6jkm - Revision history

OCA at 10:13, 22 November 2023

OCA — Wed, 22 Nov 2023 10:13:39 GMT

←Older revision		Revision as of 10:13, 22 November 2023
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	<StructureSection load='6jkm' size='340' side='right'caption='[[6jkm]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='6jkm' size='340' side='right'caption='[[6jkm]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jkm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JKM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JKM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BubR1, Bub1, CG7838 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkm OCA], [~~http~~://pdbe.org/6jkm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jkm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jkm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkm OCA], [https://pdbe.org/6jkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jkm RCSB], [https://www.ebi.ac.uk/pdbsum/6jkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A1Z6I7_DROME A1Z6I7_DROME]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6jkm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6jkm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang, Y]]	+	[[Category: Huang Y]]
-	[[Category: Lin, L]]	+	[[Category: Lin L]]
-	[[Category: Liu, X]]	+	[[Category: Liu X]]
-	[[Category: Yao, X]]	+	[[Category: Yao X]]
-	[[Category: Ye, S]]	+	[[Category: Ye S]]
-	[[Category: Zhang, R]]	+	[[Category: Zhang R]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Mitotic checkpoint]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:35, 17 July 2019

OCA — Wed, 17 Jul 2019 12:35:16 GMT

←Older revision		Revision as of 12:35, 17 July 2019
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	<StructureSection load='6jkm' size='340' side='right'caption='[[6jkm]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='6jkm' size='340' side='right'caption='[[6jkm]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jkm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JKM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jkm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JKM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BubR1, Bub1, CG7838 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkm OCA], [http://pdbe.org/6jkm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jkm RCSB], [http://www.ebi.ac.uk/pdbsum/6jkm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkm OCA], [http://pdbe.org/6jkm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jkm RCSB], [http://www.ebi.ac.uk/pdbsum/6jkm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkm ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Huang, Y]]		[[Category: Huang, Y]]

OCA at 06:53, 26 June 2019

OCA — Wed, 26 Jun 2019 06:53:26 GMT

←Older revision		Revision as of 06:53, 26 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6jkm is ~~ON HOLD~~	+	==Crystal structure of BubR1 kinase domain==
		+	<StructureSection load='6jkm' size='340' side='right'caption='[[6jkm]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jkm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JKM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkm OCA], [http://pdbe.org/6jkm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jkm RCSB], [http://www.ebi.ac.uk/pdbsum/6jkm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkm ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the alphaN1 helix of N-terminal extension and alphaC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays.

-	~~Authors~~:	+	BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules.,Huang Y, Lin L, Liu X, Ye S, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R, Yao X Cell Res. 2019 Jun 14. pii: 10.1038/s41422-019-0178-z. doi:, 10.1038/s41422-019-0178-z. PMID:31201382<ref>PMID:31201382</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6jkm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Huang, Y]]
		+	[[Category: Lin, L]]
		+	[[Category: Liu, X]]
		+	[[Category: Yao, X]]
		+	[[Category: Ye, S]]
		+	[[Category: Zhang, R]]
		+	[[Category: Kinase]]
		+	[[Category: Mitotic checkpoint]]
		+	[[Category: Transferase]]

OCA: Protected "6jkm" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2019 05:35:06 GMT

Protected "6jkm" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:35, 6 March 2019

OCA: New page: '''Unreleased structure''' The entry 6jkm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Mar 2019 05:35:04 GMT

New page: '''Unreleased structure''' The entry 6jkm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6jkm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]