6jrj - Revision history

OCA at 10:39, 27 March 2024

OCA — Wed, 27 Mar 2024 10:39:30 GMT

←Older revision		Revision as of 10:39, 27 March 2024
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	==The structure of co-crystals of 8r-B-EGFR T790M/C797S complex==		==The structure of co-crystals of 8r-B-EGFR T790M/C797S complex==
-	<StructureSection load='6jrj' size='340' side='right'caption='[[6jrj]]' scene=''>	+	<StructureSection load='6jrj' size='340' side='right'caption='[[6jrj]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JRJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6JRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JRJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jrj OCA], [~~http~~://pdbe.org/6jrj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jrj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jrj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jrj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.943Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6O:6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one'>C6O</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jrj OCA], [https://pdbe.org/6jrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jrj RCSB], [https://www.ebi.ac.uk/pdbsum/6jrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jrj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN] Defects in EGFR are associated with lung cancer (LNCR) [MIM:[https://omim.org/entry/211980 211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN] Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref> Isoform 2 may act as an antagonist of EGF action.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref>
		+
		+	==See Also==
		+	*[[Epidermal growth factor receptor 3D structures\|Epidermal growth factor receptor 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Yun CH]]		[[Category: Yun CH]]
	[[Category: Zhu SJ]]		[[Category: Zhu SJ]]

OCA at 06:50, 15 April 2020

OCA — Wed, 15 Apr 2020 06:50:23 GMT

←Older revision		Revision as of 06:50, 15 April 2020
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-	'''Unreleased structure'''

-	~~The entry 6jrj is ON HOLD~~	+	==The structure of co-crystals of 8r-B-EGFR T790M/C797S complex==
-		+	<StructureSection load='6jrj' size='340' side='right'caption='[[6jrj]]' scene=''>
-	~~Authors: Zhu, S.J., Yun, C.H.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JRJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JRJ FirstGlance]. <br>
-	~~Description:~~ The structure of co-crystals of 8r-B-EGFR T790M/C797S complex	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jrj OCA], [http://pdbe.org/6jrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jrj RCSB], [http://www.ebi.ac.uk/pdbsum/6jrj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jrj ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Yun~~, C.H~~]]	+	__TOC__
-	[[Category: Zhu~~, S.J~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Yun CH]]
		+	[[Category: Zhu SJ]]

OCA at 03:58, 17 April 2019

OCA — Wed, 17 Apr 2019 03:58:09 GMT

←Older revision		Revision as of 03:58, 17 April 2019
Line 5:		Line 5:
	Authors: Zhu, S.J., Yun, C.H.		Authors: Zhu, S.J., Yun, C.H.

-	Description: ~~the~~ structure of co-crystals of 8r-B-EGFR T790M/C797S complex	+	Description: The structure of co-crystals of 8r-B-EGFR T790M/C797S complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yun, C.H]]		[[Category: Yun, C.H]]
	[[Category: Zhu, S.J]]		[[Category: Zhu, S.J]]

OCA: Protected "6jrj" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2019 05:25:33 GMT

Protected "6jrj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 10 April 2019

OCA: New page: '''Unreleased structure''' The entry 6jrj is ON HOLD Authors: Zhu, S.J., Yun, C.H. Description: the structure of co-crystals of 8r-B-EGFR T790M/C797S complex [[Category: Unreleased Str...

OCA — Wed, 10 Apr 2019 05:25:32 GMT

New page: '''Unreleased structure''' The entry 6jrj is ON HOLD Authors: Zhu, S.J., Yun, C.H. Description: the structure of co-crystals of 8r-B-EGFR T790M/C797S complex [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 6jrj is ON HOLD

Authors: Zhu, S.J., Yun, C.H.

Description: the structure of co-crystals of 8r-B-EGFR T790M/C797S complex
[[Category: Unreleased Structures]]
[[Category: Yun, C.H]]
[[Category: Zhu, S.J]]