to those observed in other E proteins of flaviviruses. Furthermore, the structures of 5A in complex with the E protein in both states are resolved, revealing an invariant recognition site. Structural analysis and functional data suggest that 5A has high neutralization potency because it interferes with virus entry by preventing both virus attachment and fusion. These findings will be instrumental for immunogen or inhibitor design.

-	~~Authors~~:	+	Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.,Lu X, Xiao H, Li S, Pang X, Song J, Liu S, Cheng H, Li Y, Wang X, Huang C, Guo T, Ter Meulen J, Daffis S, Yan J, Dai L, Rao Z, Klenk HD, Qi J, Shi Y, Gao GF Cell Rep. 2019 Jan 8;26(2):438-446.e5. doi: 10.1016/j.celrep.2018.12.065. PMID:30625326<ref>PMID:30625326</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6ivz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Li, S H]]
		+	[[Category: Lu, X S]]
		+	[[Category: Pang, X F]]
		+	[[Category: Xiao, H X]]
		+	[[Category: Envelope protein]]
		+	[[Category: Flavivirus]]
		+	[[Category: Neutralizing monoclonal antibody]]
		+	[[Category: Viral protein]]
		+	[[Category: Viral protein-immune system complex]]
		+	[[Category: Yellow fever virus]]

OCA: Protected "6ivz" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2018 05:13:51 GMT

Protected "6ivz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:13, 12 December 2018

OCA: New page: '''Unreleased structure''' The entry 6ivz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Dec 2018 05:13:50 GMT

New page: '''Unreleased structure''' The entry 6ivz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ivz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]