6jah - Revision history

OCA at 10:05, 22 November 2023

OCA — Wed, 22 Nov 2023 10:05:28 GMT

←Older revision		Revision as of 10:05, 22 November 2023
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	<StructureSection load='6jah' size='340' side='right'caption='[[6jah]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='6jah' size='340' side='right'caption='[[6jah]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jah]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6JAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA6:(2S)-heptane-1,2,7-triol'>BA6</scene>, <scene name='pdbligand=BA9:propane-2,2-diol'>BA9</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHA0356 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA6:(2S)-heptane-1,2,7-triol'>BA6</scene>, <scene name='pdbligand=BA9:propane-2,2-diol'>BA9</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6jah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jah OCA], [~~http~~://pdbe.org/6jah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jah ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jah OCA], [https://pdbe.org/6jah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jah RCSB], [https://www.ebi.ac.uk/pdbsum/6jah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jah ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5SLD7_THET8 Q5SLD7_THET8]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thet8~~]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Chandravanshi, M]]	+	[[Category: Chandravanshi M]]
-	[[Category: Gogoi, P]]	+	[[Category: Gogoi P]]
-	[[Category: Kanaujia~~, S P]]~~	+	[[Category: Kanaujia SP]]
-	~~[[Category: Alpha-glycoside-binding protein]]~~	+
-	~~[[Category: Carbohydrate-bindingsite]]~~	+
-	~~[[Category: Ligand selection]]~~	+
-	~~[[Category: Multi-substrate transporter]]~~	+
-	~~[[Category: Sugar binding protein]]~~	+
-	~~[[Category: Sugar replacement]]~~	+
-	~~[[Category: Venus fly-trap mechanism~~]]	+

OCA at 06:21, 6 May 2020

OCA — Wed, 06 May 2020 06:21:52 GMT

←Older revision		Revision as of 06:21, 6 May 2020
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	<StructureSection load='6jah' size='340' side='right'caption='[[6jah]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='6jah' size='340' side='right'caption='[[6jah]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JAH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JAH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA6:(2S)-heptane-1,2,7-triol'>BA6</scene>, <scene name='pdbligand=BA9:propane-2,2-diol'>BA9</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA6:(2S)-heptane-1,2,7-triol'>BA6</scene>, <scene name='pdbligand=BA9:propane-2,2-diol'>BA9</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jah OCA], [http://pdbe.org/6jah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jah RCSB], [http://www.ebi.ac.uk/pdbsum/6jah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jah ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHA0356 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jah OCA], [http://pdbe.org/6jah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jah RCSB], [http://www.ebi.ac.uk/pdbsum/6jah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jah ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Thet8]]
	[[Category: Chandravanshi, M]]		[[Category: Chandravanshi, M]]
	[[Category: Gogoi, P]]		[[Category: Gogoi, P]]

