6j55 - Revision history

OCA at 09:20, 20 March 2024

OCA — Wed, 20 Mar 2024 09:20:08 GMT

←Older revision		Revision as of 09:20, 20 March 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]		[https://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The iron superoxide dismutase found in the pathogenic amoeba Acanthamoeba castellanii (AcFeSOD) may play essential roles in the survival of the parasite, not only by protecting it from endogenous oxidative stress but also by detoxifying oxidative killing of the parasite by host immune effector cells. The AcFeSOD protein was expressed in a stable form using an Escherichia coli expression system and was crystallized by the microbatch and hanging-drop vapour-diffusion methods. The structure was determined to 2.33 A resolution from a single AcFeSOD crystal. The crystal belonged to the hexagonal space group P61 and contained 12 molecules forming three tetramers in the asymmetric unit, with an iron ion bound in each molecule. Structural comparisons and sequence alignment of AcFeSOD with other FeSODs showed a well conserved overall fold and conserved active-site residues with subtle differences.
-
-	Crystal structure of an iron superoxide dismutase from the pathogenic amoeba Acanthamoeba castellanii.,Dao O, Asaithambi K, Na BK, Lee KH Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):480-488. doi:, 10.1107/S2053230X19008112. Epub 2019 Jun 26. PMID:31282867<ref>PMID:31282867</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 6j55" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]		*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:59, 22 November 2023

OCA — Wed, 22 Nov 2023 09:59:51 GMT

←Older revision		Revision as of 09:59, 22 November 2023
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	<StructureSection load='6j55' size='340' side='right'caption='[[6j55]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='6j55' size='340' side='right'caption='[[6j55]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6j55]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Acaca Acaca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J55 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6J55 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j55]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J55 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=FE2:FE+(II)+ION'>FE2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.330005Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6j55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j55 OCA], [~~http~~://pdbe.org/6j55 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6j55 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6j55 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6j55 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j55 OCA], [https://pdbe.org/6j55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j55 RCSB], [https://www.ebi.ac.uk/pdbsum/6j55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j55 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]	+	[https://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6j55" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6j55" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acaca]]
-	[[Category: Large Structures]]
-	[[Category: Superoxide dismutase]]
-	[[Category: Asaithambi, K]]
-	[[Category: Dao, T O]]
-	[[Category: Lee, K H]]
-	[[Category: Na, B K]]
	[[Category: Acanthamoeba castellanii]]		[[Category: Acanthamoeba castellanii]]
-	[[Category: ~~Iron superoxide dismutase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Asaithambi K]]
		+	[[Category: Dao TO]]
		+	[[Category: Lee KH]]
		+	[[Category: Na BK]]

OCA at 17:28, 20 November 2019

OCA — Wed, 20 Nov 2019 17:28:40 GMT

←Older revision		Revision as of 17:28, 20 November 2019
Line 3:		Line 3:
	<StructureSection load='6j55' size='340' side='right'caption='[[6j55]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='6j55' size='340' side='right'caption='[[6j55]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6j55]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J55 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j55]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Acaca Acaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J55 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]		[[http://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The iron superoxide dismutase found in the pathogenic amoeba Acanthamoeba castellanii (AcFeSOD) may play essential roles in the survival of the parasite, not only by protecting it from endogenous oxidative stress but also by detoxifying oxidative killing of the parasite by host immune effector cells. The AcFeSOD protein was expressed in a stable form using an Escherichia coli expression system and was crystallized by the microbatch and hanging-drop vapour-diffusion methods. The structure was determined to 2.33 A resolution from a single AcFeSOD crystal. The crystal belonged to the hexagonal space group P61 and contained 12 molecules forming three tetramers in the asymmetric unit, with an iron ion bound in each molecule. Structural comparisons and sequence alignment of AcFeSOD with other FeSODs showed a well conserved overall fold and conserved active-site residues with subtle differences.
		+
		+	Crystal structure of an iron superoxide dismutase from the pathogenic amoeba Acanthamoeba castellanii.,Dao O, Asaithambi K, Na BK, Lee KH Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):480-488. doi:, 10.1107/S2053230X19008112. Epub 2019 Jun 26. PMID:31282867<ref>PMID:31282867</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6j55" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Acaca]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]

OCA at 10:40, 17 July 2019

OCA — Wed, 17 Jul 2019 10:40:16 GMT

←Older revision		Revision as of 10:40, 17 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6j55 is ~~ON HOLD~~	+	==Crystal structure of an iron superoxide dismutate (FeSOD) from a pathogenic Acanthamoeba castellanii==
-		+	<StructureSection load='6j55' size='340' side='right'caption='[[6j55]], [[Resolution\|resolution]] 2.33Å' scene=''>
-	~~Authors~~: ~~Lee~~, K.H., ~~Dao, T~~.O., ~~Asaithambi~~, K., Na, B.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6j55]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J55 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of an iron superoxide dismutate (FeSOD) from a pathogenic Acanthamoeba castellanii~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
-	[[Category: ~~Dao, T.O~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j55 OCA], [http://pdbe.org/6j55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j55 RCSB], [http://www.ebi.ac.uk/pdbsum/6j55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j55 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Superoxide dismutase]]
	[[Category: Asaithambi, K]]		[[Category: Asaithambi, K]]
-	[[Category: Na, ~~B.K~~]]	+	[[Category: Dao, T O]]
-	[[Category: Lee, K.H]]	+	[[Category: Lee, K H]]
		+	[[Category: Na, B K]]
		+	[[Category: Acanthamoeba castellanii]]
		+	[[Category: Iron superoxide dismutase]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "6j55" [edit=sysop:move=sysop]

OCA — Wed, 16 Jan 2019 10:28:17 GMT

Protected "6j55" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:28, 16 January 2019

OCA: New page: '''Unreleased structure''' The entry 6j55 is ON HOLD Authors: Lee, K.H., Dao, T.O., Asaithambi, K., Na, B.K. Description: Crystal structure of an iron superoxide dismutate (FeSOD) from...

OCA — Wed, 16 Jan 2019 10:28:15 GMT

New page: '''Unreleased structure''' The entry 6j55 is ON HOLD Authors: Lee, K.H., Dao, T.O., Asaithambi, K., Na, B.K. Description: Crystal structure of an iron superoxide dismutate (FeSOD) from...

New page

'''Unreleased structure'''

The entry 6j55 is ON HOLD

Authors: Lee, K.H., Dao, T.O., Asaithambi, K., Na, B.K.

Description: Crystal structure of an iron superoxide dismutate (FeSOD) from a pathogenic Acanthamoeba castellanii
[[Category: Unreleased Structures]]
[[Category: Dao, T.O]]
[[Category: Asaithambi, K]]
[[Category: Na, B.K]]
[[Category: Lee, K.H]]