6j0q - Revision history

OCA at 09:56, 22 November 2023

OCA — Wed, 22 Nov 2023 09:56:58 GMT

←Older revision		Revision as of 09:56, 22 November 2023
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	<StructureSection load='6j0q' size='340' side='right'caption='[[6j0q]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6j0q' size='340' side='right'caption='[[6j0q]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6j0q]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Norovirus Norovirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6J0Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norwalk-like_virus_Sw/NLV/VA34/1998/NL Norwalk-like virus Sw/NLV/VA34/1998/NL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J0Q FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6j0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0q OCA], [~~http~~://pdbe.org/6j0q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6j0q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6j0q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0q ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0q OCA], [https://pdbe.org/6j0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j0q RCSB], [https://www.ebi.ac.uk/pdbsum/6j0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0q ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8QY02_9CALI Q8QY02_9CALI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Norovirus~~]]	+	[[Category: Norwalk-like virus Sw/NLV/VA34/1998/NL]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	~~[[Category: Capsid]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Hbga recognition]]~~	+
-	~~[[Category: Protruding domain]]~~	+
-	~~[[Category: Swine]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:43, 27 November 2019

OCA — Wed, 27 Nov 2019 08:43:18 GMT

←Older revision		Revision as of 08:43, 27 November 2019
Line 3:		Line 3:
	<StructureSection load='6j0q' size='340' side='right'caption='[[6j0q]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6j0q' size='340' side='right'caption='[[6j0q]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6j0q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J0Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j0q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus Norovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J0Q FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0q OCA], [http://pdbe.org/6j0q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j0q RCSB], [http://www.ebi.ac.uk/pdbsum/6j0q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0q ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0q OCA], [http://pdbe.org/6j0q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j0q RCSB], [http://www.ebi.ac.uk/pdbsum/6j0q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0q ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Diverse noroviruses infect humans and animals via the recognition of host-specific glycan ligands. Genogroup II (GII) noroviruses consist of human noroviruses (huNoVs) that generally bind histo-blood group antigens (HBGAs) as host factors and three porcine norovirus (porNoV) genotypes (GII.11/18/19) that form a genetic lineage lacking HBGA-binding ability. Thus, these GII porNoVs provide an excellent model to study norovirus evolution with host ligand specificity changes. Here we solved the crystal structures of a native GII.11 porNoV P protein and a closely-related GII.3 huNoV P protein complexed with an HBGA, focusing on the HBGA-binding sites (HBSs) compared with the previously known ones to understand the structural basis of the host ligand specificity change. We found that the GII.3 huNoV binds HBGAs via a conventional GII HBS that uses an arginine instead of the conserved aromatic residue for the required Van der Waals interaction, while the GII.11 porNoV HBS loses its HBGA-binding function because of two mutations (Q355/V451). A mutant that reversed the two mutated residues back to the conventional A355/Y451 restored the HBGA-binding function of the GII.11 porNoV P protein, which validated our observations. Similar mutations are also found in GII.19 porNoVs and a GII.19 P protein mutant with double reverse mutations restored the HBS function. This is the first reconstruction of a functional HBS based on one with new host specificity back to its parental one. These data shed light on the molecular basis of structural adaptation of the GII porNoVs to the pig hosts through mutations at their HBSs.
		+
		+	Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses.,Yang Y, Xia M, Wang L, Arumugam S, Wang Y, Ou X, Wang C, Jiang X, Tan M, Chen Y, Li X Emerg Microbes Infect. 2019;8(1):1642-1657. doi: 10.1080/22221751.2019.1686335. PMID:31711377<ref>PMID:31711377</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6j0q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Norovirus]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Capsid]]		[[Category: Capsid]]

OCA at 15:21, 20 November 2019

OCA — Wed, 20 Nov 2019 15:21:43 GMT

←Older revision		Revision as of 15:21, 20 November 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6j0q is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of P domain from GII.11 swine norovirus==
-		+	<StructureSection load='6j0q' size='340' side='right'caption='[[6j0q]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6j0q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J0Q FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0q OCA], [http://pdbe.org/6j0q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j0q RCSB], [http://www.ebi.ac.uk/pdbsum/6j0q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0q ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen, Y]]
		+	[[Category: Capsid]]
		+	[[Category: Dimer]]
		+	[[Category: Hbga recognition]]
		+	[[Category: Protruding domain]]
		+	[[Category: Swine]]
		+	[[Category: Viral protein]]

OCA at 06:23, 2 October 2019

OCA — Wed, 02 Oct 2019 06:23:57 GMT

←Older revision		Revision as of 06:23, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6j0q is ON HOLD	+	The entry 6j0q is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6j0q" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2019 04:51:11 GMT

Protected "6j0q" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:51, 2 January 2019

OCA: New page: '''Unreleased structure''' The entry 6j0q is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Jan 2019 04:51:09 GMT

New page: '''Unreleased structure''' The entry 6j0q is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6j0q is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]