6juh - Revision history

OCA at 10:19, 22 November 2023

OCA — Wed, 22 Nov 2023 10:19:58 GMT

←Older revision		Revision as of 10:19, 22 November 2023
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	<StructureSection load='6juh' size='340' side='right'caption='[[6juh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6juh' size='340' side='right'caption='[[6juh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6juh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JUH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JUH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6juh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aliarcobacter_butzleri_RM4018 Aliarcobacter butzleri RM4018]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JUH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C9X:2-[phenyl-(phenylmethyl)amino]ethyl+(4~{R})-5-(5,5-dimethyl-2-oxidanylidene-1,3,2$l^{5}-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate'>C9X</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G3P:SN-GLYCEROL-3-PHOSPHATE'>G3P</scene>, <scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6juh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6juh OCA], [~~http~~://pdbe.org/6juh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6juh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6juh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6juh ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C9X:2-[phenyl-(phenylmethyl)amino]ethyl+(4~{R})-5-(5,5-dimethyl-2-oxidanylidene-1,3,2$l^{5}-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate'>C9X</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G3P:SN-GLYCEROL-3-PHOSPHATE'>G3P</scene>, <scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6juh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6juh OCA], [https://pdbe.org/6juh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6juh RCSB], [https://www.ebi.ac.uk/pdbsum/6juh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6juh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8EVM5_ALIB4 A8EVM5_ALIB4]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aliarcobacter butzleri RM4018]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Tang, L]]	+	[[Category: Tang L]]
-	[[Category: Xu, F]]	+	[[Category: Xu F]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Voltage-gated calcium channel block~~]]	+

OCA at 06:40, 6 November 2019

OCA — Wed, 06 Nov 2019 06:40:11 GMT

←Older revision		Revision as of 06:40, 6 November 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6juh is ~~ON HOLD until Paper~~ Publication	+	==structure of CavAb in complex with efonidipine==
		+	<StructureSection load='6juh' size='340' side='right'caption='[[6juh]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6juh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JUH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C9X:2-[phenyl-(phenylmethyl)amino]ethyl+(4~{R})-5-(5,5-dimethyl-2-oxidanylidene-1,3,2$l^{5}-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate'>C9X</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G3P:SN-GLYCEROL-3-PHOSPHATE'>G3P</scene>, <scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6juh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6juh OCA], [http://pdbe.org/6juh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6juh RCSB], [http://www.ebi.ac.uk/pdbsum/6juh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6juh ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Efonidipine is a dual L-/T- type calcium channel blocker with a slow onset of action and a long lasting effect that exibihits antihypertensive and nephroprotective effects. differs from most other DHPs which can induce reflex tachycardia. Efonidipine reduces blood pressure without decreasing cardiac output and exerts organ-protective effects on the heart and kidney. In order to investigate how efonidipine block voltage-gated Ca(2+) channel, we determined the crystal structure of CaVAb in complex with efonidipine at atomic resolution using x-ray crystallography. Our results reveal that efonidipine targets the central cavity of a model voltage-gated calcium channel underneath its selectivity filter and occlude the channel in an inactivated state. Binding of efonidipine does not break down the fourfold symmetry of the quaternary structure and its pore structure. Our work provides the structural basis for efonidipine block of a voltage-gated Ca(2+) channel at the molecular level.

-	~~Authors~~:	+	Structural basis for efonidipine block of a voltage-gated Ca(2+) channel.,Xu F, Xiong W, Huang Y, Shen J, Zhou D, Tang L Biochem Biophys Res Commun. 2019 Jun 4;513(3):631-634. doi:, 10.1016/j.bbrc.2019.03.176. Epub 2019 Apr 10. PMID:30981510<ref>PMID:30981510</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6juh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Tang, L]]
		+	[[Category: Xu, F]]
		+	[[Category: Membrane protein]]
		+	[[Category: Voltage-gated calcium channel block]]

OCA at 03:50, 12 June 2019

OCA — Wed, 12 Jun 2019 03:50:03 GMT

←Older revision		Revision as of 03:50, 12 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6juh is ON HOLD	+	The entry 6juh is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6juh" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2019 04:45:07 GMT

Protected "6juh" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:45, 24 April 2019

OCA: New page: '''Unreleased structure''' The entry 6juh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Apr 2019 04:45:05 GMT

New page: '''Unreleased structure''' The entry 6juh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6juh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]