OCA at 07:14, 11 March 2020

OCA — Wed, 11 Mar 2020 07:14:41 GMT

←Older revision		Revision as of 07:14, 11 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6jre is ~~ON HOLD until Paper~~ Publication	+	==Structure of N-terminal domain of Plasmodium vivax p43 (PfNTD) solved by Co-SAD phasing==
		+	<StructureSection load='6jre' size='340' side='right'caption='[[6jre]], [[Resolution\|resolution]] 2.59Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jre]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JRE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jre OCA], [http://pdbe.org/6jre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jre RCSB], [http://www.ebi.ac.uk/pdbsum/6jre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jre ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Scaffold modules known as aminoacyl-tRNA synthetase (aaRS)-interacting multifunctional proteins (AIMPs), such as AIMP1/p43, AIMP2/p38 and AIMP3/p18, are important in driving the assembly of multi-aaRS (MARS) complexes in eukaryotes. Often, AIMPs contain an N-terminal glutathione S-transferase (GST)-like domain and a C-terminal OB-fold tRNA-binding domain. Recently, the apicomplexan-specific Plasmodium falciparum p43 protein (Pfp43) has been annotated as an AIMP and its tRNA binding, tRNA import and membrane association have been characterized. The crystal structures of both the N- and C-terminal domains of the Plasmodium vivax p43 protein (Pvp43), which is an ortholog of Pfp43, have been resolved. Analyses reveal the overall oligomeric structure of Pvp43 and highlight several notable features that show Pvp43 to be a soluble, cytosolic protein. The dimeric assembly of the N-terminal GST-like domain of Pvp43 differs significantly from canonical GST dimers, and it is tied to the C-terminal tRNA-binding domain via a linker region. This work therefore establishes a framework for dissecting the additional roles of p43 orthologs in eukaryotic multi-protein MARS complexes.

-	~~Authors: Manickam, Y~~., ~~Harlos~~, K., Sharma, M~~., Gupta~~, S., ~~Sharma~~, A.	+	Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.,Gupta S, Chhibber-Goel J, Sharma M, Parvez S, Harlos K, Sharma A, Yogavel M Acta Crystallogr D Struct Biol. 2020 Feb 1;76(Pt 2):135-146. doi:, 10.1107/S2059798319016413. Epub 2020 Jan 30. PMID:32038044<ref>PMID:32038044</ref>

-	~~Description: Structure~~ of ~~N-terminal domain~~ of ~~Plasmodium vivax p43 (PfNTD) solved by Co-SAD phasing~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Manickam, Y]]~~	+	<div class="pdbe-citations 6jre" style="background-color:#fffaf0;"></div>
-	~~[[Category: Sharma, M]]~~	+	== References ==
-	[[Category: ~~Harlos, K~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gupta, S]]		[[Category: Gupta, S]]
		+	[[Category: Harlos, K]]
		+	[[Category: Manickam, Y]]
	[[Category: Sharma, A]]		[[Category: Sharma, A]]
		+	[[Category: Sharma, M]]
		+	[[Category: Aimp1]]
		+	[[Category: Gst-like domain]]
		+	[[Category: Ligase]]
		+	[[Category: Plasmodium]]

OCA at 04:42, 24 April 2019

OCA — Wed, 24 Apr 2019 04:42:26 GMT

←Older revision		Revision as of 04:42, 24 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jre is ON HOLD	+	The entry 6jre is ON HOLD until Paper Publication

	Authors: Manickam, Y., Harlos, K., Sharma, M., Gupta, S., Sharma, A.		Authors: Manickam, Y., Harlos, K., Sharma, M., Gupta, S., Sharma, A.

OCA: Protected "6jre" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2019 05:25:05 GMT

Protected "6jre" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 10 April 2019

OCA: New page: '''Unreleased structure''' The entry 6jre is ON HOLD Authors: Manickam, Y., Harlos, K., Sharma, M., Gupta, S., Sharma, A. Description: Structure of N-terminal domain of Plasmodium viva...

OCA — Wed, 10 Apr 2019 05:25:04 GMT

New page: '''Unreleased structure''' The entry 6jre is ON HOLD Authors: Manickam, Y., Harlos, K., Sharma, M., Gupta, S., Sharma, A. Description: Structure of N-terminal domain of Plasmodium viva...

New page

'''Unreleased structure'''

The entry 6jre is ON HOLD

Authors: Manickam, Y., Harlos, K., Sharma, M., Gupta, S., Sharma, A.

Description: Structure of N-terminal domain of Plasmodium vivax p43 (PfNTD) solved by Co-SAD phasing
[[Category: Unreleased Structures]]
[[Category: Manickam, Y]]
[[Category: Sharma, M]]
[[Category: Harlos, K]]
[[Category: Gupta, S]]
[[Category: Sharma, A]]

6jre - Revision history

OCA at 07:14, 11 March 2020

OCA at 04:42, 24 April 2019

OCA: Protected "6jre" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6jre is ON HOLD Authors: Manickam, Y., Harlos, K., Sharma, M., Gupta, S., Sharma, A. Description: Structure of N-terminal domain of Plasmodium viva...