OCA at 10:11, 22 November 2023

OCA — Wed, 22 Nov 2023 10:11:37 GMT

←Older revision		Revision as of 10:11, 22 November 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 6jjy is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of KIBRA and beta-Dystroglycan==
		+	<StructureSection load='6jjy' size='340' side='right'caption='[[6jjy]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jjy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JJY FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.298Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jjy OCA], [https://pdbe.org/6jjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jjy RCSB], [https://www.ebi.ac.uk/pdbsum/6jjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jjy ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KIBRA_MOUSE KIBRA_MOUSE] Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade.<ref>PMID:18190796</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain proteins in cell growth regulation. Here, we discovered that WW domain tandems of KIBRA and MAGI, but not YAP, bind to specific target proteins with extremely high affinity and exquisite sequence specificity. Via systematic structural biology and biochemistry approaches, we decoded the target binding rules of WW domain tandems from cell growth regulatory proteins and uncovered a list of previously unknown WW tandem binding proteins including beta-Dystroglycan, JCAD, and PTPN21. The WW tandem-mediated target recognition mechanisms elucidated here can guide functional studies of WW domain proteins in cell growth and polarity as well as in other cellular processes including neuronal synaptic signaling.

-	~~Authors: Lin~~, Z., Yang, Z., Ji, Z., ~~Zhang~~, M.	+	Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.,Lin Z, Yang Z, Xie R, Ji Z, Guan K, Zhang M Elife. 2019 Sep 5;8:e49439. doi: 10.7554/eLife.49439. PMID:31486770<ref>PMID:31486770</ref>

-	~~Description: Crystal Structure~~ of ~~KIBRA and beta~~-~~Dystroglycan~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Zhang, M~~]]	+	<div class="pdbe-citations 6jjy" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Yang,~~ Z]]	+	== References ==
-	[[Category: Lin, Z]]	+	<references/>
-	[[Category: ~~Ji,~~ Z]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Ji Z]]
		+	[[Category: Lin Z]]
		+	[[Category: Yang Z]]
		+	[[Category: Zhang M]]

OCA at 05:49, 20 March 2019

OCA — Wed, 20 Mar 2019 05:49:23 GMT

←Older revision		Revision as of 05:49, 20 March 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jjy is ON HOLD	+	The entry 6jjy is ON HOLD until Paper Publication

	Authors: Lin, Z., Yang, Z., Ji, Z., Zhang, M.		Authors: Lin, Z., Yang, Z., Ji, Z., Zhang, M.

OCA: Protected "6jjy" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2019 05:32:01 GMT

Protected "6jjy" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:32, 6 March 2019

OCA: New page: '''Unreleased structure''' The entry 6jjy is ON HOLD Authors: Lin, Z., Yang, Z., Ji, Z., Zhang, M. Description: Crystal Structure of KIBRA and beta-Dystroglycan [[Category: Unreleased ...

OCA — Wed, 06 Mar 2019 05:31:59 GMT

New page: '''Unreleased structure''' The entry 6jjy is ON HOLD Authors: Lin, Z., Yang, Z., Ji, Z., Zhang, M. Description: Crystal Structure of KIBRA and beta-Dystroglycan [[Category: Unreleased ...

New page

'''Unreleased structure'''

The entry 6jjy is ON HOLD

Authors: Lin, Z., Yang, Z., Ji, Z., Zhang, M.

Description: Crystal Structure of KIBRA and beta-Dystroglycan
[[Category: Unreleased Structures]]
[[Category: Zhang, M]]
[[Category: Yang, Z]]
[[Category: Lin, Z]]
[[Category: Ji, Z]]

6jjy - Revision history

OCA at 10:11, 22 November 2023

OCA at 05:49, 20 March 2019

OCA: Protected "6jjy" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6jjy is ON HOLD Authors: Lin, Z., Yang, Z., Ji, Z., Zhang, M. Description: Crystal Structure of KIBRA and beta-Dystroglycan [[Category: Unreleased ...