6jdi - Revision history

OCA at 10:06, 22 November 2023

OCA — Wed, 22 Nov 2023 10:06:54 GMT

←Older revision		Revision as of 10:06, 22 November 2023
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	<StructureSection load='6jdi' size='340' side='right'caption='[[6jdi]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='6jdi' size='340' side='right'caption='[[6jdi]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jdi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JDI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JDI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jdi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JDI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jdi OCA], [~~http~~://pdbe.org/6jdi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jdi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jdi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jdi ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jdi OCA], [https://pdbe.org/6jdi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jdi RCSB], [https://www.ebi.ac.uk/pdbsum/6jdi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jdi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FLEQ_PSEAE FLEQ_PSEAE] AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression (PubMed:9287015, PubMed:11673434, PubMed:26362077). In addition to flagella genes, regulates also expression of biofilm-related genes (PubMed:22581773). Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present (PubMed:22581773).<ref>PMID:11673434</ref> <ref>PMID:22581773</ref> <ref>PMID:26362077</ref> <ref>PMID:9287015</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Banerjee, P]]	+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Banerjee P]]
	[[Category: Chanchal]]		[[Category: Chanchal]]
-	[[Category: Jain, D]]	+	[[Category: Jain D]]
-	~~[[Category: Aaa+]]~~	+
-	~~[[Category: Fleq]]~~	+
-	~~[[Category: Ntrc]]~~	+
-	~~[[Category: Pseudomona]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 06:46, 27 November 2019

OCA — Wed, 27 Nov 2019 06:46:45 GMT

←Older revision		Revision as of 06:46, 27 November 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6jdi is ~~ON HOLD until Paper~~ Publication	+	==Central domain of FleQ H287N mutant in complex with ATPgS and Mg==
		+	<StructureSection load='6jdi' size='340' side='right'caption='[[6jdi]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jdi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JDI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jdi OCA], [http://pdbe.org/6jdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jdi RCSB], [http://www.ebi.ac.uk/pdbsum/6jdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jdi ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the AAA+ (ATPase associated with various cellular activities) family of ATPases couple chemical energy derived from ATP hydrolysis for generation of mechanical force, resulting in conformational changes. The hydrolysis is brought about by highly conserved domains and motifs. The sensor I motif is critical for sensing and hydrolysis of the nucleotide. Pseudomonas aeruginosa FleQ is an ATPase that is a positive regulator of flagellar gene expression. We have determined the crystal structures of the ATPase domain of wild-type FleQ and sensor I mutants H287N and H287A in complex with ATPgammaS and Mg(2+) to 2.4, 1.95, and 2.25 A resolution, respectively. The structural data highlight the role of sensor I in regulating the ATPase activity. The in vitro and in vivo data demonstrate that the moderate ATPase activity of FleQ due to the presence of histidine in sensor I is essential for maintaining the monotrichous phenotype and for the rapid motility to biofilm transition.

-	~~Authors: Jain, D~~., Banerjee, P., Chanchal	+	Sensor I Regulated ATPase Activity of FleQ Is Essential for Motility to Biofilm Transition in Pseudomonas aeruginosa.,Banerjee P, Chanchal, Jain D ACS Chem Biol. 2019 Jul 19;14(7):1515-1527. doi: 10.1021/acschembio.9b00255. Epub, 2019 Jul 3. PMID:31268665<ref>PMID:31268665</ref>

-	~~Description: Central domain~~ of ~~FleQ H287N mutant in complex with ATPgS and Mg~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Chanchal~~]]	+	<div class="pdbe-citations 6jdi" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Banerjee, P]]		[[Category: Banerjee, P]]
		+	[[Category: Chanchal]]
	[[Category: Jain, D]]		[[Category: Jain, D]]
		+	[[Category: Aaa+]]
		+	[[Category: Fleq]]
		+	[[Category: Ntrc]]
		+	[[Category: Pseudomona]]
		+	[[Category: Transcription]]

OCA at 05:17, 10 April 2019

OCA — Wed, 10 Apr 2019 05:17:22 GMT

←Older revision		Revision as of 05:17, 10 April 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jdi is ON HOLD	+	The entry 6jdi is ON HOLD until Paper Publication

	Authors: Jain, D., Banerjee, P., Chanchal		Authors: Jain, D., Banerjee, P., Chanchal
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Chanchal]]		[[Category: Chanchal]]
-	[[Category: Jain, D]]
	[[Category: Banerjee, P]]		[[Category: Banerjee, P]]
		+	[[Category: Jain, D]]

OCA: Protected "6jdi" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2019 07:24:56 GMT

Protected "6jdi" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:24, 13 February 2019

OCA: New page: '''Unreleased structure''' The entry 6jdi is ON HOLD Authors: Jain, D., Banerjee, P., Chanchal Description: Central domain of FleQ H287N mutant in complex with ATPgS and Mg [[Category:...

OCA — Wed, 13 Feb 2019 07:24:55 GMT

New page: '''Unreleased structure''' The entry 6jdi is ON HOLD Authors: Jain, D., Banerjee, P., Chanchal Description: Central domain of FleQ H287N mutant in complex with ATPgS and Mg [[Category:...

New page

'''Unreleased structure'''

The entry 6jdi is ON HOLD

Authors: Jain, D., Banerjee, P., Chanchal

Description: Central domain of FleQ H287N mutant in complex with ATPgS and Mg
[[Category: Unreleased Structures]]
[[Category: Chanchal]]
[[Category: Jain, D]]
[[Category: Banerjee, P]]