6jlc - Revision history

OCA at 10:14, 22 November 2023

OCA — Wed, 22 Nov 2023 10:14:33 GMT

←Older revision		Revision as of 10:14, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='6jlc' size='340' side='right'caption='[[6jlc]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='6jlc' size='340' side='right'caption='[[6jlc]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jlc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Falcivibrio_vaginalis Falcivibrio vaginalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6JLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jlc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mobiluncus_curtisii_ATCC_43063 Mobiluncus curtisii ATCC 43063]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JLC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.847Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HMPREF0573_10472 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=548479 Falcivibrio vaginalis])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6jlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jlc OCA], [~~http~~://pdbe.org/6jlc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jlc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jlc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jlc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jlc OCA], [https://pdbe.org/6jlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jlc RCSB], [https://www.ebi.ac.uk/pdbsum/6jlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jlc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D6ZJ92_MOBCV D6ZJ92_MOBCV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Falcivibrio vaginalis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Jin, T C]]~~	+	[[Category: Mobiluncus curtisii ATCC 43063]]
-	~~[[Category: Zeng, W H]]~~	+	[[Category: Jin TC]]
-	~~[[Category: Bacterial vaginosis]]~~	+	[[Category: Zeng WH]]
-	~~[[Category: Hemolytic reaction]]~~	+
-	[[Category: Mobiluncus curtisii]]	+
-	[[Category: ~~Pore-forming-factor~~]]	+
-	[[Category: ~~Toxin~~]]	+

OCA at 07:15, 8 April 2020

OCA — Wed, 08 Apr 2020 07:15:57 GMT

←Older revision		Revision as of 07:15, 8 April 2020
Line 3:		Line 3:
	<StructureSection load='6jlc' size='340' side='right'caption='[[6jlc]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='6jlc' size='340' side='right'caption='[[6jlc]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jlc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jlc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Falcivibrio_vaginalis Falcivibrio vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JLC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jlc OCA], [http://pdbe.org/6jlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jlc RCSB], [http://www.ebi.ac.uk/pdbsum/6jlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jlc ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HMPREF0573_10472 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=548479 Falcivibrio vaginalis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jlc OCA], [http://pdbe.org/6jlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jlc RCSB], [http://www.ebi.ac.uk/pdbsum/6jlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jlc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Falcivibrio vaginalis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Jin, T C]]		[[Category: Jin, T C]]

OCA at 08:04, 4 December 2019

OCA — Wed, 04 Dec 2019 08:04:49 GMT

←Older revision		Revision as of 08:04, 4 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6jlc is ~~ON HOLD until Mar 04 2021~~	+	==Structure determination of CAMP factor of Mobiluncus curtisii and insight into structural dynamics==
		+	<StructureSection load='6jlc' size='340' side='right'caption='[[6jlc]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jlc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JLC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jlc OCA], [http://pdbe.org/6jlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jlc RCSB], [http://www.ebi.ac.uk/pdbsum/6jlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jlc ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial vaginosis (BV) is a common type of vaginal inflammation caused by a proliferation of pathogenic bacteria, among which Mobiluncus curtisii. In our previous studies on M. curtisii genome, we identified the presence of a genomic fragment encoding a 25 kDa pore-forming toxin, the CAMP factor, which is known to be involved in the synergistic lysis of erythrocytes namely CAMP reaction. However, whether this hypothetical gene product has hemolytic activity is unknown. Moreover, its relative structure and function are not yet solved. Here we found that the M. curtisii CAMP factor is a monomer at pH 4.4 and oligomer at pH >4.6. Hemolysis assays showed that M. curtisii CAMP factor could lyse sheep red blood cells efficiently in pH 5.4-7.4. Negative staining electron microscope analysis of the CAMP factor revealed ring-like structures at pH above 4.6. Additionally, the crystal structure of M. curtisii CAMP factor, determineded at 1.85 A resolution, reveals a 5 + 3 helix motif. Further functional analysis suggested that the structural rearrangement of the N-terminal domain might be required for protein function. In conclusion, this structure-function relationship study of CAMP factor provides a new perspective of the M. curtisii role in BV development.

-	~~Authors~~:	+	Structure determination of CAMP factor of Mobiluncus curtisii and insights into structural dynamics.,Zeng W, Ma H, Fan W, Yang Y, Zhang C, Arnaud Kombe Kombe J, Fan X, Zhang Y, Dong Z, Shen Z, Zhou Y, Yang M, Jin T Int J Biol Macromol. 2019 Nov 15. pii: S0141-8130(19)37284-8. doi:, 10.1016/j.ijbiomac.2019.10.107. PMID:31739050<ref>PMID:31739050</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6jlc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Jin, T C]]
		+	[[Category: Zeng, W H]]
		+	[[Category: Bacterial vaginosis]]
		+	[[Category: Hemolytic reaction]]
		+	[[Category: Mobiluncus curtisii]]
		+	[[Category: Pore-forming-factor]]
		+	[[Category: Toxin]]

OCA at 04:15, 29 May 2019

OCA — Wed, 29 May 2019 04:15:42 GMT

←Older revision		Revision as of 04:15, 29 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jlc is ON HOLD	+	The entry 6jlc is ON HOLD until Mar 04 2021

	Authors:		Authors:

OCA: Protected "6jlc" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2019 10:02:51 GMT

Protected "6jlc" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:02, 13 March 2019

OCA: New page: '''Unreleased structure''' The entry 6jlc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Mar 2019 10:02:49 GMT

New page: '''Unreleased structure''' The entry 6jlc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6jlc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]