6iwj - Revision history

OCA at 10:52, 14 June 2023

OCA — Wed, 14 Jun 2023 10:52:14 GMT

←Older revision		Revision as of 10:52, 14 June 2023
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	==A designed domain swapped dimer==		==A designed domain swapped dimer==
-	<StructureSection load='6iwj' size='340' side='right' caption='[[6iwj~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6iwj' size='340' side='right'caption='[[6iwj]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6iwj]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IWJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6iwj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanopyrus_kandleri_AV19 Methanopyrus kandleri AV19]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IWJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6iwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iwj OCA], [~~http~~://pdbe.org/6iwj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6iwj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6iwj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6iwj ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iwj OCA], [https://pdbe.org/6iwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iwj RCSB], [https://www.ebi.ac.uk/pdbsum/6iwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iwj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8TYK3_METKA Q8TYK3_METKA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Das, R~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Nandwani, N~~]]	+	[[Category: Methanopyrus kandleri AV19]]
-	[[Category: ~~Negi, H~~]]	+	[[Category: Das R]]
-	[[Category: ~~Archea~~]]	+	[[Category: Nandwani N]]
-	[[Category: ~~Complex]]~~	+	[[Category: Negi H]]
-	~~[[Category: Domain-swapping]]~~	+
-	~~[[Category: Protein design]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 09:34, 13 February 2019

OCA — Wed, 13 Feb 2019 09:34:02 GMT

←Older revision		Revision as of 09:34, 13 February 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6iwj is ~~ON HOLD until Paper~~ Publication	+	==A designed domain swapped dimer==
		+	<StructureSection load='6iwj' size='340' side='right' caption='[[6iwj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6iwj]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IWJ FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iwj OCA], [http://pdbe.org/6iwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iwj RCSB], [http://www.ebi.ac.uk/pdbsum/6iwj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iwj ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Domain swapping is the process by which identical monomeric proteins exchange structural elements to generate dimers/oligomers. Although engineered domain swapping is a compelling strategy for protein assembly, its application has been limited due to the lack of simple and reliable design approaches. Here, we demonstrate that the hydrophobic five-residue 'cystatin motif' (QVVAG) from the domain-swapping protein Stefin B, when engineered into a solvent-exposed, tight surface loop between two beta-strands prevents the loop from folding back upon itself, and drives domain swapping in non-domain-swapping proteins. High-resolution structural studies demonstrate that engineering the QVVAG stretch independently into various surface loops of four structurally distinct non-domain-swapping proteins enabled the design of different modes of domain swapping in these proteins, including single, double and open-ended domain swapping. These results suggest that the introduction of the QVVAG motif can be used as a mutational approach for engineering domain swapping in diverse beta-hairpin proteins.

-	~~Authors~~:	+	A five-residue motif for the design of domain swapping in proteins.,Nandwani N, Surana P, Negi H, Mascarenhas NM, Udgaonkar JB, Das R, Gosavi S Nat Commun. 2019 Jan 28;10(1):452. doi: 10.1038/s41467-019-08295-x. PMID:30692525<ref>PMID:30692525</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6iwj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Das, R]]
		+	[[Category: Nandwani, N]]
		+	[[Category: Negi, H]]
		+	[[Category: Archea]]
		+	[[Category: Complex]]
		+	[[Category: Domain-swapping]]
		+	[[Category: Protein design]]
		+	[[Category: Unknown function]]

OCA at 06:37, 26 December 2018

OCA — Wed, 26 Dec 2018 06:37:02 GMT

←Older revision		Revision as of 06:37, 26 December 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6iwj is ON HOLD	+	The entry 6iwj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6iwj" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2018 05:15:29 GMT

Protected "6iwj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:15, 12 December 2018

OCA: New page: '''Unreleased structure''' The entry 6iwj is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Dec 2018 05:15:28 GMT

New page: '''Unreleased structure''' The entry 6iwj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6iwj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]