6jnp - Revision history

OCA at 10:16, 22 November 2023

OCA — Wed, 22 Nov 2023 10:16:39 GMT

←Older revision		Revision as of 10:16, 22 November 2023
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	<StructureSection load='6jnp' size='340' side='right'caption='[[6jnp]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='6jnp' size='340' side='right'caption='[[6jnp]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jnp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JNP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JNP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jnp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JNP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.261Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jnp OCA], [~~http~~://pdbe.org/6jnp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jnp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jnp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jnp ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jnp OCA], [https://pdbe.org/6jnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jnp RCSB], [https://www.ebi.ac.uk/pdbsum/6jnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jnp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EXOT_PSEAE EXOT_PSEAE] Bifunctional effector protein that is secreted and delivered by the type III secretion system into eukaryotic target cells. The N-terminus encodes a GTPase-activating protein activity, whereas the C-terminus encodes an ADP-ribosyltransferase activity (PubMed:11298647). ADP-ribosylates several eukaryotic proteins including CT10 regulator of kinase (Crk) proteins (PubMed:12807879). In turn, induces atypical anoikis apoptosis by transforming Crk adaptor protein into a cytotoxin (PubMed:26020630). Affects host cell morphology by disrupting the actin cytoskeleton (PubMed:14688136). In addition to this activity, acts via its N-terminal region as a GTPase-activating protein (GAP) for host Rho GTPases including RhoA, Rac1, Cdc42 and Ras (PubMed:11895987). The GAP domain activity induces mitochondrial disruption in the target host cell by activating host caspases 3 and 9 that execute cellular death (PubMed:26451042). This activity also causes stress fiber disassembly (PubMed:11895987).<ref>PMID:11298647</ref> <ref>PMID:11895987</ref> <ref>PMID:12807879</ref> <ref>PMID:14688136</ref> <ref>PMID:26020630</ref> <ref>PMID:26451042</ref>
		+
		+	==See Also==
		+	*[[Exoenzyme 3D structures\|Exoenzyme 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Datta, S]]
-	[[Category: Mondal, A]]
-	[[Category: Chaperone]]
-	[[Category: Effector]]
-	[[Category: Effector-toxin]]
-	[[Category: Exot]]
-	[[Category: Exotoxin]]
-	[[Category: Pseudomona]]
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
-	[[Category: ~~Spc~~]]	+	[[Category: Datta S]]
-	[[Category: ~~T3ss]]~~	+	[[Category: Mondal A]]
-	~~[[Category: Toxin~~]]	+

OCA at 07:05, 3 April 2019

OCA — Wed, 03 Apr 2019 07:05:15 GMT

←Older revision		Revision as of 07:05, 3 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6jnp is ON HOLD~~	+	==Structure of ExoT-SpcS Complex from Pseudomonas aeruginosa in 2.2 Angstrom==
-		+	<StructureSection load='6jnp' size='340' side='right'caption='[[6jnp]], [[Resolution\|resolution]] 2.26Å' scene=''>
-	~~Authors: Datta, S., Mondal, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6jnp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JNP FirstGlance]. <br>
-	~~Description:~~ Structure of ExoT-SpcS Complex from Pseudomonas aeruginosa in 2.2 Angstrom	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jnp OCA], [http://pdbe.org/6jnp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jnp RCSB], [http://www.ebi.ac.uk/pdbsum/6jnp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jnp ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Datta, S]]		[[Category: Datta, S]]
	[[Category: Mondal, A]]		[[Category: Mondal, A]]
		+	[[Category: Chaperone]]
		+	[[Category: Effector]]
		+	[[Category: Effector-toxin]]
		+	[[Category: Exot]]
		+	[[Category: Exotoxin]]
		+	[[Category: Pseudomona]]
		+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Spc]]
		+	[[Category: T3ss]]
		+	[[Category: Toxin]]

OCA: Protected "6jnp" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2019 04:52:22 GMT

Protected "6jnp" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:52, 27 March 2019

OCA: New page: '''Unreleased structure''' The entry 6jnp is ON HOLD Authors: Datta, S., Mondal, A. Description: Structure of ExoT-SpcS Complex from Pseudomonas aeruginosa in 2.2 Angstrom [[Category: ...

OCA — Wed, 27 Mar 2019 04:52:21 GMT

New page: '''Unreleased structure''' The entry 6jnp is ON HOLD Authors: Datta, S., Mondal, A. Description: Structure of ExoT-SpcS Complex from Pseudomonas aeruginosa in 2.2 Angstrom [[Category: ...

New page

'''Unreleased structure'''

The entry 6jnp is ON HOLD

Authors: Datta, S., Mondal, A.

Description: Structure of ExoT-SpcS Complex from Pseudomonas aeruginosa in 2.2 Angstrom
[[Category: Unreleased Structures]]
[[Category: Datta, S]]
[[Category: Mondal, A]]