6jhy - Revision history

OCA at 10:09, 22 November 2023

OCA — Wed, 22 Nov 2023 10:09:44 GMT

←Older revision		Revision as of 10:09, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='6jhy' size='340' side='right'caption='[[6jhy]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6jhy' size='340' side='right'caption='[[6jhy]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jhy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JHY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JHY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jhy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dromedary_camel_coronavirus_HKU23 Dromedary camel coronavirus HKU23]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JHY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jhy OCA], [~~http~~://pdbe.org/6jhy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jhy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jhy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jhy ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jhy OCA], [https://pdbe.org/6jhy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jhy RCSB], [https://www.ebi.ac.uk/pdbsum/6jhy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jhy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/X2JHN8_9BETC X2JHN8_9BETC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6jhy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6jhy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sandbox 3001\|Sandbox 3001]]
		+	*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dromedary camel coronavirus HKU23]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cheng, Y]]	+	[[Category: Cheng Y]]
-	[[Category: Lu, G]]	+	[[Category: Lu G]]
-	[[Category: Ye, F]]	+	[[Category: Ye F]]
-	~~[[Category: Crystal structure]]~~	+
-	~~[[Category: Dccov uae-hku23]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 06:13, 24 July 2019

OCA — Wed, 24 Jul 2019 06:13:30 GMT

←Older revision		Revision as of 06:13, 24 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6jhy is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of the S1 subunit N-terminal domain from DcCoV UAE-HKU23 spike protein==
		+	<StructureSection load='6jhy' size='340' side='right'caption='[[6jhy]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jhy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JHY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jhy OCA], [http://pdbe.org/6jhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jhy RCSB], [http://www.ebi.ac.uk/pdbsum/6jhy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jhy ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The DcCoV UAE-HKU23 coronavirus is a newly-found betacoronavirus (betaCoV) that can infect human cells. The viral spike protein plays pivotal roles in mediating receptor-recognition and membrane-fusion, and is therefore a key factor involved in viral pathogenesis and inter-species transmission. Here we reported the structural and functional characterization of the spike N-terminal domain (NTD) from DcCoV UAE-HKU23 (HKU23-NTD). Via mucin-binding assays, we showed that HKU23-NTD is able to bind sugars. We further solved the structure of HKU23-NTD, performed structure-guided mutagenesis and successfully located the potential sugar-binding pockets in the structure. Furthermore, via comparison of available betaCoV NTD structures, we demonstrated that betaCoV NTDs contain a conserved beta-sandwich core, but exhibit variant folds in the peripheral elements located in the top-ceiling region and on the lateral side. While showing different compositions and structures, these peripheral elements are topologically equivalent beta-sandwich-core insertions, highlighting a divergent evolution process for betaCoVs to form different lineages.

-	~~Authors~~:	+	Crystal structure of the S1 subunit N-terminal domain from DcCoV UAE-HKU23 spike protein.,Cheng Y, He B, Yang J, Ye F, Lin S, Yang F, Chen Z, Chen Z, Cao Y, Lu G Virology. 2019 Jun 27;535:74-82. doi: 10.1016/j.virol.2019.06.015. PMID:31279241<ref>PMID:31279241</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6jhy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cheng, Y]]
		+	[[Category: Lu, G]]
		+	[[Category: Ye, F]]
		+	[[Category: Crystal structure]]
		+	[[Category: Dccov uae-hku23]]
		+	[[Category: Viral protein]]

OCA at 04:41, 24 April 2019

OCA — Wed, 24 Apr 2019 04:41:19 GMT

←Older revision		Revision as of 04:41, 24 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jhy is ON HOLD	+	The entry 6jhy is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6jhy" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2019 13:38:10 GMT

Protected "6jhy" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:38, 27 February 2019

OCA: New page: '''Unreleased structure''' The entry 6jhy is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Feb 2019 13:38:09 GMT

New page: '''Unreleased structure''' The entry 6jhy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6jhy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]