OCA at 09:02, 30 October 2019

OCA — Wed, 30 Oct 2019 09:02:01 GMT

←Older revision		Revision as of 09:02, 30 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6jah is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of ABC transporter alpha-glycoside-binding protein in complex with glucose==
		+	<StructureSection load='6jah' size='340' side='right'caption='[[6jah]], [[Resolution\|resolution]] 1.63Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JAH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA6:(2S)-heptane-1,2,7-triol'>BA6</scene>, <scene name='pdbligand=BA9:propane-2,2-diol'>BA9</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jah OCA], [http://pdbe.org/6jah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jah RCSB], [http://www.ebi.ac.uk/pdbsum/6jah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jah ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carbohydrate (or sugar) molecules are extremely diverse regarding their length, linkage and epimeric state. Selective acquisition of these molecules inside the cell is achieved by the substrate (or solute)-binding protein of ATP-binding cassette (ABC) transport system. However, the molecular mechanism underlying the selective transport of diverse carbohydrates remains unclear mainly owing to their structural complexity and stereochemistry. This study reports crystal structures of an alpha-glycoside-binding protein (alphaGlyBP, ORF ID: TTHA0356 from Thermus thermophilus HB8) in complex with disaccharide alpha-glycosides namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose within a resolution range of 1.6 to 2.0 A. Despite transporting multiple types of sugars, alphaGlyBP maintains its stereoselectivity for both glycosidic linkage as well as an epimeric hydroxyl group. Out of the two subsites identified in the active-site pocket, subsite B which accommodates the glucose and glycosyl unit of disaccharide alpha-glycosides is highly conserved. In addition, structural data confirms the paradoxical behavior of glucose, where it replaces the high-affinity ligand(s) (disaccharide alpha-glycosides) from the active site of the protein. Comparative assessment of open and closed conformations of alphaGlyBP along with mutagenic and thermodynamic studies identifies the hinge region as the first interaction site for the ligands. On the other hand, encapsulation of ligand inside the active site is achieved through the N-terminal domain (NTD) movement, whereas the C-terminal domain (CTD) of alphaGlyBP is identified to be rigid and postulated to be responsible for maintaining the interaction with the transmembrane domain (TMD) during substrate translocation.

-	~~Authors~~:	+	Structural and thermodynamic correlation illuminates the selective transport mechanism of disaccharide alpha-glycosides through ABC transporter.,Chandravanshi M, Gogoi P, Kanaujia SP FEBS J. 2019 Oct 14. doi: 10.1111/febs.15093. PMID:31608555<ref>PMID:31608555</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6jah" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chandravanshi, M]]
		+	[[Category: Gogoi, P]]
		+	[[Category: Kanaujia, S P]]
		+	[[Category: Alpha-glycoside-binding protein]]
		+	[[Category: Carbohydrate-bindingsite]]
		+	[[Category: Ligand selection]]
		+	[[Category: Multi-substrate transporter]]
		+	[[Category: Sugar binding protein]]
		+	[[Category: Sugar replacement]]
		+	[[Category: Venus fly-trap mechanism]]

OCA at 05:23, 6 March 2019

OCA — Wed, 06 Mar 2019 05:23:56 GMT

←Older revision		Revision as of 05:23, 6 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jah is ON HOLD	+	The entry 6jah is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 07:17, 13 February 2019

OCA — Wed, 13 Feb 2019 07:17:41 GMT

←Older revision		Revision as of 07:17, 13 February 2019
Line 3:		Line 3:
	The entry 6jah is ON HOLD		The entry 6jah is ON HOLD

-	Authors: ~~Kanaujia, S.P., Chandravanshi, M., Gogoi, P.~~	+	Authors:

-	Description: ~~Crystal structure of ABC transporter alpha-glycoside-binding protein in complex with glucose~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Chandravanshi, M]]
-	[[Category: Gogoi, P]]
-	[[Category: Kanaujia, S.P]]

OCA: Protected "6jah" [edit=sysop:move=sysop]

OCA — Wed, 30 Jan 2019 06:20:01 GMT

Protected "6jah" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:20, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6jah is ON HOLD Authors: Kanaujia, S.P., Chandravanshi, M., Gogoi, P. Description: Crystal structure of ABC transporter alpha-glycoside-binding pro...

OCA — Wed, 30 Jan 2019 06:19:59 GMT

New page: '''Unreleased structure''' The entry 6jah is ON HOLD Authors: Kanaujia, S.P., Chandravanshi, M., Gogoi, P. Description: Crystal structure of ABC transporter alpha-glycoside-binding pro...

New page

'''Unreleased structure'''

The entry 6jah is ON HOLD

Authors: Kanaujia, S.P., Chandravanshi, M., Gogoi, P.

Description: Crystal structure of ABC transporter alpha-glycoside-binding protein in complex with glucose
[[Category: Unreleased Structures]]
[[Category: Chandravanshi, M]]
[[Category: Gogoi, P]]
[[Category: Kanaujia, S.P]]