6jbx - Revision history

OCA at 10:37, 27 March 2024

OCA — Wed, 27 Mar 2024 10:37:33 GMT

←Older revision		Revision as of 10:37, 27 March 2024
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	<StructureSection load='6jbx' size='340' side='right'caption='[[6jbx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6jbx' size='340' side='right'caption='[[6jbx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jbx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jbx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JBX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=TRD:TRIDECANE'>TRD</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>marR_1, fabT, marR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1313~~ "~~Diplococcus pneumoniae~~" ~~(Klein 1884) Weichselbaum 1886])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRD:TRIDECANE'>TRD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbx OCA], [~~http~~://pdbe.org/6jbx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jbx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jbx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbx OCA], [https://pdbe.org/6jbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jbx RCSB], [https://www.ebi.ac.uk/pdbsum/6jbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbx ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q8DR18_STRR6 Q8DR18_STRR6]
-	The Streptococcus pneumoniae fatty acid synthesis pathway is globally controlled at the transcriptional level by the repressor FabT and its co-repressor acyl carrier protein (acyl-ACP), the intermediate of phospholipid synthesis. Here, we report the crystal structure of FabT complexed with a 23-bp dsDNA, which indicates that FabT is a weak repressor with low DNA-binding affinity in the absence of acyl-ACP. Modification of ACP with a long-chain fatty acid is necessary for the formation of a stable complex with FabT, mimicked in vitro by cross-linking, which significantly elevates the DNA-binding affinity of FabT. Altogether, we propose a putative working model of gene repression under the double control of FabT and acyl-ACP, elucidating a distinct repression network for Pneumococcus to precisely coordinate fatty acid synthesis. This article is protected by copyright. All rights reserved.	+
-		+
-	Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co-repressor acyl-ACP.,Zuo G, Chen ZP, Jiang YL, Zhu Z, Ding C, Zhang Z, Chen Y, Zhou CZ, Li Q FEBS Lett. 2019 Jul 10. doi: ~~10.1002~~/~~1873-3468.13534. PMID:31291684<ref>PMID:31291684<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6jbx" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, Z P~~]]	+	[[Category: Streptococcus pneumoniae]]
-	[[Category: ~~Li, Q~~]]	+	[[Category: Chen ZP]]
-	[[Category: ~~Zhou, C Z~~]]	+	[[Category: Li Q]]
-	[[Category: ~~Zuo, G~~]]	+	[[Category: Zhou CZ]]
-	[[Category: ~~Fatty acid synthesis]]~~	+	[[Category: Zuo G]]
-	~~[[Category: Marr family]]~~	+
-	~~[[Category: Transcription factor]]~~	+
-	~~[[Category: Transcription-dna complex~~]]	+

OCA at 07:55, 23 October 2019

OCA — Wed, 23 Oct 2019 07:55:41 GMT

←Older revision		Revision as of 07:55, 23 October 2019
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	<StructureSection load='6jbx' size='340' side='right'caption='[[6jbx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6jbx' size='340' side='right'caption='[[6jbx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jbx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jbx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JBX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRD:TRIDECANE'>TRD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRD:TRIDECANE'>TRD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">marR_1, fabT, marR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbx OCA], [http://pdbe.org/6jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jbx RCSB], [http://www.ebi.ac.uk/pdbsum/6jbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbx OCA], [http://pdbe.org/6jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jbx RCSB], [http://www.ebi.ac.uk/pdbsum/6jbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:13, 24 July 2019

OCA — Wed, 24 Jul 2019 06:13:02 GMT

←Older revision		Revision as of 06:13, 24 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6jbx is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Streptococcus pneumoniae FabT in complex with DNA==
		+	<StructureSection load='6jbx' size='340' side='right'caption='[[6jbx]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jbx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JBX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRD:TRIDECANE'>TRD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbx OCA], [http://pdbe.org/6jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jbx RCSB], [http://www.ebi.ac.uk/pdbsum/6jbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbx ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Streptococcus pneumoniae fatty acid synthesis pathway is globally controlled at the transcriptional level by the repressor FabT and its co-repressor acyl carrier protein (acyl-ACP), the intermediate of phospholipid synthesis. Here, we report the crystal structure of FabT complexed with a 23-bp dsDNA, which indicates that FabT is a weak repressor with low DNA-binding affinity in the absence of acyl-ACP. Modification of ACP with a long-chain fatty acid is necessary for the formation of a stable complex with FabT, mimicked in vitro by cross-linking, which significantly elevates the DNA-binding affinity of FabT. Altogether, we propose a putative working model of gene repression under the double control of FabT and acyl-ACP, elucidating a distinct repression network for Pneumococcus to precisely coordinate fatty acid synthesis. This article is protected by copyright. All rights reserved.

-	~~Authors~~:	+	Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co-repressor acyl-ACP.,Zuo G, Chen ZP, Jiang YL, Zhu Z, Ding C, Zhang Z, Chen Y, Zhou CZ, Li Q FEBS Lett. 2019 Jul 10. doi: 10.1002/1873-3468.13534. PMID:31291684<ref>PMID:31291684</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6jbx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen, Z P]]
		+	[[Category: Li, Q]]
		+	[[Category: Zhou, C Z]]
		+	[[Category: Zuo, G]]
		+	[[Category: Fatty acid synthesis]]
		+	[[Category: Marr family]]
		+	[[Category: Transcription factor]]
		+	[[Category: Transcription-dna complex]]

OCA at 05:17, 10 April 2019

OCA — Wed, 10 Apr 2019 05:17:19 GMT

←Older revision		Revision as of 05:17, 10 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jbx is ON HOLD	+	The entry 6jbx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6jbx" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2019 07:20:12 GMT

Protected "6jbx" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 13 February 2019

OCA: New page: '''Unreleased structure''' The entry 6jbx is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Feb 2019 07:20:10 GMT

New page: '''Unreleased structure''' The entry 6jbx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6jbx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]